Results 31 to 40 of about 12,356 (219)

Something more is necessary: are genes and genetic diagnostic tests statutory subject matter for US patents? [PDF]

, 2011
In a recent decision (AMP v. USPTO) from the US District Court, patent claims directed at DNA sequences corresponding to human genes and to diagnostic tests based on such genes have been found to be invalid, primarily on the basis that the DNA molecules ...
Cockbain, Julian, Sterckx, Sigrid
core   +2 more sources

Biotransformation of 6‐thioguanine in inflammatory bowel disease patients: a comparison of oral and intravenous administration of 6‐thioguanine [PDF]

British Journal of Pharmacology, 2011
BACKGROUND AND PURPOSEAlthough 6‐mercaptopurine and azathioprine are effective treatments in inflammatory bowel disease (IBD), many patients discontinue treatment because of side effects. 6‐Thioguanine (6‐TG) may be an alternative rescue therapy in these intolerant patients but the pharmacokinetics of 6‐TG are not fully described. Here we have measured
Jharap, B., de Boer, N.K., Vos, R.M., Smid, K., Zwiers, A., Peters, G.J., Mulder, C.J.J., Wilhelm, A.J., van Bodegraven, A.A.   +8 more
openaire   +4 more sources

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. [PDF]

, 2015
Leydig cells are crucial to the production of testosterone in males. It is unknown if the cancer chemotherapeutic drug, 6-mercaptopurine (6 MP), produces Leydig cell failure among adult survivors of childhood acute lymphoblastic leukemia. Moreover, it is
Bao, Ju, Chemaitilly, Wassim, Frase, Sharon, Green, Daniel M, Janke, Laura, Lynch, John, Morgan, Jessica A, Opferman, Joseph T, Panetta, John C, Schuetz, John D, Wang, Yao, Zheng, Jie   +11 more
core   +1 more source

Histological remission of autoimmune hepatitis after the addition of allopurinol and azathioprine dose reduction

Autopsy and Case Reports, 2017
The standard therapy for some autoimmune diseases consists of a combination of corticosteroids and thiopurines. In non-responders to thiopurine drugs, the measurement of the metabolites of azathioprine, 6-thioguanine, and 6-methylmercaptopurine, can be a
Ana Luiza Vilar Guedes, Adriana Ribas Andrade, Vinicius Santos Nunes, Fabiana Roberto Lima, Evandro Sobroza de Mello, Suzane Kioko Ono, Débora Raquel Benedita Terrabuio, Eduardo Luiz Rachid Cançado   +7 more
doaj   +1 more source

Adverse Reactions to Drugs of Special Interest in a Pediatric Oncohematology Service

Frontiers in Pharmacology, 2021
Introduction: Drugs used in oncological diseases are frequently related to adverse drug reactions (ADR). Few studies have analyzed the toxicity of cancer treatments in children in real practice.Methods: An observational, longitudinal and prospective ...
Kristopher Amaro-Hosey, Kristopher Amaro-Hosey, Immaculada Danés, Immaculada Danés, Immaculada Danés, Lourdes Vendrell, Lourdes Vendrell, Lourdes Vendrell, Laura Alonso, Laura Alonso, Berta Renedo, Luis Gros, Luis Gros, Xavier Vidal, Xavier Vidal, Xavier Vidal, Gloria Cereza, Gloria Cereza, Gloria Cereza, Antònia Agustí, Antònia Agustí, Antònia Agustí   +21 more
doaj   +1 more source

Signalling cell cycle arrest and cell death through the MMR System [PDF]

, 2006
Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role in cancer, has been linked to resistance to certain DNA damaging agents including clinically important cytotoxic chemotherapeutics.
Brown, R., O'Brien, V.
core   +1 more source

The possibility of using shogaol for treatment of ulcerative colitis [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): This study aimed to investigate the effect of Shogaol on dextran sodium sulfate (DSS)- induced ulcerative colitis (UC) in mice compared to an immune-suppressant chemotherapeutic medicine, known as 6-thioguanine (6-TG). Materials and Methods:
Snur Hassan, Ali Hassan
doaj   +1 more source

Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus [PDF]

, 2016
Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects.
Attarbaschi, Andishe, Barzilai, Shlomit, Escherich, Gabriele, Frandsen, Thomas Leth, Halsey, Christina, Hough, Rachael, Jeha, Sima, Kato, Motohiro, Liang, Der-Cherng, Mikkelsen, Torben Stamm, Moricke, Anja, Niinimaki, Riitta, Piette, Caroline, Putti, Maria Caterina, Raetz, Elizabeth, Schmiegelow, Kjeld, Silverman, Lewis B., Skinner, Roderick, Tuckuviene, Ruta, van der Sluis, Inge, Zapotocka, Ester   +20 more
core   +2 more sources

Electrochemical oxidation of 6-thioguanine

Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1986
Abstract The electrochemical exidation pathway of 6-thioguanine was investigated by cyclic voltammetry, constant-potential electrolysis, coulometry, UV/VIS spectroscopy and mass spectrometry. Experimental evidence indicates that the oxidation pathway depends on potential.
Department of Chemistry, University of Florida Gainesville, FL 32611 U.S.A. ( host institution ), Kraske, P.J. ( author ), Brajter-Toth, ( author )   +2 more
openaire   +2 more sources

Utility of Maternal 6-Thioguanine Nucleotide Levels in Predicting Neonatal Pancytopenia

American Journal of Perinatology Reports, 2013
An infant with pancytopenia was born to a mother who used the common immunosuppressant azathioprine (AZA). Maternal and neonatal blood levels of 6-thioguanine nucleotides (6TGN; metabolite of AZA) were 1890 and 1480 pmol/8 × 108 red blood cells ...
Hidehiko Maruyama, Katsuhiko Tada, Takuzo Fujiwara, Kosuke Ota, Misao Kageyama   +4 more
doaj   +1 more source