Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update. [PDF]
Clin Pharmacol TherThiopurine methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) are key enzymes that catabolize thiopurines. Decreased or no‐function alleles in TPMT and NUDT15 are associated with reduced or no enzyme activity and predictive of pronounced adverse effects, including severe myelosuppression, that may occur among individuals treated with standard ...
Maillard M +18 more
europepmc +2 more sources
Case Report: Azathioprine: An Old and Wronged Immunosuppressant
Frontiers in Immunology, 2022 Mycophenolate rapidly substituted azathioprine (AZA) in transplant immunosuppression regimens since the 1990s, when early clinical trials indicated better outcomes, although opposite results were also observed. However, none of these trials used the well-
Pedro R. Chocair +10 more
doaj +1 more source
Bvr-1, a Restriction Locus of a Type C RNA Virus in the Feline Cellular Genome: Pleiotropic Restriction of Endogenous BALB Virus in Cat x Mouse Somatic Cell Hybrids [PDF]
, 1978 Bvr-1 is a dominant X-linked feline gene which restricts the replication of B-tropic murineleukemia virus (B-MuLV) in somatic cell hybrids between murine BALB/c-RAG cells and FL-74 feline cells.
O\u27Brien, Stephen J. +1 more
core +2 more sources
Acta Chimica Slovenica, 2020 Analysis of anticancer drugs is very important and necessary for the correct administration of them in the human body. Electrochemical behavior of 6-thioguanine (6-TG) has been studied using a carbon paste electrode modified by 1-ethyl-3 ...
Masoud Fouladgar
doaj +1 more source
Is porto sinusoidal vascular disease to be actively searched in patients with portal vein thrombosis? [PDF]
, 2019 Porto sinusoidal vascular liver disease (PSVD) and portal vein thrombosis (PVT) are distinct vascular liver diseases characterized, respectively, by an intrahepatic and a prehepatic obstacle to the flow in the liver portal system. PVT may also occur as a
D'Amati, G. +4 more
core +1 more source
Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes [PDF]
, 2014 Aim: We investigated candidate genes associated with thiopurine metabolism and clinical response in childhood acute lymphoblastic leukemia. Materials & methods: We performed genome-wide SNP association studies of 6-thioguanine and 6-mercaptopurine ...
Batzler, A. +10 more
core +1 more source
Contemporary Oncology, 2018 Sinusoidal obstruction syndrome (SOS), also termed veno-occlusive disease (VOD) of the liver, is a well-known complication of haematopoietic stem cell transplantation (HSCT) both in children and adults.
Dorota Pawlik-Gwozdecka +3 more
doaj +1 more source
Role of Oxidative Stress Mediated by Glutathione-S-transferase in Thiopurines' Toxic Effects [PDF]
, 2015 Azathioprine (AZA), 6-mercaptopurine (6-MP), and 6-thioguanine (6-TG) are antimetabolite drugs, widely used as immunosuppressants and anticancer agents.
De Iudicibus, Sara +9 more
core +1 more source
Traditional Chinese medicine combination therapy for patients with steroid-dependent ulcerative colitis: study protocol for a randomized controlled trial [PDF]
, 2017 SPIRIT 2013 Checklist: recommended items to address in a clinical trial protocol and related documents.
Hong Shen +6 more
core +3 more sources
Anti-angiogenic activity of the purine analog 6-thioguanine [PDF]
Leukemia, 2002 The antimetabolite 6-thioguanine (6-TG) is utilized in the management of acute myelogenous leukemia (AML). Angiogenesis is a possible therapeutic target in hematologic tumors. Thus, we addressed the possibility that 6-TG may also act as an anti-angiogenic molecule.
PRESTA, Marco +3 more
openaire +3 more sources