Results 51 to 60 of about 10,117 (217)
Treatment of Autoimmune Hepatitis
The Korean Journal of Gastroenterology, 2023 Autoimmune hepatitis (AIH) is a chronic liver disease, characterized by elevated levels of transaminases, immunoglobulin G, and positive autoantibodies. The disease course is dynamic and presents heterogeneous disease manifestations at diagnosis.
Ja Kyung Kim
doaj +1 more source
Assay of 6‐thioguanine in human plasma. [PDF]
British Journal of Clinical Pharmacology, 1980 1. A fluorimetric method has been developed for measuring therapeutic concentrations of 6‐thioguanine in human plasma. The drug was measured as an oxidized derivative, guanine 6‐sulphonate. 2. 6‐thioguanine was extracted from plasma by a novel procedure which isolated the drug from an interfering plasma components. This method involved the formation of
T, Dooley, J L, Maddocks
openaire +2 more sources
Thiopurine therapies: Problems, complexities and progress with monitoring thioguanine nucleotides
, 2005 Metabolism of thiopurine drugs-azathioprine, 6-mercaptopurine, and 6-thioguanine-has provided a powerful pharmacogenetic model incorporating polymorphism of the enzyme thiopurine methyltransferase (TPMT) and the primary active metabolite, thioguanine ...
Duley, J. A. +3 more
core +1 more source
Results in ChemistryIn this study, the absorption and interaction effects of the anticancer drug 6-Thioguanine in various orientations on the β-cyclodextrin nanocarrier were theoretically investigated and optimized using Gaussian 09 software. Quantum mechanical calculations,
Sepideh Shokri Shams +2 more
doaj +1 more source
Indonesian Biomedical Journal, 2021 BACKGROUND: Eventhough 6-Mercaptopurine act as a major drug for rheumatoid arthritis (RA) treatment, however, its toxicity become a limitation. Therefore, this current study investigated whether 6-hydroxy-2-mercaptopurine (6H2MP) and 6-thioguanine (6TG ...
Nurul Syuhada Nordin +4 more
doaj +1 more source
Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia
Journal of Medical Imaging and Radiation Oncology, EarlyView.ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes +2 more
wiley +1 more source
6‐Thioguanine — efficacy and safety in chronic active Crohn's disease
, 2003 Background: Azathioprine and mercaptopurine are commonly used in chronic active Crohn's disease. They share the disadvantage of a delayed onset of action and potentially serious side-effects, and are metabolized to thioguanine nucleotides which are ...
Schwab, M. +10 more
core +1 more source
, 2018 Disposable graphite pencil electrodes were used in this study for the electrochemical determination of 6-thioguanine using its interaction with a single-stranded Oligo (A)25 composed of 25 adenine (A) bases or double-stranded Oligo (A)25-Oligo (T)25, a ...
Unal D.N., Erdem A., Eksin E.
core +2 more sources
The Impact of Common Medications on Male Fertility: An Updated Systematic Review
Andrology, EarlyView.ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli +7 more
wiley +1 more source
Thioguanine in Inflammatory Bowel Disease:Finding hidden treasures in old drugs [PDF]
This thesis was dedicated to provide a comprehensive insight into the safe and efficacious utilization of thioguanine as an immunosuppressive treatment for inflammatory bowel diseases (IBD) encompassing Crohn’s disease and ulcerative colitis ...
Simsek, Melek
core +1 more source