Results 161 to 170 of about 12,356 (219)
Influence of xanthine oxidase and inosine monophosphate dehydrogenase polymorphisms on 6-mercaptopurine treatment response in pediatric acute lymphoblastic leukemia. [PDF]
Sci RepSabirova Z +10 more
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Development and Application of an LC-MS/MS Method for Simultaneous Quantification of Azathioprine and Its Metabolites: Pharmacokinetic and Microbial Metabolism Study of a Colon-Targeted Nanoparticle. [PDF]
Pharmaceuticals (Basel)Zhang J +5 more
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TREATMENT OF PSORIASIS WITH 6‐THIOGUANINE
Australasian Journal of Dermatology, 1988SummaryFifty‐four patients with Psoriasis were treated with the antimetabolite, 6‐thioguanine (TG). Three were early drop‐outs due to side effects. Of 48 evaluable patients with plaque‐type lesions, mostly extensive, 79% achieved over 75% improvement as an initial response, 8% had over 50% improvement and 13% had less than 50% improvement. 65% retained
H S, Zackheim, H I, Maibach
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6-Thioguanine fromErwinia amylovora
Current Microbiology, 1986Erwinia amylovora, the etiological agent of fireblight disease, was found to produce under aerobic conditions in axenic culture 2-amino-1,7-dihydro-6H-purine-6-thion (6-thioguanine, 6-TG), easily recognized by a UV absorbance at 340 nm (pH≤7) and readily distinguished from NADH by both its acid stability and the pH dependence of its UV spectrum.
Gottfried Feistner, Carle M. Staub
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Transglycosylation Reactions of 6-Thioguanine Acyclonucleosides
Nucleosides, Nucleotides and Nucleic Acids, 20009-(2-Acetoxyethoxy)methyl-N2-acetyl-6-thoguanine (2) undergoes two different transglycosylation reactions: i) the 79 isomerization, which gives the respective 7-regioisomer (3) as the major product, ii) the 9S6 glycosyl migration, which leads to a 9,S6-disubstituted product (4). S6-Methylation completely stopped the reversibility of transglycosylation.
A, Manikowski, J, Boryski
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6-Thioguanine Metabolism in Human Erythrocytes
1991Thiopurines must undergo enzymatic conversion into a variety of nucleotide derivatives in order to display cytotoxic activity [1]; the major ones in human erythrocytes are the 6-thioguanine nucleotides [2]. These compounds derive from the immunosuppressive agent azathioprine as well as from the cytotoxic drugs 6-thioguanine and 6-mercaptopurine [3 ...
A. Lucano, C. Crifo, SALERNO, Costantino
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A sensitive assay for 6-thioguanine-resistant lymphocytes
Mutation Research Letters, 1988We have defined variants (V) resistant to 6-thioguanine (TG) by their ability to divide at least once during a 72-h incubation in a medium containing 0.2 mM TG. We blocked cytokinesis by adding cytochalasin B (CB) after 30 h in culture. The cells that had undergone nuclear division were identified by their content of 2 or more nuclei.
A, Norman, J C, Mitchell, K S, Iwamoto
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6-THIOGUANINE BIOSYNTHESIS IN ERWINIA SPECIES
Acta Horticulturae, 2014Erwinia amylovora produces a compound with an absorbance maximum at 340 nm that forms a yellow colored complex with copper. This compound was identified as 6-thioguanine, a guanine analogue that is used in chemotherapy and the treatment of inflammatory bowel disease.
A. Wensing +6 more
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Hepatic Veno-Occlusive Disease Caused by 6-Thioguanine
Annals of Internal Medicine, 1982Clinically reversible veno-occlusive disease of the liver developed in a 23-year-old man with acute lymphocytic leukemia after 10 months of maintenance therapy with 6-thioguanine. Serial liver biopsies showed the development and resolution of intense sinusoidal engorgement. Although this disease was clinically reversible, some subintimal fibrosis about
R A, Gill +4 more
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