Results 31 to 40 of about 10,117 (217)

Thioguanine treatment in psoriasis

Acta Dermato-Venereologica, 1987
The efficacy of thioguanine in the treatment of severe cases of psoriasis is demonstrated. This treatment is valuable in selected cases of severe psoriasis in whom other treatment is ineffective or impossible due to side effects. The effect of thioguanine on psoriasis lesions appears to run parallel with depression of the bone marrow.
L, Molin, K, Thomsen
openaire   +2 more sources

TPMT Genetic Variability and Its Association with Hematotoxicity in Indonesian Children with Acute Lymphoblastic Leukemia in Maintenance Therapy

Pharmacogenomics and Personalized Medicine, 2021
Dewi Selvina Rosdiana,1 Rianto Setiabudy,1 Rizka Andalusia,2,3 Djajadiman Gatot,4 Melva Louisa,1 Saptawati Bardosono,5 Instiaty Instiaty1 1Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia ...
Rosdiana DS, Setiabudy R, Andalusia R, Gatot D, Louisa M, Bardosono S, Instiaty I   +6 more
doaj  

A Nucleotide Analog Prevents Colitis-Associated Cancer via Beta-Catenin Independently of Inflammation and AutophagySummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine treatments are associated with a reduction in dysplasia and CAC in inflammatory bowel disease (IBD).
Yong Hua Sheng, Rabina Giri, Julie Davies, Veronika Schreiber, Saleh Alabbas, Ramya Movva, Yaowu He, Andy Wu, John Hooper, Brett McWhinney, Iulia Oancea, Gregor Kijanka, Sumaira Hasnain, Andrew J. Lucke, David P. Fairlie, Michael A. McGuckin, Timothy H. Florin, Jakob Begun   +17 more
doaj   +1 more source

Thioguanine therapy in inflammatory bowel diseases. A practical guide

, 2020
Thiopurine-derivates azathioprine and mercaptopurine are frequently used to maintain remission in inflammatory bowel diseases (IBD). Despite their efficacy, more than 50% of patients discontinue therapy, mainly due to the development of adverse events ...
Crouwel, Femke, Mulder, Chris J.J., Simsek, Melek, de Boer, Nanne K., Buiter, Hans J.C.   +4 more
core   +1 more source

Excited State Dynamics of 6-Thioguanine [PDF]

The Journal of Physical Chemistry A, 2017
Here we present the excited state dynamics of jet-cooled 6-thioguanine (6-TG), using resonance-enhanced multiphoton ionization (REMPI), IR-UV double resonance spectroscopy, and pump-probe spectroscopy in the nanosecond and picosecond time domains. We report data on two thiol tautomers, which appear to have different excited state dynamics.
Siouri, Faady M, Boldissar, Samuel, Berenbeim, Jacob A, de Vries, Mattanjah S   +3 more
openaire   +4 more sources

6-Thioguanine

, 2017
Inelastic Neutron Scattering spectrum of 6-Thioguanine, C₅H₅N₅S, measured on the TOSCA ...
J. Tomkinson, ISIS Facility
core   +1 more source

MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia

Haematologica, 2018
Survival of children with relapsed acute lymphoblastic leukemia is poor, and understanding mechanisms underlying resistance is essential to developing new therapy.
Nikki A. Evensen, P. Pallavi Madhusoodhan, Julia Meyer, Jason Saliba, Ashfiyah Chowdhury, David J. Araten, Jacob Nersting, Teena Bhatla, Tiffaney L. Vincent, David Teachey, Stephen P. Hunger, Jun Yang, Kjeld Schmiegelow, William L. Carroll   +13 more
doaj   +1 more source

The structure of thioguanine scaffold.

, 2019
The structure of thioguanine scaffold.
Ezatul Ezleen Kamarulzaman (6260978), Nornisah Mohamed (1375221), Noorsaadah Abd Rahman (550281), Maywan Hariono (6260969), Rohana Yusof (401395), Ros Fatihah Roslim (6260972), Sy Bing Choi (4408978), Habibah A. Wahab (1425556), Mei Lan Tan (678491), Shatrah Othman (6260981), Mohamed Sufian Nawi (6260975), Rozana Othman (677989)   +11 more
core   +1 more source

Sinusoidal obstruction syndrome in a paediatric patient with acute lymphoblastic leukaemia after completion of reinduction therapy according to ALL Intercontinental Berlin-Frankfurt-Münster 2009

Contemporary Oncology, 2018
Sinusoidal obstruction syndrome (SOS), also termed veno-occlusive disease (VOD) of the liver, is a well-known complication of haematopoietic stem cell transplantation (HSCT) both in children and adults.
Dorota Pawlik-Gwozdecka, Ninela Irga-Jaworska, Marek Tomaszewski, Elżbieta Adamkiewicz-Drożyńska   +3 more
doaj   +1 more source

Case Report: Azathioprine: An Old and Wronged Immunosuppressant

Frontiers in Immunology, 2022
Mycophenolate rapidly substituted azathioprine (AZA) in transplant immunosuppression regimens since the 1990s, when early clinical trials indicated better outcomes, although opposite results were also observed. However, none of these trials used the well-
Pedro R. Chocair, Precil Diego Miranda de Menezes Neves, Sara Mohrbacher, Maurilio Pacheco Neto, Victor A. H. Sato, Érico S. Oliveira, Leonardo V. Barbosa, Alessandra M. Bales, Fagner Pereira da Silva, Américo L. Cuvello-Neto, John A. Duley   +10 more
doaj   +1 more source