Results 81 to 90 of about 10,117 (217)

Optimizing safety and efficacy of asparaginase and blinatumomab therapy in frontline acute lymphoblastic leukemia regimens in diverse health care settings—international expert consensus

Cancer, Volume 132, Issue 16, 15 August 2026.
ABSTRACT Frontline blinatumomab combined with chemotherapy has resulted in improved outcomes in both pediatric and adult patients with acute lymphoblastic leukemia and is considered the new cornerstone of acute lymphoblastic leukemia treatment. The role of asparaginase in this new landscape of acute lymphoblastic leukemia treatment was extensively ...
Daniel J. DeAngelo, Anna Avagyan, Jeanine Alfaro, Valentino Conter, Maria L. de Martino Lee, Łukasz Hutnik, Miriam Hwang, Hiroto Inaba, Atsushi Manabe, Jae H. Park, Rob Pieters, Carmelo Rizzari, Vaskar Saha, David T. Teachey, Inge M. van der Sluis, Scott C. Howard   +15 more
wiley   +1 more source

Acute and Chronic Leukemia in Sub‐Saharan Africa: A Systematic Review

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background The four primary subgroups of leukemia include chronic myeloid leukemia (CML), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic lymphocytic leukemia (CLL). Very little is known about the regional variation of leukemia and subtypes in sub‐Saharan Africa (SSA).
Allwell A. Ayirebi, Stephen Twumasi, Linda K. Olaga, Benedict Sackey, Daniel N. M. Antonio, Richard O. Ansah, Eugene A. Ansah, John A. Sah, Enoch O. Anto, Yvonne Anang‐Quartey, Antoinette Koomson, Angela Opoku, Godfred A. Donkor, Paulina Duah, Ama G. Boadu, Samuel Essien‐Baidoo, Wina I. O. Boadu, Lilian A. Boateng   +17 more
wiley   +1 more source

Limited relevance and progression of histological alterations in the liver during thioguanine therapy in inflammatory bowel disease patients

, 2019
Background: Thioguanine is associated with liver toxicity, especially nodular regenerative hyperplasia (NRH). We assessed if liver histology alters during long-term maintenance treatment with thioguanine in patients with inflammatory bowel disease (IBD).
Mulder, Chris J. J., van Nieuwkerk, Carin M., van Bodegraven, Adriaan A., Westerveld, Dik B., Simsek, Melek, van Asseldonk, Dirk P., Verheij, Joanne, den Hartog, Gijsbert, Becx, Marco C., Russel, Maurice G., Lissenberg-Witte, Birgit I., Bloemena, Elisabeth, de Boer, Nanne K. H., Jharap, Bindia   +13 more
core   +3 more sources

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

9239 POSTER Rapid Method to Measure Thioguanine Incorporation Into DNA

, 2011
Background: The thiopurine drugs, 6-mercaptopurine, azathioprine, and thioguanine, are used in the treatment of acute lymphoblastic leukaemia (ALL). During treatment the thioguanine nucleotides formed are incorporated into the DNA, causing apoptosis due ...
Coulthard, S,, Peterson, Curt,, Vikingsson, Svante,, S. Vikingsson, S. Coulthard, M. Josefsson, B. Carlsson, Josefsson, Martin,, Almer, Sven,, Carlsson, Björn,, S. Aimer, C. Peterson   +11 more
core   +1 more source

Selumetinib as a Target Therapy in Progressive Paediatric Low‐Grade Gliomas—Case Series (pLGG)

Journal of Paediatrics and Child Health, Volume 62, Issue 8, Page 1499-1508, August 2026.
ABSTRACT Background Optic pathway gliomas (OPGs) occur in 15%–20% of children with neurofibromatosis type 1 (NF1). While smaller gliomas may be only monitored, the current standard of care for symptomatic ones relies on chemotherapy, most commonly carboplatin and vincristine.
Laura Trapani, Giulia Gortani, Andrea Magnolato, Flora Maria Murru, Elisabetta Cattaruzzi, Laura Diplotti, Paola Michieletto, Silvia Giganti, Davide Zanon, Alessandra Maestro, Valentina Kiren, Egidio Barbi, Irene Bruno   +12 more
wiley   +1 more source

6-thioguanine biosynthesis in Erwinia species

, 2014
Erwinia amylovora produces a compound with an absorbance maximum at 340 nm that forms a yellow colored complex with copper. This compound was identified as 6-thioguanine, a guanine analogue that is used in chemotherapy and the treatment of inflammatory ...
Wensing, Annette, Gernold, M., Geider, Klaus, Beck, A., Jansen, R., Jelkmann, Wilhelm, Jock, S.   +6 more
core  

Promising treatment of autoimmune hepatitis with 6-thioguanine after adverse events on azathioprine

, 2005
The use of corticosteroids in autoimmune hepatitis is an established therapy. To avoid the possible serious side effects of corticosteroids, immunosuppression with azathioprine is often warranted.
Pages, M. Nieves Aparicio, Mulder, Chris J.J., Van Nieuwkerk, Carin M.J., Derijks, Luc J.J., De Boer, Sybrand Y., De Boer, Nanne K.H.   +5 more
core   +1 more source

Stability Study and Beyond-Use Date Determination of a Compounded Thioguanine Suspension

, 2020
Extemporaneous compounding is routine in pharmacies, and it is essential that the compounding pharmacists and practitioners have information on the formula, compounding directions and stability of the preparations they compound.
Gilda, Sagar
core  

Thioguanine used in maintenance therapy of chronic myeloid leukaemia causes non-cirrhotic portal hypertension. Results from MRC CML. II. Trial comparing busulphan with busulphan and thioguanine.

, 1991
Portal hypertension with varices developed in 18/675 patients with chronic myeloid leukaemia (CML) in a randomized trial comparing busulphan with busulphan and thioguanine.
Fooks, J, Gray, Richard, Gray, R, Shepherd, PC, Allan, NC   +4 more
core   +1 more source