Results 61 to 70 of about 268 (134)

Improving the outcomes of elderly patients with acute myeloid leukemia in a Brazilian University Hospital

Clinics, 2011
OBJECTIVE: To evaluate the outcomes of acute myeloid leukemia patients who were older than 60 years of age at the time of diagnosis following the implementation of a treatment algorithm based on age, performance status, and cytogenetic results.
Alex Freire Sandes, Juliana Correa da Costa Ribeiro, Rodrigo S. Barroso, Maria R.R. Silva, Maria L.L.F. Chauffaille   +4 more
doaj   +1 more source

Perforating dermatosis in a patient receiving azathioprine

Indian Journal of Dermatology, 2013
Azathioprine (AZA) is an imidazole derivative of mercaptopurine. It antagonizes purine metabolism, and it may inhibit synthesis of DNA, RNA, and proteins.
Emiliano Grillo, Sergio Vano-Galván, Carmen Moreno, Pedro Jaén   +3 more
doaj   +1 more source

Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling.

PLoS ONE, 2019
Dengue virus Type 2 (DENV-2) is predominant serotype causing major dengue epidemics. There are a number of studies carried out to find its effective antiviral, however to date, there is still no molecule either from peptide or small molecules released as
Maywan Hariono, Sy Bing Choi, Ros Fatihah Roslim, Mohamed Sufian Nawi, Mei Lan Tan, Ezatul Ezleen Kamarulzaman, Nornisah Mohamed, Rohana Yusof, Shatrah Othman, Noorsaadah Abd Rahman, Rozana Othman, Habibah A Wahab   +11 more
doaj   +1 more source

Gold–Thiopurine and Thioguanine Platforms for Chemotherapy and Photodynamic Therapy

ChemistryEurope
A modular family of gold(I) complexes containing the thiopurine bases 6‐mercaptopurine (6‐MP) or 6‐thioguanine (6‐TG), phosphine or N‐heterocyclic carbene ligands, and appended chromophores (dansyl or nitrobenzoxadiazole, NBD) has been synthesized to ...
Laura Agulló, Juan Carlos Pérez‐Sánchez, María Gil‐Moles, M. Concepción Gimeno   +3 more
doaj   +1 more source

Targeted Protein Degradation of NUDT5 Dissociates Catalytic Inhibition from Protein Loss in 6-Thioguanine Response

Nature Communications
6-Thioguanine (6-TG) is an FDA-approved antimetabolite drug that is widely used clinically, including for the treatment of leukemia. Its cellular effects require metabolic activation and are regulated through interactions with various proteins such as ...
Anne-Sophie M. C. Marques, Ludwig G. Bauer, Tuan-Anh Nguyen, Alejandro Gonzalez Orta, Jan-Lennart Venne, Carol Cheng, Esra Balıkçı, Yusi Liu, Barr Tivon, Alena Kroupova, Alessio Ciulli, Nir London, Stefan Kubicek, Kilian V. M. Huber   +13 more
doaj   +1 more source

Electrochemical and surface analysis investigation of corrosion inhibition performance: 6-Thioguanine, benzotriazole, and phosphate salt on simulated patinas of bronze relics

Journal of Materials Research and Technology
Organic heterocyclic corrosion inhibitors play a crucial role in the non-destructive protection of excavated bronze relics exposed to the atmosphere.
Xiaodong Li, Xu Zhu, Ailing Feng, Meimei An, Peitao Liu, Yanqing Zu   +5 more
doaj   +1 more source

Differentiating agents + low-dose chemotherapy in the management of old/poor prognosis patients with acute myeloid leukemia or myelodysplastic syndrome

Haematologica, 2004
13-cis retinoic acid + (OH)2 vitamin D3 + low-dose 6-thioguanine and cytarabine were tested in 26 patients with acute myeloid leukemia (AML) and in 4 patients with myelodysplastic syndrome (MDS) (median age 72.5), ineligible for standard chemotherapy ...
D Ferrero, E Campa, C Dellacasa, S Campana, C Foli, M Boccadoro   +5 more
doaj  

Pharmacological evaluation of drug therapies in Aicardi-Goutières syndrome: insights from patient-derived neural stem cells

Frontiers in Pharmacology
Aicardi-Goutières syndrome (AGS) is a rare genetic disorder classified among type I interferonopathies. Current pharmacological management of AGS is symptomatic and supportive, with recent clinical applications of JAK inhibitors (JAKi) and antiretroviral
Stefania Braidotti, Rosalba Monica Ferraro, Rosalba Monica Ferraro, Raffaella Franca, Elena Genova, Francesco Giambuzzi, Andrea Mancini, Valentina Marinozzi, Letizia Pugnetti, Giulia Zudeh, Alessandra Tesser, Alberto Tommasini, Alberto Tommasini, Giuliana Decorti, Giuliana Decorti, Silvia Clara Giliani, Silvia Clara Giliani, Gabriele Stocco, Gabriele Stocco   +18 more
doaj   +1 more source

Cover 1 - Thioguanine Abrogated Colitis Cancer Model

Cellular and Molecular Gastroenterology and Hepatology, 2021
doaj   +1 more source

Understanding the adsorption performance of T-G, T-BN, T-AlN, and T-GaN nanosheets toward the thioguanine anticancer drug via DFT calculations

AIP Advances
In this study, the sensitivity and reactivity of the T-graphene (T-G), T-boron nitride (T-BN), T-aluminum nitride (T-AlN), and T-gallium nitride (T-GaN) as carriers for thioguanine (Tg) anticancer drug have been explored using DFT simulations.
Md Najmus Sakib, Tanvir Ahmed, Md Adam Shafiulla, Dr. Farzana Afroj, Afiya Akter Piya, Siraj Ud Daula Shamim   +5 more
doaj   +1 more source