Results 111 to 120 of about 10,117 (217)

Thioguanine Anhydrous [PDF]

, 2020
openaire   +1 more source

Placing purines in precision medicine: Targeting a metabolic reliance in <i>KRAS</i>-mutant tumors. [PDF]

iScience
De Boni L, Claridge S, Nath S, Tofani K, Stein BD, Park E, Steiner S, Elemento O, Pauli C, Hopkins BD.   +9 more
europepmc   +1 more source

Targeted Protein Degradation of NUDT5 Dissociates Catalytic Inhibition from Protein Loss in 6-Thioguanine Response. [PDF]

Nat Commun
Marques AMC, Bauer LG, Nguyen TA, Orta AG, Venne JL, Cheng C, Balıkçı E, Liu Y, Tivon B, Kroupova A, Ciulli A, London N, Kubicek S, Huber KVM.   +13 more
europepmc   +1 more source

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update. [PDF]

Clin Pharmacol Ther
Maillard M, Schwab M, Whirl-Carrillo M, Moyer AM, Suarez-Kurtz G, Pui CH, Stein CM, Klein TE, Spahn C, Kwon S, Hartono JL, de Boer NK, Ahmad T, Antillon-Klussmann FG, Caudle KE, Kato M, Yeoh AEJ, Schmiegelow K, Yang JJ.   +18 more
europepmc   +1 more source

Temporal transcriptomics identifies early-response and infection-condition-specific modules guiding host-directed anti-EBOV therapeutics. [PDF]

Microbiol Spectr
Zhang N, Zheng S, Gao X, Chen D, Xu W, Wei J, Ding Q, Li W, Chiu S, Zheng Z.   +9 more
europepmc   +1 more source

The association between 6-thioguanine nucleotide levels, adalimumab exposure, immune response, and drug clearance. [PDF]

Crohns Colitis 360
Yarur A, Lo JC, Abraham B, Hanauer S, Dervieux T.   +4 more
europepmc   +1 more source

The decline of 6-thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease. [PDF]

Br J Clin Pharmacol
Bouwknegt DG, Mian P, Groen F, van den Berg-Zuiddam D, van der Meulen AE, Crouwel F, de Boer NK, Deben DS, Wong DR, Derijks LJJ, Dijkstra G, Bourgonje AR, van der Woude CJ, Visschedijk MC.   +13 more
europepmc   +1 more source

A Phase Ib/II Study of Atezolizumab in Combination with Thiopurine Therapy in Patients with Metastatic Solid Tumors and Intermediate Tumor Mutational Burden. [PDF]

Cancer Res Commun
Secher CF, Højgaard M, Spanggaard I, Schmidt AY, Guo Y, Robinson L, De Zio D, Toksvang LN, Bagger FO, Schmiegelow K, Rohrberg KS.   +10 more
europepmc   +1 more source

Severe Thiopurine-Induced Myelosuppression in a Pediatric Acute Lymphoblastic Leukemia Patient With the NUDT15 *1/*6 Genotype: A Brief Report. [PDF]

Clin Transl Sci
Fry J, Boone EC, Wang WY, John S, Lansdon LA, Farooqi MS, Yoo B, Gaedigk A, August K, Flatt TG, Ramsey LB.   +10 more
europepmc   +1 more source

Development and Validation of a Sensitive Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method for the Simultaneous Quantification of Thiopurine Nucleotides in Human Red Blood Cells. [PDF]

Cureus
Singh M, Kaushal S, Gupta K, Sood A.
europepmc   +1 more source