Results 11 to 20 of about 14,411 (229)

Gold–Thiopurine and Thioguanine Platforms for Chemotherapy and Photodynamic Therapy

ChemistryEurope
A modular family of gold(I) complexes containing the thiopurine bases 6‐mercaptopurine (6‐MP) or 6‐thioguanine (6‐TG), phosphine or N‐heterocyclic carbene ligands, and appended chromophores (dansyl or nitrobenzoxadiazole, NBD) has been synthesized to ...
Laura Agulló, Juan Carlos Pérez‐Sánchez, María Gil‐Moles, M. Concepción Gimeno   +3 more
doaj   +2 more sources

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update. [PDF]

Clin Pharmacol Ther
Thiopurine methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) are key enzymes that catabolize thiopurines. Decreased or no‐function alleles in TPMT and NUDT15 are associated with reduced or no enzyme activity and predictive of pronounced adverse effects, including severe myelosuppression, that may occur among individuals treated with standard ...
Maillard M, Schwab M, Whirl-Carrillo M, Moyer AM, Suarez-Kurtz G, Pui CH, Stein CM, Klein TE, Spahn C, Kwon S, Hartono JL, de Boer NK, Ahmad T, Antillon-Klussmann FG, Caudle KE, Kato M, Yeoh AEJ, Schmiegelow K, Yang JJ.   +18 more
europepmc   +2 more sources

Sulfate-Directed Silver Dendrites with Enhanced Stability for Ultrasensitive SERS-Based Therapeutic Drug Monitoring. [PDF]

Adv Sci (Weinh)
This study presents sulfate‐directed silver dendrites (s‐AgDs) as oxidation‐resistant SERS substrates with long‐term stability, reproducibility, and sub‐picomolar sensitivity. Sulfate ions guide anisotropic growth and protect the surface, enabling improved performance over 7 months under ambient conditions.
Dwivedi A, Dellith J, Makarova A, El-Mashtoly SF, Popp J, Sivakov V, Cialla-May D.   +6 more
europepmc   +2 more sources

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode

Journal of Electrochemical Science and Engineering, 2021
A sensitive electrochemical sensor was developed using reduced graphene oxide RGO-Cu2O/Fe2O3 nanocomposite for 6-mercaptopurine detection based on a facile fabrication method.
Fatemeh Irannezhad, Jamileh Seyed-Yazdi, Seyedeh Hoda Hekmatara   +2 more
doaj   +1 more source

Adverse Reactions to Drugs of Special Interest in a Pediatric Oncohematology Service

Frontiers in Pharmacology, 2021
Introduction: Drugs used in oncological diseases are frequently related to adverse drug reactions (ADR). Few studies have analyzed the toxicity of cancer treatments in children in real practice.Methods: An observational, longitudinal and prospective ...
Kristopher Amaro-Hosey, Kristopher Amaro-Hosey, Immaculada Danés, Immaculada Danés, Immaculada Danés, Lourdes Vendrell, Lourdes Vendrell, Lourdes Vendrell, Laura Alonso, Laura Alonso, Berta Renedo, Luis Gros, Luis Gros, Xavier Vidal, Xavier Vidal, Xavier Vidal, Gloria Cereza, Gloria Cereza, Gloria Cereza, Antònia Agustí, Antònia Agustí, Antònia Agustí   +21 more
doaj   +1 more source

Unrealized potential of drug repositioning in Europe during COVID-19 and beyond: a physician’s perspective

Journal of Pharmaceutical Policy and Practice, 2020
Drug repositioning is the scientific strategy of investigating existing drugs for additional clinical indications. The advantages of drug repositioning are that it benefits patients and that it adds new indications to existing drugs for lower costs ...
A. B. Bayoumy, N. K. H. de Boer, A. R. Ansari, F. Crouwel, C. J. J. Mulder   +4 more
doaj   +1 more source

Research progress of NT5C2 in disease and treatment [PDF]

Jichu yixue yu linchuang, 2023
Cytosolic 5'-nucleotidase Ⅱ(cN-Ⅱ), the protein encoded by NT5C2, can catalyze the dephosphory-lation of nucleoside monophosphate and is mainly involved in the regulation of purine nucleotide pool in cells.
SHU Ling, HUO Bennian, SONG Lin
doaj   +1 more source

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. [PDF]

, 2015
Leydig cells are crucial to the production of testosterone in males. It is unknown if the cancer chemotherapeutic drug, 6-mercaptopurine (6 MP), produces Leydig cell failure among adult survivors of childhood acute lymphoblastic leukemia. Moreover, it is
Bao, Ju, Chemaitilly, Wassim, Frase, Sharon, Green, Daniel M, Janke, Laura, Lynch, John, Morgan, Jessica A, Opferman, Joseph T, Panetta, John C, Schuetz, John D, Wang, Yao, Zheng, Jie   +11 more
core   +1 more source

Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence

Nature Communications, 2021
Coagulase-negative staphylococci and Staphylococcus aureus colonize similar niches in mammals. Here, Chin et al. show that a coagulase-negative staphylococcus secretes 6-thioguanine, a purine analog that suppresses S.
Denny Chin, Mariya I. Goncheva, Ronald S. Flannagan, Shayna R. Deecker, Veronica Guariglia-Oropeza, Alexander W. Ensminger, David E. Heinrichs   +6 more
doaj   +1 more source