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6-thioguanine inhibits EV71 replication by reducing BIRC3-mediated autophagy
Background Enterovirus 71 (EV71) is one of the major causative agents of hand, foot, and mouth disease (HFMD), and can cause severe cerebral complications and even fatality in children younger than 5 years old.
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Deoxythioguanosine and thioguanine
Clinical Pharmacology & Therapeutics, 1973Incorporation of 6‐thioguanine (TG) and β‐2'‐deoxythioguanosine (β‐TGdR) into the DNA and RNA of human bone marrow and tumors were measured. The ratio of incorporation into DNA vs that into RNA was taken as an indication of the extent to which β‐TGdR was a direct precursor for DNA synthesis without conversion to TG.
G A, LePage, J A, Gottlieb
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Fluorometric Assay of Thioguanine
Journal of Pharmaceutical Sciences, 1975A spectrophotofluorometric method is described for the assay of thioguanine. The assay involves the oxidation of thioguanine with potassium permanganate to a fluorescent product. The method is suitable for routine quality control in laboratory preparations of thioguanine.
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