Results 1 to 10 of about 12,356 (219)

6-Thioguanine Inhibits Herpes Simplex Virus 1 Infection of Eyes [PDF]

Microbiology Spectrum, 2021
Herpes simplex virus 1 (HSV-1) infects eye corneal tissues leading to herpetic stromal keratitis (HSK), which is one of the leading causes of blindness.
Deyan Chen, Ye Liu, Fang Zhang, Qiao You, Wenyuan Ma, Jing Wu, Zhiwei Wu   +6 more
doaj   +4 more sources

6-thioguanine inhibits EV71 replication by reducing BIRC3-mediated autophagy [PDF]

BMC Microbiology
Background Enterovirus 71 (EV71) is one of the major causative agents of hand, foot, and mouth disease (HFMD), and can cause severe cerebral complications and even fatality in children younger than 5 years old.
Qiao You, Jing Wu, Ruining Lyu, Yurong Cai, Na Jiang, Ye Liu, Fang Zhang, Yating He, Deyan Chen, Zhiwei Wu   +9 more
doaj   +4 more sources

Development of innovative methodology for determination of 6-thioguanine in whole blood erythrocytes by HPLC–PDA-based technique for medical diagnostics purposes [PDF]

Scientific Reports, 2023
6-Thioguanine is an immunosuppressive drug, an analogue of guanine, applied to treat acute leukemia and inflammatory bowel disease. Excessive use of 6-thioguanine during clinical treatment may cause side effects.
Maciej Noga, Marcin Zakrzewski, Dorota Wianowska, Maciej Gnatowski, Łukasz Paprotny, Kamil Jurowski   +5 more
doaj   +2 more sources

6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro [PDF]

iScience, 2021
Summary: The emergence of SARS-CoV-2 has led to a global health crisis that, in addition to vaccines and immunomodulatory therapies, calls for the identification of antiviral therapeutics.
Caleb D. Swaim, Varun Dwivedi, Yi-Chieh Perng, Xu Zhao, Larissa A. Canadeo, Houda H. Harastani, Tamarand L. Darling, Adrianus C.M. Boon, Deborah J. Lenschow, Viraj Kulkarni, Jon M. Huibregtse   +10 more
doaj   +2 more sources

Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol [PDF]

BMC Cancer, 2022
Background A critical challenge in current acute lymphoblastic leukemia (ALL) therapy is treatment intensification in order to reduce the relapse rate in the subset of patients at the highest risk of relapse.
Linea Natalie Toksvang, Bodil Als-Nielsen, Christopher Bacon, Ruta Bertasiute, Ximo Duarte, Gabriele Escherich, Elín Anna Helgadottir, Inga Rinvoll Johannsdottir, Ólafur G. Jónsson, Piotr Kozlowski, Cecilia Langenskjöld, Kristi Lepik, Riitta Niinimäki, Ulrik Malthe Overgaard, Mari Punab, Riikka Räty, Heidi Segers, Inge van der Sluis, Owen Patrick Smith, Marion Strullu, Goda Vaitkevičienė, Hilde Skuterud Wik, Mats Heyman, Kjeld Schmiegelow   +23 more
doaj   +2 more sources

Ocular pharmacological and biochemical profiles of 6-thioguanine: a drug repurposing study [PDF]

Frontiers in Pharmacology
Introduction:The purine analog 6-thioguanine (6TG), an old drug approved in the 60s to treat acute myeloid leukemia (AML), was tested in the diabetic retinopathy (DR) experimental in vivo setting along with a molecular modeling approach.Methods:A ...
Maria Consiglia Trotta, Carlo Gesualdo, Caterina Claudia Lepre, Marina Russo, Marina Russo, Franca Ferraraccio, Iacopo Panarese, Ernesto Marano, Paolo Grieco, Francesco Petrillo, Francesco Petrillo, Anca Hermenean, Francesca Simonelli, Michele D’Amico, Claudio Bucolo, Francesca Lazzara, Filomena De Nigris, Settimio Rossi, Chiara Bianca Maria Platania   +18 more
doaj   +2 more sources

Ultrafast Excited-State Decay Mechanisms of 6-Thioguanine Followed by Sub-20 fs UV Transient Absorption Spectroscopy [PDF]

Molecules, 2022
Understanding the primary steps following UV photoexcitation in sulphur-substituted DNA bases (thiobases) is fundamental for developing new phototherapeutic drugs.
Danielle C. Teles-Ferreira, Cristian Manzoni, Lara Martínez-Fernández, Giulio Cerullo, Ana Maria de Paula, Rocío Borrego-Varillas   +5 more
doaj   +2 more sources

Excited-State Dynamics of the Thiopurine Prodrug 6-Thioguanine: Can N9-Glycosylation Affect Its Phototoxic Activity? [PDF]

Molecules, 2017
6-Thioguanine, an immunosuppressant and anticancer prodrug, has been shown to induce DNA damage and cell death following exposure to UVA radiation. Its metabolite, 6-thioguanosine, plays a major role in the prodrug’s overall photoreactivity.
Brennan Ashwood, Steffen Jockusch, Carlos E. Crespo-Hernández   +2 more
doaj   +2 more sources

Interaction of 6-Thioguanine with Aluminum Metal–Organic Framework Assisted by Mechano-Chemistry, In Vitro Delayed Drug Release, and Time-Dependent Toxicity to Leukemia Cells [PDF]

Nanomaterials
6-thioguanine (6-TG) is an antimetabolite drug of purine structure, approved by the FDA for the treatment of acute myeloid lesukemia, and it is of interest in treating other diseases.
Sheriff Umar, Xavier Welch, Chihurumanya Obichere, Brandon Carter-Cooper, Alexander Samokhvalov   +4 more
doaj   +2 more sources

The mechanism of thioamide formation by the YcfA-YcfC system in 6-thioguanine biosynthesis [PDF]

Nature Communications
6-thioguanine (6-TG) is a therapeutic medication for childhood acute lymphoblastic leukemia (ALL) and a potent antimicrobial agent. Its biosynthesis relies on the YcfA-YcfC system, yet the formation of its critical thioamide moiety remains incompletely ...
Li Zhang, Chao Dou, Weizhu Yan, Pengpeng Chen, Xinyu Jia, Na Zhang, Dan Zhou, Zhaolin Long, Lu Zhang, Xiaofeng Zhu, Wei Cheng   +10 more
doaj   +2 more sources