Results 121 to 130 of about 10,117 (217)

Pharmacological and molecular investigations on the mechanisms underlying resistance of human leukaemia cells to the antimetabolites methotrexate, 6-mercaptopurine and 6-thioguanine

, 2007
The goal of this thesis has been to elucidate the mechanisms underlying resistance to methotrexate (MTX), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG), the antimetabolites widely used in treatment of childhood leukemia, as well as to determine the ...
Alan Kambiz Fotoohi (19492087)
core  

Allopurinol increases DNA-thioguanine nucleotides during maintenance therapy in pediatric acute lymphoblastic leukemia. [PDF]

Haematologica
Källström J, Niinimäki R, Fredlund J, Vogt H, Korhonen LS, Castor A, Schmiegelow K, Thastrup M, Ek T.   +8 more
europepmc   +1 more source

EPI-SauriCas9-based mouse ovarian cancer models recapitulating pten deletion in patients. [PDF]

Commun Biol
Chen W, He P, Ding L, Lou W, Wang Y, Shi W, Fan Z, Sheng Y, Luo J, Tan Z, Wang Y, Di W, Ke X, Yu B.   +13 more
europepmc   +1 more source

Beta-Thioguanine Deoxyriboside [PDF]

, 2020
openaire   +1 more source

Development and Validation of Simultaneous Quantification of 6TGN and 6MMPN in Whole Blood Using LC-MS/MS: An Application to Therapeutic Drug Monitoring in Hematological Malignancies and in Inflammatory Bowel Diseases. [PDF]

Biomed Chromatogr
Allard M, Vignal N, Loiseau A, Sauvageon H, Médard Y, Plé A, Jacqz-Aigrain E, Mourah S, Goldwirt L.   +8 more
europepmc   +1 more source

Cytarabine-Thioguanine Regimen [PDF]

, 2020
openaire   +1 more source

Adherence to international pharmacogenomic recommendations in pediatric cancer care: a cohort analysis embedded within the MARVEL-PIC randomized trial. [PDF]

Pharmacogenomics
Chawla A, Carter S, Dyas R, Williams E, Moore C, Conyers R.   +5 more
europepmc   +1 more source

Influence of xanthine oxidase and inosine monophosphate dehydrogenase polymorphisms on 6-mercaptopurine treatment response in pediatric acute lymphoblastic leukemia. [PDF]

Sci Rep
Sabirova Z, Boucetta MTE, Bensouyad RR, Gagné V, Théorêt Y, Nava T, Leclerc JM, Laverdière C, Sinnett D, Tran TH, Krajinovic M.   +10 more
europepmc   +1 more source

Overview of Non-Cirrhotic Portal Hypertension in Pediatric Patients. [PDF]

J Clin Med
Walecha A, Sankararaman S, Radhakrishnan K.   +2 more
europepmc   +1 more source

Development and Application of an LC-MS/MS Method for Simultaneous Quantification of Azathioprine and Its Metabolites: Pharmacokinetic and Microbial Metabolism Study of a Colon-Targeted Nanoparticle. [PDF]

Pharmaceuticals (Basel)
Zhang J, Han J, Sun N, Zhu Y, Mei D, Zhao L.   +5 more
europepmc   +1 more source