Results 1 to 10 of about 10,117 (217)

Comparison of the use of 6-thioguanine riboside versus 6-thioguanine as calibration standard to monitor 6-thioguanine nucleotides in red blood cells

Journal of Pharmaceutical and Biomedical Analysis Open, 2023
The analytical methods reported to evaluate 6-Thioguanine nucleotides (6-TGNs) level in red blood cells (RBC) are based on the conversion of 6-TGNs to 6-Thioguanine (6-TG) using 6-thioguanine as calibration standard.Using the LC-DAD method previously ...
Roselyne Boulieu, Antoine Tourlonias, Magali Larger   +2 more
doaj   +3 more sources

Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel. [PDF]

Clin Pharmacol Ther
The Clinical Pharmacogenetics Implementation Consortium (CPIC) TPMT/NUDT15 Pharmacogene Curation Expert Panel (PCEP) conducted a comprehensive review of clinical, laboratory, and computational evidence to determine the clinical function assignments for TPMT and NUDT15 star alleles.
Tibben BM, Maillard M, Pratt VM, Moyer AM, Figueroa DM, Whirl-Carrillo M, Gaedigk A, Stocco G, Schwab M, Caudle KE, Yang JJ.   +10 more
europepmc   +2 more sources

Biotransformation of 6‐thioguanine in inflammatory bowel disease patients: a comparison of oral and intravenous administration of 6‐thioguanine [PDF]

British Journal of Pharmacology, 2011
BACKGROUND AND PURPOSEAlthough 6‐mercaptopurine and azathioprine are effective treatments in inflammatory bowel disease (IBD), many patients discontinue treatment because of side effects. 6‐Thioguanine (6‐TG) may be an alternative rescue therapy in these intolerant patients but the pharmacokinetics of 6‐TG are not fully described. Here we have measured
Gj Peters
exaly   +5 more sources

Guanine derivatives as promising candidates for the development of purine-based antimalarial drugs [PDF]

Frontiers in Parasitology
IntroductionThe increasing resistance of Plasmodium falciparum to existing antimalarial drugs drives the urgent need for novel therapeutic strategies. The purine salvage pathway in P.
Worlanyo Tashie, Harry P. de Koning, Nancy O. Duah-Quashie, Nancy O. Duah-Quashie, Neils B. Quashie, Neils B. Quashie, Neils B. Quashie   +6 more
doaj   +2 more sources

Cơ chế hấp phụ và sự tăng cường hóa học phổ SERS của mercaptopurine và thioguanine trên bề mặt Au6 cluster

Tạp chí Khoa học Đại học Cần Thơ, 2022
Các phép tính DFT (lý thuyết hàm mật độ) được sử dụng để làm sáng tỏ bản chất của quá trình hấp phụ các phân tử thuốc mercaptopurine (MP) và thioguanine (TG) trên bề mặt vàng, sử dụng Au6 cluster làm mô hình phản ứng.
Nguyễn Thị Nhật Hằng, Nguyễn Thành Tiên, Dương Thị Huyền, Nguyễn Thanh Sĩ, Phạm Vũ Nhật   +4 more
doaj   +3 more sources

Use of laser-triggered gold nanoparticle-grafted dual light and temperature-responsive polymeric sensor for the recognition of thioguanine as anti-tumor agent [PDF]

Nanomedicine Journal, 2020
Objective(s): Today, there is an urgent need for improved sensor materials for drug sensing and effective monitoring and interventions in this area are highly required to struggle drug abuse. The present study aimed to synthesize a thioguanine-responsive
Kamyar Pourghazi, Majid Amoli Diva, Mahsa Shahmirzadi   +2 more
doaj   +1 more source

Increments in DNA-thioguanine level during thiopurine-enhanced maintenance therapy of acute lymphoblastic leukemia

Haematologica, 2021
Maintenance therapy containing methotrexate and 6-mercapto - purine is essential to cure acute lymphoblastic leukemia (ALL). Cytotoxicity is elicited by incorporation of thioguanine nucleotides into DNA (DNA-TG), and higher leukocyte DNA-TG is ...
Rikke Hebo Larsen, Cecilie Utke Rank, Kathrine Grell, Lisbeth Nørgaard Møller, Ulrik Malthe Overgaard, Peter Kampmann, Jacob Nersting, Matilda Degn, Stine Nygaard Nielsen, Helle Holst, Birgitte Klug Albertsen, Peder Skov Wehner, Michael Thude Callesen, Jukka Kanerva, Thomas Leth Frandsen, Bodil Als-Nielsen, Lisa Lyngsie Hjalgrim, Kjeld Schmiegelow   +17 more
doaj   +1 more source

Development of innovative methodology for determination of 6-thioguanine in whole blood erythrocytes by HPLC–PDA-based technique for medical diagnostics purposes

Scientific Reports, 2023
6-Thioguanine is an immunosuppressive drug, an analogue of guanine, applied to treat acute leukemia and inflammatory bowel disease. Excessive use of 6-thioguanine during clinical treatment may cause side effects.
Maciej Noga, Marcin Zakrzewski, Dorota Wianowska, Maciej Gnatowski, Łukasz Paprotny, Kamil Jurowski   +5 more
doaj   +1 more source

Cytotoxicity of Thiopurine Drugs in Patients with Inflammatory Bowel Disease

Toxics, 2022
The effectiveness of thiopurine drugs in inflammatory bowel disease (IBD) was confirmed more than a half-century ago. It was proven that these can be essential immunomodulatory medications.
Oliwia Zakerska-Banaszak, Liliana Łykowska-Szuber, Michał Walczak, Joanna Żuraszek, Aleksandra Zielińska, Marzena Skrzypczak-Zielińska   +5 more
doaj   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source