Results 21 to 30 of about 10,117 (217)

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence

Nature Communications, 2021
Coagulase-negative staphylococci and Staphylococcus aureus colonize similar niches in mammals. Here, Chin et al. show that a coagulase-negative staphylococcus secretes 6-thioguanine, a purine analog that suppresses S.
Denny Chin, Mariya I. Goncheva, Ronald S. Flannagan, Shayna R. Deecker, Veronica Guariglia-Oropeza, Alexander W. Ensminger, David E. Heinrichs   +6 more
doaj   +1 more source

Research progress of NT5C2 in disease and treatment [PDF]

Jichu yixue yu linchuang, 2023
Cytosolic 5'-nucleotidase Ⅱ(cN-Ⅱ), the protein encoded by NT5C2, can catalyze the dephosphory-lation of nucleoside monophosphate and is mainly involved in the regulation of purine nucleotide pool in cells.
SHU Ling, HUO Bennian, SONG Lin
doaj   +1 more source

Thiopurine 6TG treatment increases tumor immunogenicity and response to immune checkpoint blockade

OncoImmunology, 2023
Immune-checkpoint inhibitors (ICI) are highly effective in reinvigorating T cells to attack cancer. Nevertheless, a large subset of patients fails to benefit from ICI, partly due to lack of the cancer neoepitopes necessary to trigger an immune response ...
Loulieta Nazerai, Shona Caroline Willis, Patricio Yankilevich, Luca Di Leo, Francesca Maria Bosisio, Alex Frias, Corine Bertolotto, Jacob Nersting, Maria Thastrup, Soren Buus, Allan Randrup Thomsen, Morten Nielsen, Kristoffer Staal Rohrberg, Kjeld Schmiegelow, Daniela De Zio   +14 more
doaj   +1 more source

Polymer-Based Nanoparticles as Drug Delivery Systems for Purines of Established Importance in Medicine

Nanomaterials, 2023
Many purine derivatives are active pharmaceutical ingredients of significant importance in the therapy of autoimmune diseases, cancers, and viral infections.
Piotr Szyk, Beata Czarczynska-Goslinska, Dariusz T. Mlynarczyk, Barbara Ślusarska, Tomasz Kocki, Marta Ziegler-Borowska, Tomasz Goslinski   +6 more
doaj   +1 more source

6-Thioguanine Inhibits Herpes Simplex Virus 1 Infection of Eyes

Microbiology Spectrum, 2021
Herpes simplex virus 1 (HSV-1) infects eye corneal tissues leading to herpetic stromal keratitis (HSK), which is one of the leading causes of blindness.
Deyan Chen, Ye Liu, Fang Zhang, Qiao You, Wenyuan Ma, Jing Wu, Zhiwei Wu   +6 more
doaj   +1 more source

Thioguanine toxicity [PDF]

, 2001
The toxic action of the anticancer drug thioguanine is believed to involve incorporation into DNA, methylation by S-adenosylmethionine followed by binding of the resulting S6-methylthioguanine residues by proteins of the post-replicative mismatch repair ...
Sullivan, Dianne Clare
core   +1 more source

Thioguanine is Effective as Maintenance Therapy for Inflammatory Bowel Disease: A Prospective Multicentre Registry Study [PDF]

, 2023
Background and Aims: Thioguanine is a well-tolerated and effective therapy for inflammatory bowel disease [IBD] patients. Prospective effectiveness data are needed to substantiate the role of thioguanine as a maintenance therapy for IBD.Methods: IBD ...
Hoentjen, Frank, Petra van Boeckel, Gerard Dijkstra, Frank Kubben, Van Boeckel, Petra, Frank Hoentjen, Chris J J Mulder, Dijkstra, Gerard, Paul Boekema, Ingrid Gisbertz, Simsek, Melek, Schepers, Femke, Fidder, Herma, Herma Fidder, Sigal Kaplan, Kubben, Frank, Marleen de Leest, Van Asseldonk, Dirk, Ana Petrak, Gisbertz, Ingrid, Maurice Russel, Adriaan A van Bodegraven, Femke Schepers, Russel, Maurice, Mulder, Chris J.J., Else van de Poel, Meijssen, Maarten, Maarten Meijssen, Dijkstra, Gerard; id_orcid, Petrak, Ana, De Boer, Nanne, Melek Simsek, Dirk van Asseldonk, Nanne de Boer, Van De Poel, Else, Kaplan, Sigal, Boekema, Paul, Bindia Jharap, Van Bodegraven, Adriaan A., De Leest, Marleen, Jharap, Bindia   +40 more
core   +3 more sources

Histological remission of autoimmune hepatitis after the addition of allopurinol and azathioprine dose reduction

Autopsy and Case Reports, 2017
The standard therapy for some autoimmune diseases consists of a combination of corticosteroids and thiopurines. In non-responders to thiopurine drugs, the measurement of the metabolites of azathioprine, 6-thioguanine, and 6-methylmercaptopurine, can be a
Ana Luiza Vilar Guedes, Adriana Ribas Andrade, Vinicius Santos Nunes, Fabiana Roberto Lima, Evandro Sobroza de Mello, Suzane Kioko Ono, Débora Raquel Benedita Terrabuio, Eduardo Luiz Rachid Cançado   +7 more
doaj   +1 more source

Development and validation of a novel HPLC-UV method for simultaneous determination of azathioprine metabolites in human red blood cells

Heliyon, 2023
A rapid, specific and accurate high-performance liquid chromatography with tunable ultraviolet detection method was developed to simultaneously determine azathioprine metabolites, 6-thioguanine nucleotides (6-TGN) and 6-methyl mercaptopurine riboside (6 ...
Hengyi Yu, Dongyan Li, Dong Xiang, Xiping Li, Lu Liu, Dong Liu, Xuepeng Gong   +6 more
doaj   +1 more source