Results 11 to 20 of about 10,117 (217)

Excited-State Dynamics of the Thiopurine Prodrug 6-Thioguanine: Can N9-Glycosylation Affect Its Phototoxic Activity? [PDF]

Molecules, 2017
6-Thioguanine, an immunosuppressant and anticancer prodrug, has been shown to induce DNA damage and cell death following exposure to UVA radiation. Its metabolite, 6-thioguanosine, plays a major role in the prodrug’s overall photoreactivity.
Brennan Ashwood, Steffen Jockusch, Carlos E. Crespo-Hernández   +2 more
doaj   +4 more sources

The drug-survival of low-dose thioguanine in patients with inflammatory bowel disease: a retrospective observational study

Therapeutic Advances in Gastroenterology
Background: Thiopurines are commonly used to treat inflammatory bowel disease but withdrawal due to side effects are common. Thioguanine has been suggested to be better tolerated than conventional thiopurines.
Helena Gensmyr-Singer, Mårten Werner, Pontus Karling   +2 more
doaj   +2 more sources

Thioguanine Induces Apoptosis in Triple-Negative Breast Cancer by Regulating PI3K–AKT Pathway

Frontiers in Oncology, 2020
Triple-negative breast cancer (TNBC) is notoriously difficult to treat due to the lack of biological targets and poor sensitivity to conventional therapies.
Daoyu Zhang, Xinglan An, Qi Li, Xiaxia Man, Meiran Chu, Hao Li, Nan Zhang, Xiangpeng Dai, Hao Yu, Ziyi Li   +9 more
doaj   +1 more source

Au Nanoparticle Loaded with 6-Thioguanine Anticancer Drug as a New Strategy for Drug Delivery [PDF]

Journal of Nanostructures, 2018
In this study we suggested a new strategy for drug delivery of 6-thioguanine (6-TG) as a cancer drug by loading of this thiolic drug at a surface of Au nanoparticles. For this goal, we synthesized Au nanoparticle (Au/NPs) by reduction of tetrachloroauric
Hassan Karimi-Maleh, Abdollah Fallah Shojaei, Fatemeh Karimi, Khalil Tabatabaeian, shahryar shakeri   +4 more
doaj   +1 more source

Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode

Journal of Electrochemical Science and Engineering, 2021
A sensitive electrochemical sensor was developed using reduced graphene oxide RGO-Cu2O/Fe2O3 nanocomposite for 6-mercaptopurine detection based on a facile fabrication method.
Fatemeh Irannezhad, Jamileh Seyed-Yazdi, Seyedeh Hoda Hekmatara   +2 more
doaj   +1 more source

Adverse Reactions to Drugs of Special Interest in a Pediatric Oncohematology Service

Frontiers in Pharmacology, 2021
Introduction: Drugs used in oncological diseases are frequently related to adverse drug reactions (ADR). Few studies have analyzed the toxicity of cancer treatments in children in real practice.Methods: An observational, longitudinal and prospective ...
Kristopher Amaro-Hosey, Kristopher Amaro-Hosey, Immaculada Danés, Immaculada Danés, Immaculada Danés, Lourdes Vendrell, Lourdes Vendrell, Lourdes Vendrell, Laura Alonso, Laura Alonso, Berta Renedo, Luis Gros, Luis Gros, Xavier Vidal, Xavier Vidal, Xavier Vidal, Gloria Cereza, Gloria Cereza, Gloria Cereza, Antònia Agustí, Antònia Agustí, Antònia Agustí   +21 more
doaj   +1 more source

Unrealized potential of drug repositioning in Europe during COVID-19 and beyond: a physician’s perspective

Journal of Pharmaceutical Policy and Practice, 2020
Drug repositioning is the scientific strategy of investigating existing drugs for additional clinical indications. The advantages of drug repositioning are that it benefits patients and that it adds new indications to existing drugs for lower costs ...
A. B. Bayoumy, N. K. H. de Boer, A. R. Ansari, F. Crouwel, C. J. J. Mulder   +4 more
doaj   +1 more source

Exposure to thioguanine during 117 pregnancies in women with inflammatory bowel disease [PDF]

, 2022
Background: Safety of thioguanine in pregnant patients with inflammatory bowel disease [IBD] is sparsely recorded. This study was aimed to document the safety of thioguanine during pregnancy and birth.
Horjus, C.S., Asseldonk, D.P. van, Kuijvenhoven, J.P., Simsek, M., Boer, M.A. de, Bodegraven, A.A. van, Seinen, M.L., Voorn, M.M.P.J.A. van der, Visschedijk, M.C., Lutgens, M.W.M.D., Russel, M.G.V.M., Hoentjen, F., Boer, N.K. de, Kerkhof, M., Creemers, R.H., Buiter, H.J.C., Dop, W.A. van, Tack, G.J., Gilissen, L.P.L., Schaik, F.D.M. van, Boeckel, P.G.A. van, Ahmad, I., Wormmeester, L., Andel, E.M. van, Wonders, J., Boekema, P.J., Weusthuis, A.L.M., Bartelink, M.E., Crouwel, F., Maljaars, J.W.J., Mulder, C.J.J., Jharap, B.   +31 more
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6-thioguanine treatment in inflammatory bowel disease: A critical appraisal by a European 6-TG working party [PDF]

, 2006
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004,
Seiderer, J., Merwe, S. W. van der, Ochsenkühn, Thomas, Almer, S., Petritsch, W, Mulder, C. J. J, Seiderer, J, Vogelsang, H., Mulder, CJJ, Teml, A, Van Bodegraven, A. A., Teml, A., Herrlinger, K. R., Schwab, M., de Boer, NKH, Knoflach, P, van der Merwe, SW, Schwab, M, Reinisch, W., Ochsenkuhn, T, Reinisch, W, Knoflach, P., Petritsch, W., De Boer, N. K.H., De Boer, N. K. H, Van Der Merwe, S. W., Almer, Sven,, Vogelsang, H, Lukas, M., Ochsenkühn, T., van Bodegraven, AA, Lukas, M, Herrlinger, KR, Mulder, C. J.J., Bodegraven, A. A. van   +34 more
core   +1 more source

Optimizing thiopurine therapy in children with acute lymphoblastic leukemia: A promising “MINT” sequencing strategy and therapeutic “DNA-TG” monitoring

Frontiers in Pharmacology, 2022
Thiopurines, including thioguanine (TG), 6-mercaptopurine (6-MP), and azathioprine (AZA), are extensively used in clinical practice in children with acute lymphoblastic leukemia (ALL) and inflammatory bowel diseases.
Hong-Li Guo, Yue-Tao Zhao, Yue-Tao Zhao, Wei-Jun Wang, Wei-Jun Wang, Na Dong, Na Dong, Ya-Hui Hu, Yuan-Yuan Zhang, Feng Chen, Li Zhou, Tao Li   +11 more
doaj   +1 more source