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Network pharmacology and transcriptomics reveal androgen receptor as a potential protein target for 6PPD-quinone

Science of The Total Environment
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPD-quinone, or 6PPD-Q) has received increasing attention as an emerging hotspot contaminant. The occurrence of 6PPD-Q in dust and fine atmospheric particles indicates substantial human exposure to this toxicant but the hazards of 6PPD-Q to human health is unknown.
Xiao-Liang, Liao   +4 more
openaire   +2 more sources

Environmental fate, toxicity, and mitigation of 6PPD and 6PPD-Quinone: Current understanding and future directions

Environmental Pollution
N'-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), a widely used antioxidant in the rubber industry, has garnered global attention due to the high toxicity and ecological-health risks posed by its environmental oxidation product, 6PPD-quinone (6PPD-Q).
Jia Yi   +9 more
openaire   +2 more sources

Exploring the Temperature-Dependent Toxicity of 6PPD-quinone in Brook Trout

The increasing prevalence of tire-derived pollutants, particularly 6PPD-quinone (6PPD-q), has raised significant concerns regarding their toxic effects on aquatic organisms, especially fish. Formed from the degradation of the tire additive N,N′-dimethyl butyl-p-phenylenediamine (6PPD) through oxidation by ozone, ultraviolet light, and oxygen, 6PPD-q is
openaire   +1 more source

Spontaneous Interfacial Redox Transformation of 6PPD-Quinone on Water Microdroplets

Journal of the American Chemical Society
Jian Yan   +9 more
openaire   +1 more source

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