Results 111 to 120 of about 7,966 (172)

Levels of 6-thioguanine nucleotides and clinical remission in inflammatory bowel disease - A systematic review and meta-analysis: PS083. [PDF]

Porto Biomed J, 2017
Estevinho MM, Afonso J, Rosa I, Lago P, Trindade E, Correia L, Dias CC, Magro F.   +7 more
europepmc   +1 more source

Targeted Protein Degradation of NUDT5 Reveals an Unexpected Non-Enzymatic Role in 6-Thioguanine-Mediated Toxicity

Marques AMC, Bauer LG, Nguyen T, Orta AG, Venne J, Cheng L, Balikci E, Tivon B, London N, Kubicek S, Huber KVM.   +10 more
europepmc   +1 more source

MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation. [PDF]

Oncotarget, 2015
Grasso F, Ruggieri V, De Luca G, Leopardi P, Mancuso MT, Casorelli I, Pichierri P, Karran P, Bignami M.   +8 more
europepmc   +1 more source

Impact of Obesity on Chemotherapy Pharmacokinetics, Toxicity, and Survival Outcomes in Pediatric Acute Lymphoblastic Leukemia. [PDF]

Cureus
Nair A, Graifman G, Tahir U, Modi R, Parekh R, Cp RV, Khanal A.   +6 more
europepmc   +1 more source

Investigating the Therapeutic Activity of C₄N as a Targeted Drug Delivery System for Acetaminophen and Thioguanine through DFT Simulations. [PDF]

ACS Omega
Nazeer M, Yar M, Ayub K, Bayach I, Almutlaq N, Al Amer K.   +5 more
europepmc   +1 more source

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6-Methylthioguanylic Acid, a Metabolite of 6-Thioguanine

Biochemical Pharmacology, 1971
Abstract Human epidermoid carcinoma (H. Ep. No. 2) cells, grown in culture in the presence of 6-thioguanine- 35 S or methionine[methyl- 14 C] plus unlabeled 6-thioguanine, contained a previously undescribed metabolite that was characterized by Chromatographic and electrophoretic migration and by chemical and enzymatic hydrolysis as 6 ...
L L Bennett, Paula W Allan, P W Allan
exaly   +3 more sources

TREATMENT OF PSORIASIS WITH 6‐THIOGUANINE

Australasian Journal of Dermatology, 1988
SummaryFifty‐four patients with Psoriasis were treated with the antimetabolite, 6‐thioguanine (TG). Three were early drop‐outs due to side effects. Of 48 evaluable patients with plaque‐type lesions, mostly extensive, 79% achieved over 75% improvement as an initial response, 8% had over 50% improvement and 13% had less than 50% improvement. 65% retained
H S, Zackheim, H I, Maibach
openaire   +2 more sources

Transglycosylation Reactions of 6-Thioguanine Acyclonucleosides

Nucleosides, Nucleotides and Nucleic Acids, 2000
9-(2-Acetoxyethoxy)methyl-N2-acetyl-6-thoguanine (2) undergoes two different transglycosylation reactions: i) the 79 isomerization, which gives the respective 7-regioisomer (3) as the major product, ii) the 9S6 glycosyl migration, which leads to a 9,S6-disubstituted product (4). S6-Methylation completely stopped the reversibility of transglycosylation.
A, Manikowski, J, Boryski
openaire   +2 more sources

6-Thioguanine Metabolism in Human Erythrocytes

1991
Thiopurines must undergo enzymatic conversion into a variety of nucleotide derivatives in order to display cytotoxic activity [1]; the major ones in human erythrocytes are the 6-thioguanine nucleotides [2]. These compounds derive from the immunosuppressive agent azathioprine as well as from the cytotoxic drugs 6-thioguanine and 6-mercaptopurine [3 ...
A. Lucano, C. Crifo, SALERNO, Costantino
openaire   +3 more sources