Results 11 to 20 of about 268 (134)
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Adverse Reactions to Drugs of Special Interest in a Pediatric Oncohematology Service
Frontiers in Pharmacology, 2021 Introduction: Drugs used in oncological diseases are frequently related to adverse drug reactions (ADR). Few studies have analyzed the toxicity of cancer treatments in children in real practice.Methods: An observational, longitudinal and prospective ...
Kristopher Amaro-Hosey +21 more
doaj +1 more source
Molecules, 2022 Understanding the primary steps following UV photoexcitation in sulphur-substituted DNA bases (thiobases) is fundamental for developing new phototherapeutic drugs.
Danielle C. Teles-Ferreira +5 more
doaj +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Frontiers in Pharmacology, 2022 Thiopurines, including thioguanine (TG), 6-mercaptopurine (6-MP), and azathioprine (AZA), are extensively used in clinical practice in children with acute lymphoblastic leukemia (ALL) and inflammatory bowel diseases.
Hong-Li Guo +11 more
doaj +1 more source
Nature Communications, 2021 Coagulase-negative staphylococci and Staphylococcus aureus colonize similar niches in mammals. Here, Chin et al. show that a coagulase-negative staphylococcus secretes 6-thioguanine, a purine analog that suppresses S.
Denny Chin +6 more
doaj +1 more source
Thiopurine 6TG treatment increases tumor immunogenicity and response to immune checkpoint blockade
OncoImmunology, 2023 Immune-checkpoint inhibitors (ICI) are highly effective in reinvigorating T cells to attack cancer. Nevertheless, a large subset of patients fails to benefit from ICI, partly due to lack of the cancer neoepitopes necessary to trigger an immune response ...
Loulieta Nazerai +14 more
doaj +1 more source
6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro
iScience, 2021 Summary: The emergence of SARS-CoV-2 has led to a global health crisis that, in addition to vaccines and immunomodulatory therapies, calls for the identification of antiviral therapeutics.
Caleb D. Swaim +10 more
doaj +1 more source
Thioguanine treatment in psoriasis
Acta Dermato-Venereologica, 1987 The efficacy of thioguanine in the treatment of severe cases of psoriasis is demonstrated. This treatment is valuable in selected cases of severe psoriasis in whom other treatment is ineffective or impossible due to side effects. The effect of thioguanine on psoriasis lesions appears to run parallel with depression of the bone marrow.
L, Molin, K, Thomsen
openaire +2 more sources
Autopsy and Case Reports, 2017 The standard therapy for some autoimmune diseases consists of a combination of corticosteroids and thiopurines. In non-responders to thiopurine drugs, the measurement of the metabolites of azathioprine, 6-thioguanine, and 6-methylmercaptopurine, can be a
Ana Luiza Vilar Guedes +7 more
doaj +1 more source