Results 81 to 90 of about 268 (134)

TREATMENT OF PSORIASIS WITH 6‐THIOGUANINE

Australasian Journal of Dermatology, 1988
SummaryFifty‐four patients with Psoriasis were treated with the antimetabolite, 6‐thioguanine (TG). Three were early drop‐outs due to side effects. Of 48 evaluable patients with plaque‐type lesions, mostly extensive, 79% achieved over 75% improvement as an initial response, 8% had over 50% improvement and 13% had less than 50% improvement. 65% retained
H S, Zackheim, H I, Maibach
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The actions of thioguanine in Bacillus cereus

Biochemical Pharmacology, 1965
Abstract The effects of the guanine analog, 6-thioguanine, have been evaluated in exponentially growing cultures of Bacillus cereus . The drug produced growth inhibition instantly, the duration but not the degree of which was related to the inhibitor concentration.
H G, Mandel, R G, Latimer, M, Riis
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Encapsulation of thioguanine in liposomes

International Journal of Pharmaceutics, 1995
Abstract Thioguanine, a chemotherapeutic drug employed in the treatment of leukemia, was encapsulated in three kinds of liposomes: extrusion, ethanol injection and dehydration-rehydration vesicles. The degree of entrapment was examined at three different concentrations, 1, 0.1 and 0.01 mM, and three pH values, 4.7, 7.4 and 9.2.
Mercè Foradada, Joan Estelrich
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Thioguanine, Mercaptopurine: Their Analogs and Nucleosides as Antimetabolites

Current Pharmaceutical Design, 2003
6-Mercaptopurine (6MP) and 6-thioguanine (6TG) are analogs of the natural purines: hypoxanthine and guanine. Both mercaptopurine and thioguanine are substrates for hypoxanthine-guanine phosphoribosyltransferase and are converted into the ribonucleotides 6-thioguanosine monophosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) respectively.
Galal H Elgemeie
exaly   +3 more sources

Stability of compounded thioguanine oral suspensions

American Journal of Health-System Pharmacy, 2011
PURPOSE. Updated information on the stability of compounded thioguanine oral suspensions prepared with currently available ingredients, as well as results of testing to determine if the addition of an antioxidant could extend shelf life by inhibiting formation of guanine, are presented. METHODS.
Hamidreza Montazeri, Aliabadi, Marcel, Romanick, Vishwa, Somayaji, Parvin, Mahdipoor, Afsaneh, Lavasanifar   +4 more
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6-Thioguanine Metabolism in Human Erythrocytes

1991
Thiopurines must undergo enzymatic conversion into a variety of nucleotide derivatives in order to display cytotoxic activity [1]; the major ones in human erythrocytes are the 6-thioguanine nucleotides [2]. These compounds derive from the immunosuppressive agent azathioprine as well as from the cytotoxic drugs 6-thioguanine and 6-mercaptopurine [3 ...
A. Lucano, C. Crifo, SALERNO, Costantino
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Transglycosylation Reactions of 6-Thioguanine Acyclonucleosides

Nucleosides, Nucleotides and Nucleic Acids, 2000
9-(2-Acetoxyethoxy)methyl-N2-acetyl-6-thoguanine (2) undergoes two different transglycosylation reactions: i) the 79 isomerization, which gives the respective 7-regioisomer (3) as the major product, ii) the 9S6 glycosyl migration, which leads to a 9,S6-disubstituted product (4). S6-Methylation completely stopped the reversibility of transglycosylation.
A, Manikowski, J, Boryski
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The Inhibition of Hemagglutinin Formation in Mice by Thioguanine

The Journal of Immunology, 1962
Summary Thioguanine at a dose of 2.5 mg/kg was shown to be an effective inhibitor of the primary hemagglutinin response in both mice and rabbits. Similarly, 6-MP at a level of 15 mg/kg, prevented the formation of sheep cell hemagglutinins in rabbits. In mice, evidence of suppression was obtained with doses of 2.5 mg/kg begun on the first
A W, FRISCH, G H, DAVIES, V, MILSTEIN
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Correction: Dosage of Thioguanine

Annals of Internal Medicine, 1975
Excerpt To the editor: In the letter "Hyperphosphatemia and Hypocalcemia in Myeloproliferative Disorder" (Ann Intern Med81:119-120, 1974), the dose of thioguanine was published as 25 mg/kg body wei...
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Efficiency of isolation of revertible 6-thioguanine resistant clones is dependant on the concentration of thioguanine used for selection

Carcinogenesis, 1981
The availability of a number of well characterised mammalian cell mutants which revert at measurable frequencies when exposed to specific chemical mutagens would considerably aid analysis of mechanisms of mutagenesis in mammalian cells, might ultimately provide the mammalian cell equivalent of the "Ames' tester strains and could aid the understanding ...
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