Results 1 to 10 of about 4,546,897 (298)

Network toxicology: A new science [PDF]

Computational Ecology and Software, 2016
Network toxicology is related to network biology. Based on my previous study (Zhang, 2016c), in present article I further outlined and defined the aims, scope, theory and methodology of network toxicology.
WenJun Zhang
doaj   +2 more sources

Network chemistry, network toxicology, network informatics, and network behavioristics: A scientific outline [PDF]

Network Biology, 2016
In present study, I proposed some new sciences: network chemistry, network toxicology, network informatics, and network behavioristics. The aims, scope and scientific foundation of these sciences are outlined.
WenJun Zhang
doaj   +2 more sources

Exploring the mechanism of Alisma orientale for the treatment of pregnancy induced hypertension and potential hepato-nephrotoxicity by using network pharmacology, network toxicology, molecular docking and molecular dynamics simulation

Frontiers in Pharmacology, 2022
Background: Pregnancy-induced Hypertension (PIH) is a disease that causes serious maternal and fetal morbidity and mortality. Alisma Orientale (AO) has a long history of use as traditional Chinese medicine therapy for PIH.
Yilin Liao, Yiling Ding, Ling Yu, Cheng Xiang, Mengyuan Yang   +4 more
doaj   +3 more sources

Integrating Network Toxicology and Untargeted Metabolomics to Identify Candidate Mechanisms and Metabolic Markers of α-Amanitin-Induced Hepatorenal Injury in Mice [PDF]

Metabolites
Background/Objectives: Mushroom poisoning is a leading cause of death from foodborne illness, and α-amanitin is its most potent toxin. However, the mechanisms and biomarkers of α-amanitin-induced hepatorenal injury remain inadequately understood. Methods:
Haiyan Cui, Yue Guo, Wang Xin, Dan Shao, Meng Hu, Tao Wang, Dan Zhang, Zhiwen Wei, Keming Yun   +8 more
doaj   +2 more sources

Assessing network-based methods in the context of system toxicology

Frontiers in Pharmacology, 2023
Introduction: Network-based methods are promising approaches in systems toxicology because they can be used to predict the effects of drugs and chemicals on health, to elucidate the mode of action of compounds, and to identify biomarkers of toxicity.
Olivier Taboureau
exaly   +4 more sources

Effective analysis of neurotoxicity and mechanisms of dioctyl terephthalate using network toxicology [PDF]

Frontiers in Neuroscience
ObjectiveDioctyl terephthalate (DOTP), a widely used plasticizer in food packaging and environmental materials, has raised concerns regarding its potential impact on human health.
Hao Tang, Ting Qin, Zhiwen Yan, Changqing Li, Qinghuan Yang, Yinghong Tang   +5 more
doaj   +2 more sources

Exploring the Potential Toxicological Mechanisms of Vine Tea on the Liver Based on Network Toxicology and Transcriptomics

Frontiers in Pharmacology, 2022
Objective: This study focuses on whether vine tea contains potentially toxic components that trigger hepatotoxicity as a mechanism of action, which further provides some reference for the consumption and guides future product development of vine tea ...
Fangyu Xiao, Jihua Qiu, Ying Zhao, Ying Zhao, Ying Zhao   +4 more
doaj   +3 more sources

Study on the Mechanism of Mesaconitine-Induced Hepatotoxicity in Rats Based on Metabonomics and Toxicology Network

Toxins, 2022
Mesaconitine (MA), one of the main diterpenoid alkaloids in Aconitum, has a variety of pharmacological effects, such as analgesia, anti-inflammation and relaxation of rat aorta. However, MA is a highly toxic ingredient.
Qian Chen, Kai Zhang, Mingjie Jiao, Jiakang Jiao, Dongling Chen, Yihui Yin, Jia Zhang, Fei Li   +7 more
doaj   +3 more sources

An in-depth exploration of the association between olanzapine, quetiapine and acute pancreatitis based on real-world datasets and network toxicology analysis

Frontiers in Pharmacology
ObjectiveTo combine pharmacovigilance and network toxicology methods to observe the acute pancreatitis (AP) following the use of antipsychotics, and potential toxic mechanisms, and to provide a reference for the safe use of drugs.MethodsThis study ...
Shuang Wang, Liying Song, Yuanjie Sun, Haonan Zhou, Jia Yao   +4 more
doaj   +3 more sources

Machine learning prediction model combined with network toxicology analysis identifies potential cardiotoxic components and mechanisms among 741 pesticides

Environment International
The usage of pesticides in agriculture is substantial, but their application may pose potential risks of physical harm. Existing network toxicology methods for analysis and prediction lack the capability for structural early-warning of toxicity and are ...
Qi Yang, Hongsheng Liu, Guiyuan Pang, Yuemi Mo, Chenglin Zhou, Meiyu Huang, Chun Luo, Erwei Hao, Lili Fan   +8 more
doaj   +3 more sources