Results 111 to 120 of about 12,356 (219)

Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine. [PDF]

Ther Drug Monit, 2021
Bayoumy AB, Mulder CJJ, Loganayagam A, Sanderson JD, Anderson S, Boekema PJ, Derijks LJJ, Ansari AR.   +7 more
europepmc   +1 more source

Steps in immunosuppression for renal transplantation [PDF]

, 1983
The authors provide a historical survey of the immunosuppressive agents that have been used to prevent allograft rejection.
Hakala, TR, Rosenthal, JT, Starzl, TE
core  

No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML 10 and 12 trials [PDF]

, 2005
Fetal liver tyrosine kinase 3 (FLT3) internal tandem duplications (ITDs) are powerful adverse prognostic indicators for relapse in acute myelold leukemia (AML) but the most efficacious therapy for FLT3/ ITD+ patients is currently unknown.
Burnett, AK, Gale, RE, Hills, R, Kottaridis, PD, Linch, DC, Srirangan, S, Wheatley, K   +6 more
core  

Mutations in a Membrane Permease or hpt Lead to 6-Thioguanine Resistance in Staphylococcus aureus. [PDF]

Antimicrob Agents Chemother, 2021
Chin D, Goncheva MI, Flannagan RS, Heinrichs DE.   +3 more
europepmc   +1 more source

Guanine derivatives as promising candidates for the development of purine-based antimalarial drugs

Frontiers in Parasitology
IntroductionThe increasing resistance of Plasmodium falciparum to existing antimalarial drugs drives the urgent need for novel therapeutic strategies. The purine salvage pathway in P.
Worlanyo Tashie, Harry P. de Koning, Nancy O. Duah-Quashie, Nancy O. Duah-Quashie, Neils B. Quashie, Neils B. Quashie, Neils B. Quashie   +6 more
doaj   +1 more source

The Inhibitory Effects of 6-Thioguanine and 6-Mercaptopurine on the USP2a Target Fatty Acid Synthase in Human Submaxillary Carcinoma Cells. [PDF]

Front Oncol, 2021
Cheng CP, Liu ST, Chiu YL, Huang SM, Ho CL.   +4 more
europepmc   +1 more source

Thiopurine S -methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs [PDF]

, 2018
Objective: More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs.
Fried, M., Kullak-Ublick, G., Rammert, C., Rentsch, K., von Eckardstein, A., Wusk, Barbara   +5 more
core  

Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia. [PDF]

Leukemia, 2021
Stanulla M, Schaeffeler E, Möricke A, Buchmann S, Zimmermann M, Igel S, Schmiegelow K, Flotho C, Hartmann H, Illsinger S, Sauerbrey A, Junk SV, Schütte P, Hinze L, Lauten M, Modlich S, Kolb R, Rossig C, Schwabe G, Gnekow AK, Fleischhack G, Schlegel PG, Schünemann HJ, Kratz CP, Cario G, Schrappe M, Schwab M.   +26 more
europepmc   +1 more source

In vivo efficacy of chitosan/interleukin-12 in controlling lung metastasis in 4T1 breast cancer model [PDF]

, 2013
Cancer immunotherapy has emerged as a leading front in cancer treatment. In contrast to other treatment methods such as radiation and surgery, immunotherapy trains the patient\u27s body to recognize and eliminate tumors, thus preventing reoccurrence of ...
Vo, Jimmy
core   +1 more source

Ultrathin Fe and Ni-layer single hydroxides as efficient drug delivery agents: A first-principles study

Results in Physics
This study investigates the intermolecular interactions between 6-mercaptopurine (MP) and 6-thioguanine (TG) drugs with Fe- and Ni-layered single hydroxides (LSH) using DFT calculations. Hydrogenated Fe and Ni LSH show the best performance as drug agents
Hazem Abdelsalam, Mahmoud A.S. Sakr, Mohamed A. Saad, Nahed H. Teleb, Omar H. Abd-Elkader, Qinfang Zhang   +5 more
doaj   +1 more source