Results 131 to 140 of about 7,966 (172)
Some of the next articles are maybe not open access.
Characterization of the DNA damage in 6-thioguanine-treated cells
Biochemical Pharmacology, 19906-Thioguanine (TG) incorporation into DNA has been associated with cytotoxicity and DNA damage in Chinese hamster ovary (CHO) and murine leukemia L1210 cells. According to alkaline elution analysis, single-strand breaks (SSB) occur in both cell types. DNA-protein and interstrand crosslinks are prominent features of TG effects in L1210, CEM, and HL-60 ...
B F, Pan, J A, Nelson
openaire +2 more sources
Hepatotoxicity Associated With 6-Thioguanine Therapy for Crohn's Disease
Journal of Clinical Gastroenterology, 20036-Thioguanine (6-TG) is a thiopurine analogue that is closely related to 6-mercaptopurine (6-MP) and azathioprine (AZA). These agents have potent cytotoxic and immunomodulatory effects and are useful in the treatment of a variety of conditions, including inflammatory bowel disease. Both 6-MP and AZA are widely used and are known to cause hepatotoxicity
Stephen J, Rulyak +2 more
openaire +2 more sources
On the Cellular Pharmacokinetics of 6-Thioguanine in Acute Myelogenous Leukemia
Leukemia & Lymphoma, 1991The pharmacokinetics of 6-thioguanine were studied in 10 patients with acute myelogenous leukemia treated with 25-100 mg/m(2) orally. The concentration of 6-thioguanine in plasma was determined with reversed phase high performance liquid chromatography (HPLC).
J, Liliemark +3 more
openaire +2 more sources
Mechanisms of resistance to 6-thioguanine in a murine pancreatic tumor
Cancer Chemotherapy and Pharmacology, 1992PANC02 is a unique experimental animal tumor that fails to respond significantly to any known clinically active antitumor agent. In this regard, the murine ductal adenocarcinoma resembles its human counterpart. To study the mechanism for its intrinsic resistance to 6-thioguanine (TG), we compared the metabolism of the drug in PANC02 and a reference, TG-
B F, Pan, T S, Priebe, J A, Nelson
openaire +2 more sources
Tautomers of 6-thioguanine: structures and properties
The Journal of Physical Chemistry, 1993The molecular geometries of four tautomers of 6-thioguanine (6TG) were studied using ab initio LCAO-MO method at the Hartree-Fock level. All considered species are minimum structures on the 3-21G ≡ 8 potential energy surface (PES) of 6TG as determined from harmonic vibrational frequencies calculations carried out at the same level.
openaire +1 more source
6-Thioguanine treatment of psoriasis: Experience in 81 patients
Journal of the American Academy of Dermatology, 1994Despite recent innovations a considerable number of patients with psoriasis cannot be successfully treated by current therapies.Our purpose was to summarize our 18-year experience with the antimetabolite 6-thioguanine in the management of patients with psoriasis.We retrospectively studied 81 patients who were treated with 6-thioguanine.
H S, Zackheim +3 more
openaire +2 more sources
Human lymphocytes resistant to 6-thioguanine increase with age
Mechanisms of Ageing and Development, 1982Using an autoradiographic technique we determined the number of circulating lymphocytes that were resistant to 6-thioguanine and which were presumably mutants at the hypoxanthine--guanine phosphoribosyl transferase locus. The number in normal individuals was found to increase exponentially with age.
A A, Morley, S, Cox, R, Holliday
openaire +2 more sources
Differentiation of neuroblastoma cells induced in culture by 6‐thioguanine
International Journal of Cancer, 1973AbstractIn addition to cell death, 6‐thioguanine (TG) and 6‐mercaptopurine induced neurite formation in mouse neuroblastoma cell culture, whereas 2‐aminopurine had no effect on growth or morphology. 6‐TG was much more potent in causing morphological differentiation than any other agents used in this study.
openaire +2 more sources
An hypothesis on the mechanism of action of 6-thioguanine
Biochemical Pharmacology, 1967R P, Miech +3 more
openaire +2 more sources
Crystal and molecular structure of 6-thioguanine
Journal of the American Chemical Society, 1970C E, Bugg, U, Thewalt
openaire +2 more sources