Results 1 to 10 of about 199 (69)
Tạp chí Khoa học Đại học Cần Thơ, 2022 Các phép tính DFT (lý thuyết hàm mật độ) được sử dụng để làm sáng tỏ bản chất của quá trình hấp phụ các phân tử thuốc mercaptopurine (MP) và thioguanine (TG) trên bề mặt vàng, sử dụng Au6 cluster làm mô hình phản ứng.
Nguyễn Thị Nhật Hằng +4 more
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Journal of Pharmaceutical and Biomedical Analysis Open, 2023 The analytical methods reported to evaluate 6-Thioguanine nucleotides (6-TGNs) level in red blood cells (RBC) are based on the conversion of 6-TGNs to 6-Thioguanine (6-TG) using 6-thioguanine as calibration standard.Using the LC-DAD method previously ...
Roselyne Boulieu +2 more
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Use of laser-triggered gold nanoparticle-grafted dual light and temperature-responsive polymeric sensor for the recognition of thioguanine as anti-tumor agent [PDF]
Nanomedicine Journal, 2020 Objective(s): Today, there is an urgent need for improved sensor materials for drug sensing and effective monitoring and interventions in this area are highly required to struggle drug abuse. The present study aimed to synthesize a thioguanine-responsive
Kamyar Pourghazi +2 more
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Scientific Reports, 2023 6-Thioguanine is an immunosuppressive drug, an analogue of guanine, applied to treat acute leukemia and inflammatory bowel disease. Excessive use of 6-thioguanine during clinical treatment may cause side effects.
Maciej Noga +5 more
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Haematologica, 2021 Maintenance therapy containing methotrexate and 6-mercapto - purine is essential to cure acute lymphoblastic leukemia (ALL). Cytotoxicity is elicited by incorporation of thioguanine nucleotides into DNA (DNA-TG), and higher leukocyte DNA-TG is ...
Rikke Hebo Larsen +17 more
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Au Nanoparticle Loaded with 6-Thioguanine Anticancer Drug as a New Strategy for Drug Delivery [PDF]
Journal of Nanostructures, 2018 In this study we suggested a new strategy for drug delivery of 6-thioguanine (6-TG) as a cancer drug by loading of this thiolic drug at a surface of Au nanoparticles. For this goal, we synthesized Au nanoparticle (Au/NPs) by reduction of tetrachloroauric
Hassan Karimi-Maleh +4 more
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Thioguanine Induces Apoptosis in Triple-Negative Breast Cancer by Regulating PI3K–AKT Pathway
Frontiers in Oncology, 2020 Triple-negative breast cancer (TNBC) is notoriously difficult to treat due to the lack of biological targets and poor sensitivity to conventional therapies.
Daoyu Zhang +9 more
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Cytotoxicity of Thiopurine Drugs in Patients with Inflammatory Bowel Disease
Toxics, 2022 The effectiveness of thiopurine drugs in inflammatory bowel disease (IBD) was confirmed more than a half-century ago. It was proven that these can be essential immunomodulatory medications.
Oliwia Zakerska-Banaszak +5 more
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Journal of Electrochemical Science and Engineering, 2021 A sensitive electrochemical sensor was developed using reduced graphene oxide RGO-Cu2O/Fe2O3 nanocomposite for 6-mercaptopurine detection based on a facile fabrication method.
Fatemeh Irannezhad +2 more
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Journal of Pharmaceutical Policy and Practice, 2020 Drug repositioning is the scientific strategy of investigating existing drugs for additional clinical indications. The advantages of drug repositioning are that it benefits patients and that it adds new indications to existing drugs for lower costs ...
A. B. Bayoumy +4 more
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