Results 121 to 130 of about 7,966 (172)

6-Thioguanine fromErwinia amylovora

Current Microbiology, 1986
Erwinia amylovora, the etiological agent of fireblight disease, was found to produce under aerobic conditions in axenic culture 2-amino-1,7-dihydro-6H-purine-6-thion (6-thioguanine, 6-TG), easily recognized by a UV absorbance at 340 nm (pH≤7) and readily distinguished from NADH by both its acid stability and the pH dependence of its UV spectrum.
Gottfried Feistner, Carle M. Staub
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Surface Layers of 6-Thioguanine on the Mercury Electrode

Journal of Colloid and Interface Science, 2002
The adsorption behavior of 6-thioguanine (6TG) on a hanging mercury drop electrode has been studied with ac and cyclic voltammetry in 0.1 M Na2SO4 and 0.01 M sodium acetate solutions at pH 4.3. Several condensed phases of chemically adsorbed 6TG as well as one phase of physically adsorbed 6TG have been characterized.
Zoraida González, Arias, Jesús Luis Muñiz, Alvarez, Juan Miguel López, Fonseca   +2 more
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A sensitive assay for 6-thioguanine-resistant lymphocytes

Mutation Research Letters, 1988
We have defined variants (V) resistant to 6-thioguanine (TG) by their ability to divide at least once during a 72-h incubation in a medium containing 0.2 mM TG. We blocked cytokinesis by adding cytochalasin B (CB) after 30 h in culture. The cells that had undergone nuclear division were identified by their content of 2 or more nuclei.
A, Norman, J C, Mitchell, K S, Iwamoto
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Mutagenic consequences of the incorporation of 6-thioguanine into DNA

Biochemical Pharmacology, 1997
6-Thioguanine (S6G) has been used in the treatment of acute leukemias because of its cytotoxic effect on proliferating leukemic cells. The cytotoxicity of S6G is thought to derive from its incorporation into DNA in place of guanine. The deoxyribonucleoside triphosphate of S6G, SdGTP, is a good substrate for bacterial and human DNA polymerases (Ling et ...
S, Uribe-Luna, J D, Quintana-Hau, R, Maldonado-Rodriguez, M, Espinosa-Lara, K L, Beattie, D, Farquhar, J A, Nelson   +6 more
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Radiosensitization of two murine fibrosarcomas with 6-thioguanine

International Journal of Radiation Oncology*Biology*Physics, 1990
In Vivo murine tumor experiments were carried out to determine whether 6-thioguanine (6-TG) could enhance the cytotoxic effects of radiation on tumors. The combined effects of single and fractionated x-irradiation were evaluated on the transplanted methylcholanthrene induced fibrosarcoma (Meth-A) in BALB/c mice, a moderately radioresponsive tumor and ...
J H, Kim, A A, Alfieri, S H, Kim, S S, Hong   +3 more
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Enhancement of 6-thioguanine cytotoxic activity with methotrexate

Biochemical and Biophysical Research Communications, 1982
Abstract Studies were completed to characterize the cytotoxic and biochemical interaction of methotrexate (MTX) and 6-thioguanine (6-TG). Pretreatment of L1210 leukemia cells for 3 hr with MTX substantially enhanced the cytotoxicity of 6-TG. The LD90 of 6-TG in cells pretreated with 1μM MTX was 0.9pM, compared to an LD90 of 800 pM when the two drugs ...
R D, Armstrong, R, Vera, P, Snyder, E, Cadman   +3 more
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Pharmacokinetics of 6-Thioguanine in Patients With Inflammatory Bowel Disease

Therapeutic Drug Monitoring, 2006
6-Thioguanine (6-TG) seems to be an attractive alternative in both AZA- and 6-MP-intolerant and -resistant IBD populations. However, little is known of 6-TG pharmacokinetics, metabolite levels, and their correlation with drug efficacy and toxicity in IBD patients.
Derijks, Luc J. J., Gilissen, Lennard P. L., Engels, Leopold G. J. B., Bos, Laurens P., Bus, Paul J., Lohman, Joseph J. H. M., van Deventer, Sander J. H., Hommes, Daniel W., Hooymans, Piet M.   +8 more
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6-THIOGUANINE BIOSYNTHESIS IN ERWINIA SPECIES

Acta Horticulturae, 2014
Erwinia amylovora produces a compound with an absorbance maximum at 340 nm that forms a yellow colored complex with copper. This compound was identified as 6-thioguanine, a guanine analogue that is used in chemotherapy and the treatment of inflammatory bowel disease.
A. Wensing, M. Gernold, S. Jock, W. Jelkmann, K. Geider, A. Beck, R. Jansen   +6 more
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Spectrofluorometric determination of thiopurines—I 6-Thioguanine

Talanta, 1976
6-Thioguanine is oxidized to the corresponding S-oxide by reaction with hydrogen peroxide in 50% acetic acid at 50 degrees for 5 min. The S-oxide is highly fluorescent and a rapid and sensitive fluorometric method of determination of thioguanine at the ng ml level in water and mug ml level in blood serum and urine has been developed on the basis of ...
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Hepatic Veno-Occlusive Disease Caused by 6-Thioguanine

Annals of Internal Medicine, 1982
Clinically reversible veno-occlusive disease of the liver developed in a 23-year-old man with acute lymphocytic leukemia after 10 months of maintenance therapy with 6-thioguanine. Serial liver biopsies showed the development and resolution of intense sinusoidal engorgement. Although this disease was clinically reversible, some subintimal fibrosis about
R A, Gill, G R, Onstad, J M, Cardamone, D C, Maneval, H W, Sumner   +4 more
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