Results 31 to 40 of about 7,966 (172)
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Autopsy and Case Reports, 2017 The standard therapy for some autoimmune diseases consists of a combination of corticosteroids and thiopurines. In non-responders to thiopurine drugs, the measurement of the metabolites of azathioprine, 6-thioguanine, and 6-methylmercaptopurine, can be a
Ana Luiza Vilar Guedes +7 more
doaj +1 more source
Nature Communications, 2021 Coagulase-negative staphylococci and Staphylococcus aureus colonize similar niches in mammals. Here, Chin et al. show that a coagulase-negative staphylococcus secretes 6-thioguanine, a purine analog that suppresses S.
Denny Chin +6 more
doaj +1 more source
Adverse Reactions to Drugs of Special Interest in a Pediatric Oncohematology Service
Frontiers in Pharmacology, 2021 Introduction: Drugs used in oncological diseases are frequently related to adverse drug reactions (ADR). Few studies have analyzed the toxicity of cancer treatments in children in real practice.Methods: An observational, longitudinal and prospective ...
Kristopher Amaro-Hosey +21 more
doaj +1 more source
Effect of 6-thioguanine on the stability of duplex DNA [PDF]
Nucleic Acids Research, 2005 Abstract The incorporation of 6-thioguanine (S6G) into DNA is a prerequisite for its cytotoxic action, but duplex structure is not significantly perturbed by the presence of the lesion [J. Bohon and C. R. de los Santos (2003) Nucleic Acids Res ., 31, 1331–1338]. It is therefore possible that the mechanism of cytotoxicity relies on a loss
Bohon, Jen, de los Santos, Carlos R.
openaire +2 more sources
The possibility of using shogaol for treatment of ulcerative colitis [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): This study aimed to investigate the effect of Shogaol on dextran sodium sulfate (DSS)- induced ulcerative colitis (UC) in mice compared to an immune-suppressant chemotherapeutic medicine, known as 6-thioguanine (6-TG). Materials and Methods:
Snur Hassan, Ali Hassan
doaj +1 more source
Utility of Maternal 6-Thioguanine Nucleotide Levels in Predicting Neonatal Pancytopenia
American Journal of Perinatology Reports, 2013 An infant with pancytopenia was born to a mother who used the common immunosuppressant azathioprine (AZA). Maternal and neonatal blood levels of 6-thioguanine nucleotides (6TGN; metabolite of AZA) were 1890 and 1480 pmol/8 × 108 red blood cells ...
Hidehiko Maruyama +4 more
doaj +1 more source
Acta Chimica Slovenica, 2020 Analysis of anticancer drugs is very important and necessary for the correct administration of them in the human body. Electrochemical behavior of 6-thioguanine (6-TG) has been studied using a carbon paste electrode modified by 1-ethyl-3 ...
Masoud Fouladgar
doaj +1 more source
Case Report: Azathioprine: An Old and Wronged Immunosuppressant
Frontiers in Immunology, 2022 Mycophenolate rapidly substituted azathioprine (AZA) in transplant immunosuppression regimens since the 1990s, when early clinical trials indicated better outcomes, although opposite results were also observed. However, none of these trials used the well-
Pedro R. Chocair +10 more
doaj +1 more source
Electrochemical oxidation of 6-thioguanine
Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1986 Abstract The electrochemical exidation pathway of 6-thioguanine was investigated by cyclic voltammetry, constant-potential electrolysis, coulometry, UV/VIS spectroscopy and mass spectrometry. Experimental evidence indicates that the oxidation pathway depends on potential.
Department of Chemistry, University of Florida Gainesville, FL 32611 U.S.A. ( host institution ) +2 more
openaire +2 more sources