Results 51 to 60 of about 12,356 (219)

Use of Allopurinol with Low-Dose 6-Mercaptopurine in Inflammatory Bowel Disease to Achieve Optimal Active Metabolite Levels: A Review of Four Cases and the Literature

Canadian Journal of Gastroenterology, 2008
BACKGROUND: At least one-third of patients with inflammatory bowel disease do not respond or are intolerant to therapy with 6-mercaptopurine (6-MP). A subgroup fails to attain optimal levels of 6-thioguanine nucleotide (6-TGN) and instead shunts to 6 ...
Todd N Witte, Allen L Ginsberg
doaj   +1 more source

6‐Thioguanine in children with acute lymphoblastic leukaemia: influence of food on parent drug pharmacokinetics and 6‐thioguanine nucleotide concentrations [PDF]

British Journal of Clinical Pharmacology, 2001
Aims  Since relatively little is known about the pharmacokinetics of 6‐thioguanine (6TG) in children receiving 6‐thioguanine for maintenance therapy of acute lymphoblastic leukaemia (ALL), we studied plasma drug concentrations under standardized conditions and investigated the effect of food on parent drug pharmacokinetics and the accumulation of the ...
D L, Lancaster, N, Patel, L, Lennard, J S, Lilleyman   +3 more
openaire   +2 more sources

Peliosis hepatis induced by 6-thioguanine administration. [PDF]

Gut, 1988
A patient with acute myeloblastic leukaemia developed jaundice revealing peliosis hepatis after receiving 6-thioguanine for two months. Peliosis hepatis was severe and was associated with mild lesions of centrilobular veins. Withdrawal of 6-thioguanine was followed by a progressive improvement of liver dysfunction. This report shows that 6-thioguanine,
D, Larrey, E, Fréneaux, A, Berson, G, Babany, C, Degott, D, Valla, D, Pessayre, J P, Benhamou   +7 more
openaire   +2 more sources

Thiopurine 6TG treatment increases tumor immunogenicity and response to immune checkpoint blockade

OncoImmunology, 2023
Immune-checkpoint inhibitors (ICI) are highly effective in reinvigorating T cells to attack cancer. Nevertheless, a large subset of patients fails to benefit from ICI, partly due to lack of the cancer neoepitopes necessary to trigger an immune response ...
Loulieta Nazerai, Shona Caroline Willis, Patricio Yankilevich, Luca Di Leo, Francesca Maria Bosisio, Alex Frias, Corine Bertolotto, Jacob Nersting, Maria Thastrup, Soren Buus, Allan Randrup Thomsen, Morten Nielsen, Kristoffer Staal Rohrberg, Kjeld Schmiegelow, Daniela De Zio   +14 more
doaj   +1 more source

Secondary treatment of polycythemia rubra vera with 6-thioguanine [PDF]

Cancer, 1982
6-thioguanine, an antimetabolite not potentiated by allopurinol, has been used in the treatment of 29 patients with polycythemia vera. All but two of the patients had been treated previously by venesection and/or radioactive phosphorus (32p) and/or alkylating agents.
D W, Milligan, S L, Thein, B E, Roberts
openaire   +2 more sources

The drug-survival of low-dose thioguanine in patients with inflammatory bowel disease: a retrospective observational study

Therapeutic Advances in Gastroenterology
Background: Thiopurines are commonly used to treat inflammatory bowel disease but withdrawal due to side effects are common. Thioguanine has been suggested to be better tolerated than conventional thiopurines.
Helena Gensmyr-Singer, Mårten Werner, Pontus Karling   +2 more
doaj   +1 more source

MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia

Haematologica, 2018
Survival of children with relapsed acute lymphoblastic leukemia is poor, and understanding mechanisms underlying resistance is essential to developing new therapy.
Nikki A. Evensen, P. Pallavi Madhusoodhan, Julia Meyer, Jason Saliba, Ashfiyah Chowdhury, David J. Araten, Jacob Nersting, Teena Bhatla, Tiffaney L. Vincent, David Teachey, Stephen P. Hunger, Jun Yang, Kjeld Schmiegelow, William L. Carroll   +13 more
doaj   +1 more source

In vitro Anti-inflammatory Evaluation of 6-Thioguanine and 6-Hydroxy-2-Mercaptopurine as A Potential Treatment for Rheumatoid Arthritis

Indonesian Biomedical Journal, 2021
BACKGROUND: Eventhough 6-Mercaptopurine act as a major drug for rheumatoid arthritis (RA) treatment, however, its toxicity become a limitation. Therefore, this current study investigated whether 6-hydroxy-2-mercaptopurine (6H2MP) and 6-thioguanine (6TG ...
Nurul Syuhada Nordin, Yong Yoke Keong, Siti Farah Md Tohid, Zetty Nadia Md Zain, Muhammad Nazrul Hakim   +4 more
doaj   +1 more source

Azathioprine-Induced Peripheral T Cell Apoptosis And Drug Response In Patients With Crohn’s Disease [PDF]

, 2011
Background and Aim: the long time interval for a trial of thioupurine therapy and the potential side effects in spite of the proven efficacy, do not encourage their use as early therapeutic option in Crohn’s Disease (CD).
Cossu, Andrea
core  

A phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA defective tumours: a study protocol [PDF]

, 2014
BACKGROUND: BRCA1 and BRCA2 genes are critical in homologous recombination DNA repair and have been implicated in familial breast and ovarian cancer tumorigenesis. Tumour cells with these mutations demonstrate increased sensitivity to cisplatin and poly (
, Boyle, Lucy, Collins, Linda, Dutton, Susan J, Gourley, Charlie, Hall, Marcia, Kopijasz, Sylwia, Montes, Ana, Nicum, Shibani, Poole, Christopher, Roberts, Corran, Schuh, Anna   +11 more
core   +2 more sources