Results 151 to 160 of about 12,356 (219)

Targeted Protein Degradation of NUDT5 Reveals an Unexpected Non-Enzymatic Role in 6-Thioguanine-Mediated Toxicity

Marques AMC, Bauer LG, Nguyen T, Orta AG, Venne J, Cheng L, Balikci E, Tivon B, London N, Kubicek S, Huber KVM.   +10 more
europepmc   +1 more source

MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation. [PDF]

Oncotarget, 2015
Grasso F, Ruggieri V, De Luca G, Leopardi P, Mancuso MT, Casorelli I, Pichierri P, Karran P, Bignami M.   +8 more
europepmc   +1 more source

BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine. [PDF]

Sci Rep, 2016
Gu Y, Helenius M, Väänänen K, Bulanova D, Saarela J, Sokolenko A, Martens J, Imyanitov E, Kuznetsov S.   +8 more
europepmc   +1 more source

Investigating the Therapeutic Activity of C₄N as a Targeted Drug Delivery System for Acetaminophen and Thioguanine through DFT Simulations. [PDF]

ACS Omega
Nazeer M, Yar M, Ayub K, Bayach I, Almutlaq N, Al Amer K.   +5 more
europepmc   +1 more source

Placing purines in precision medicine: Targeting a metabolic reliance in <i>KRAS</i>-mutant tumors. [PDF]

iScience
De Boni L, Claridge S, Nath S, Tofani K, Stein BD, Park E, Steiner S, Elemento O, Pauli C, Hopkins BD.   +9 more
europepmc   +1 more source

Decreased UV sensitivity, mismatch repair activity and abnormal cell cycle checkpoints in skin cancer cell lines derived from UVB-irradiated XPA-deficient mice [PDF]

イチカワ, ミノル, 市川, 稔
core  

Is thioguanine-associated sinusoidal obstruction syndrome avoidable? Lessons learned from 6-thioguanine treatment of inflammatory bowel disease and a mouse model [PDF]

, 2012
Duley, John A., Florin, Timothy H. J., Jharap, Bindia, Oancea, Iulia, van Asseldonk, Dirk P.   +4 more
core  

Development and Validation of a Sensitive Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method for the Simultaneous Quantification of Thiopurine Nucleotides in Human Red Blood Cells. [PDF]

Cureus
Singh M, Kaushal S, Gupta K, Sood A.
europepmc   +1 more source

Patenting Genes and Genetic Methods: What\u27s at Stake? [PDF]

, 2011
Kane, Eileen M.
core   +1 more source

EPI-SauriCas9-based mouse ovarian cancer models recapitulating pten deletion in patients. [PDF]

Commun Biol
Chen W, He P, Ding L, Lou W, Wang Y, Shi W, Fan Z, Sheng Y, Luo J, Tan Z, Wang Y, Di W, Ke X, Yu B.   +13 more
europepmc   +1 more source