Results 71 to 80 of about 10,117 (217)

Critical assessment of thioguanine treatment for inflammatory bowel diseases: Is it time to rehabilitate this treatment?

, 2017
OBJECTIVE: The potential therapeutic effect of thioguanine in the management of inflammatory bowel disease (IBD) is hindered due to association with vascular hepatotoxicity.
Khan, Sohil A., Oancea, Iulia, Iulia Oancea, Florin, Timothy H. J., Khan, Sohil, Ramya Movva, Florin, Timothy HJ, Haywood, Alison, Timothy HJ Florin, Khan, Sohil A, Sohil A Khan, Alison Haywood, Movva, Ramya   +12 more
core   +1 more source

Exploring the Anticancer Potential of Schiff Base Complexes: A Mini‐Review

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Schiff base metal complexes as promising anticancer agents: highlighting DNA interactions, cytotoxicity, molecular targets, and mechanisms of cancer cell death. Schiff bases are well known for their ability to form stable coordination compounds with several transition metals, making them valuable for medicinal chemistry purposes.
Atif Ahmad, Anam, Marcos V. Palmeira‐Mello, Sabir Khan, José Clayston Melo Pereira   +4 more
wiley   +1 more source

Improving the outcomes of elderly patients with acute myeloid leukemia in a Brazilian University Hospital

Clinics, 2011
OBJECTIVE: To evaluate the outcomes of acute myeloid leukemia patients who were older than 60 years of age at the time of diagnosis following the implementation of a treatment algorithm based on age, performance status, and cytogenetic results.
Alex Freire Sandes, Juliana Correa da Costa Ribeiro, Rodrigo S. Barroso, Maria R.R. Silva, Maria L.L.F. Chauffaille   +4 more
doaj   +1 more source

Effects of Short‐Term Energy Limitation at Different Levels With Normal Protein Intake on Hepatic Lipid Metabolism and the Gut Microbiota in Overweight/Obese Mice

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
These findings demonstrate that with adequate protein intake, graded short‐term EL (20%–40%) effectively improves hepatic lipid metabolism and modulates gut microbiota composition in overweight/obese mice, although these regulatory effects exhibit pronounced sex‐specific differences.
Ying Tian, Yao Tang, Mingxia Gu, Jiawei Gong, Ying Zhou, Yuqing He, Keyu Huang   +6 more
wiley   +1 more source

6-Thioguanine in the Treatment of Psoriasis: A Case Report and Literature Review

, 2002
Background: 6-Thioguanine is a purine analog primarily indicated for acute myelogenous leukemia. Its use in psoriasis was first investigated in the 1950s and current interest in serious treatments for psoriasis, such as cyclosporine, has renewed interest
Daniel W. Sherer, Mark G. Lebwohl
core   +1 more source

DNA-thioguanine nucleotide as a treatment marker in acute lymphoblastic leukemia patients with NUDT15 variant genotypes.

PLoS ONE, 2021
BackgroundLarge inter-individual variations in drug metabolism pose a challenge in determining 6-mercaptopurine (6MP) doses. As the last product of 6MP metabolism, DNA-thioguanine nucleotide (DNA-TGN) could reflect the efficacy of 6MP, especially in ...
Hee Young Ju, Ji Won Lee, Hee Won Cho, Ju Kyung Hyun, Youngeun Ma, Eun Sang Yi, Keon Hee Yoo, Ki Woong Sung, Rihwa Choi, Hong Hoe Koo, Soo-Youn Lee   +10 more
doaj   +1 more source

Review Article: The Impact of the Gut Microbiome on Ulcerative Colitis Pharmacotherapy

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 6, Page 729-747, September 2026.
The gut microbiome modulates ulcerative colitis pharmacotherapy through microbial drug metabolism, immune regulation and altered drug bioavailability. Microbial composition influences response to aminosalicylates, corticosteroids, immunomodulators, biologics and small molecules, while microbiome‐targeted therapies show emerging promise.
Kate Collins, Srinivas Kamath, Rachel H. Davis, Samuel P. Costello, Robert V. Bryant, Alice S. Day, Paul Joyce   +6 more
wiley   +1 more source

New Nanomedicine Approaches Using Gold-thioguanine Nanoconjugates as Metallo-Ligands

, 2011
Gold-thioguanine nanoconjugates (AuNP-TG) of size 3-4 nm were synthesized and the ratio between gold and 6-thioguanine (TG) was estimated as ~1:1.5 using a cyanide digestion method and confirmed by flame atomic absorption spectroscopic analysis.
Zambre, Ajit, Chanda, Nripen, Nripen Chanda, Ajit Zambre, Kattesh Katti, Sleightholm, Lee, Afrasiabi Navan, Zahra, Katti, Kattesh V., Kannan, Raghuraman Sayee, Raghuraman Kannan, Zahra Afrasiabi, Lee Sleightholm   +11 more
core   +1 more source

Exposure to Thioguanine During 117 Pregnancies in Women With Inflammatory Bowel Disease. [PDF]

, 2023
BACKGROUND: Safety of thioguanine in pregnant patients with inflammatory bowel disease [IBD] is sparsely recorded. This study was aimed to document the safety of thioguanine during pregnancy and birth.
Horjus, C.S., Asseldonk, D.P. van, Boer, Marrit K. de, Gilissen, L.P., Simsek, M., Schaik, F.D. van, Bodegraven, A.A. van, Seinen, M.L., Kuijvenhoven, J.Ph, Voorn, M.M.P.J.A. van der, Visschedijk, M.C., Hoentjen, F., Boer, N.K. de, Creemers, R.H., Lutgens, M.W., Buiter, H.J.C., Dop, W.A. van, Bartelink, M.E.L., Tack, G.J., Ahmad, I., Wormmeester, L., Andel, E.M. van, Boeckel, P.G. van, Wonders, J., Boekema, P.J., Weusthuis, A.L.M., Crouwel, F., Mulder, C.J., Kerkhof, M. van de, Maljaars, J.W.J., Jharap, B., Russel, M.G.   +31 more
core  

Perforating dermatosis in a patient receiving azathioprine

Indian Journal of Dermatology, 2013
Azathioprine (AZA) is an imidazole derivative of mercaptopurine. It antagonizes purine metabolism, and it may inhibit synthesis of DNA, RNA, and proteins.
Emiliano Grillo, Sergio Vano-Galván, Carmen Moreno, Pedro Jaén   +3 more
doaj   +1 more source