Results 91 to 100 of about 10,117 (217)

Thioguanine for the treatment of atopic dermatitis

, 2019
Azathioprine (AZA) is commonly used in the treatment of atopic dermatitis (AD), but high discontinuation rates due to side effects and ineffectiveness are reported.
Garritsen, F.M., de Bruin-Weller, M.S.
core  

Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine and 6-thioguanine, in human red blood cells

, 1983
An assay for 6-thioguanine (6-TG) nucleotide, a major metabolite of the cytotoxic drugs azathioprine, 6-mercaptopurine and 6-thioguanine in human red blood cells (RBCs) has been developed.
J L Maddocks, L Lennard
core   +1 more source

Effect of 6-Thioguanine and Methyl-6-Thioguanine on stability of DNA duplexes [PDF]

, 2002
6-Thioguanine (65G) has been used for the past thirty years as an anti-cancer agent in maintenance chemotherapy for childhood acute lymphoblastic leukemia as well as acute myeloid leukemia.
Rodwell, Mabaera
core   +1 more source

Effect of Shogaol on the Expression of Intestinal Stem Cell Markers in Experimentally Induced Colitis in BALB/c Mice

Analytical Cellular Pathology, 2019
Aim. This study is aimed at investigating the effect of Shogaol, a phenolic constituent of ginger, on dextran sodium sulfate- (DSS-) induced ulcerative colitis (UC) in mice in comparison with 6-thioguanine (6-TG), an immune-suppressant chemotherapeutic ...
Snur M. A. Hassan, Ali Hussein Hassan
doaj   +1 more source

A New Electrochemical Sensor for Direct Detection of Purine Antimetabolites and DNA Degradation

Journal of Analytical Methods in Chemistry, 2019
The development of a reliable electrochemical sensor using a hybrid nanocomposite consisting of ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate) functionalized graphene oxide (GrO-IL) and gold nanoparticles (AuNPs) stabilized by chitosan ...
Liliya K. Shpigun, Elena Yu. Andryukhina
doaj   +1 more source

Gold–Thiopurine and Thioguanine Platforms for Chemotherapy and Photodynamic Therapy

ChemistryEurope
A modular family of gold(I) complexes containing the thiopurine bases 6‐mercaptopurine (6‐MP) or 6‐thioguanine (6‐TG), phosphine or N‐heterocyclic carbene ligands, and appended chromophores (dansyl or nitrobenzoxadiazole, NBD) has been synthesized to ...
Laura Agulló, Juan Carlos Pérez‐Sánchez, María Gil‐Moles, M. Concepción Gimeno   +3 more
doaj   +1 more source

Pharmacological evaluation of drug therapies in Aicardi-Goutières syndrome: insights from patient-derived neural stem cells

Frontiers in Pharmacology
Aicardi-Goutières syndrome (AGS) is a rare genetic disorder classified among type I interferonopathies. Current pharmacological management of AGS is symptomatic and supportive, with recent clinical applications of JAK inhibitors (JAKi) and antiretroviral
Stefania Braidotti, Rosalba Monica Ferraro, Rosalba Monica Ferraro, Raffaella Franca, Elena Genova, Francesco Giambuzzi, Andrea Mancini, Valentina Marinozzi, Letizia Pugnetti, Giulia Zudeh, Alessandra Tesser, Alberto Tommasini, Alberto Tommasini, Giuliana Decorti, Giuliana Decorti, Silvia Clara Giliani, Silvia Clara Giliani, Gabriele Stocco, Gabriele Stocco   +18 more
doaj   +1 more source

A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity

, 2013
Objective\ud \ud - The anti-leukemic drugs, azathioprine and 6-mercaptopurine (6MP), are important in the treatment of inflammatory bowel disease but an alternative faster-acting, less-allergenic thiopurine, 6-thioguanine (6TG), can cause hepatic veno ...
Png, C.W., McGuckin, M.A., Levesque, J.-P., Duley, J.A., Florin, T.H.J., Lourie, R., McWhinney, B.C., Das, I., Oancea, I., Winkler, I.G., Jinnah, H.A., Eri, R., Subramaniam, V.N.   +12 more
core   +1 more source

Differentiating agents + low-dose chemotherapy in the management of old/poor prognosis patients with acute myeloid leukemia or myelodysplastic syndrome

Haematologica, 2004
13-cis retinoic acid + (OH)2 vitamin D3 + low-dose 6-thioguanine and cytarabine were tested in 26 patients with acute myeloid leukemia (AML) and in 4 patients with myelodysplastic syndrome (MDS) (median age 72.5), ineligible for standard chemotherapy ...
D Ferrero, E Campa, C Dellacasa, S Campana, C Foli, M Boccadoro   +5 more
doaj  

Hepatotoxicity during 6-thioguanine treatment in inflammatory bowel disease and childhood acute lymphoblastic leukaemia: A systematic review.

PLoS ONE, 2019
BackgroundThe recently established association between higher levels of DNA-incorporated thioguanine nucleotides and lower relapse risk in childhood acute lymphoblastic leukaemia (ALL) calls for reassessment of prolonged 6-thioguanine (6TG) treatment ...
Linea Natalie Toksvang, Magnus Strøh Schmidt, Sofie Arup, Rikke Hebo Larsen, Thomas Leth Frandsen, Kjeld Schmiegelow, Cecilie Utke Rank   +6 more
doaj   +1 more source