Frontiers in Pharmacology, 2022 Thiopurines, including thioguanine (TG), 6-mercaptopurine (6-MP), and azathioprine (AZA), are extensively used in clinical practice in children with acute lymphoblastic leukemia (ALL) and inflammatory bowel diseases.
Hong-Li Guo +11 more
doaj +1 more source
6-thioguanine treatment in inflammatory bowel disease: A critical appraisal by a European 6-TG working party [PDF]
, 2006 Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004,
A. Teml +52 more
core +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
In vitro drug resistance profiles of adult versus childhood acute lymphoblastic leukaemia [PDF]
, 2000 Background and Aims: Nodular regenerative hyperplasia (NRH) of the liver is associated with several diseases and drugs. Clinical symptoms of NRH may vary from absence of symptoms to full-blown (noncirrhotic) portal hypertension.
Huismans, D.R. (D.) +5 more
core +10 more sources
Thiopurine 6TG treatment increases tumor immunogenicity and response to immune checkpoint blockade
OncoImmunology, 2023 Immune-checkpoint inhibitors (ICI) are highly effective in reinvigorating T cells to attack cancer. Nevertheless, a large subset of patients fails to benefit from ICI, partly due to lack of the cancer neoepitopes necessary to trigger an immune response ...
Loulieta Nazerai +14 more
doaj +1 more source
Inflammation, DNA-centered radicals, and oxidative genotoxicity: The role of HOCl produced by myeloperoxidase in carcinogenesis [PDF]
, 2009 Myeloid cells (macrophages and neutrophils) infiltrate and synthesize myeloperoxidase (MPO) in sites of inflammation, producing gentotoxicity. In RAW 264.7 macrophages, bacterial lipopolysaccharide (LPS) induces superoxide radical anion, nuclear ...
Dario C. Ramirez +2 more
core +2 more sources
Nanomaterials, 2023 Many purine derivatives are active pharmaceutical ingredients of significant importance in the therapy of autoimmune diseases, cancers, and viral infections.
Piotr Szyk +6 more
doaj +1 more source
Something more is necessary: are genes and genetic diagnostic tests statutory subject matter for US patents? [PDF]
, 2011 In a recent decision (AMP v. USPTO) from the US District Court, patent claims directed at DNA sequences corresponding to human genes and to diagnostic tests based on such genes have been found to be invalid, primarily on the basis that the DNA molecules ...
Cockbain, Julian, Sterckx, Sigrid
core +2 more sources
Idiopathic noncirrhotic portal hypertension: current perspectives [PDF]
, 2016 The term idiopathic noncirrhotic portal hypertension (INCPH) has been recently proposed to replace terms, such as hepatoportal sclerosis, idiopathic portal hypertension, incomplete septal cirrhosis, and nodular regenerative hyperplasia, used to describe ...
D'AMATI, Giulia +5 more
core +1 more source
Signalling cell cycle arrest and cell death through the MMR System [PDF]
, 2006 Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role in cancer, has been linked to resistance to certain DNA damaging agents including clinically important cytotoxic chemotherapeutics.
Brown, R., O'Brien, V.
core +1 more source