Results 21 to 30 of about 4,546,897 (298)

Network toxicology and its application in studying exogenous chemical toxicity

环境与职业医学
With the continuous development of society, a large number of new chemicals are continuously emerging, which presents a challenge to current risk assessment and safety management of chemicals.
Yanli LIN, Zehua TAO, Zhao XIAO, Chenxu HU, Bobo YANG, Ya WANG, Rongzhu LU   +6 more
doaj   +1 more source

Medical Toxicology [PDF]

, 2021
Medical toxicology is a sub-branch of toxicology concerned with the diagnosis, management, and prevention of poisoning and other adverse effects of drugs, cosmetics, personal care products, occupational and environmental toxicants, and biological agents.

core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt

Scientific Reports
The well-established tumor suppressor, Breast Cancer Susceptibility Gene 1 (BRCA1), has been implicated in lipid metabolism and in paradoxically promoting hepatocellular carcinoma (HCC); yet its mechanistic role remains unknown.
Martha Ghebreselassie, Yoo Jin Park, Diana Nakib, David Dodington, Parasvi Patel, Sohyun Won, Anne Hakem, Razqallah Hakem, Sonya MacParland, Minna Woo   +9 more
doaj   +1 more source

Revealing the mechanisms of warfarin-induced vascular calcification through metabolomics and network toxicology

Frontiers in Pharmacology
Warfarin is widely used in clinical anticoagulation therapy, but the exact mechanism by which it induces vascular calcification (VC) remains unclear.
Zhijiao Zhang, Zhijiao Zhang, Pengyan Jia, Pengyan Jia, Chunqi Feng, Chunqi Feng, Juan Xu, Jingmin Zhang, Niuniu Bai, Weihong Chen, Weihong Chen, Weiqi Gao, Weiqi Gao, Weiqi Gao   +13 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Wearable Smart Patches on Sustainable Chitosan With Reversible Microbial Growth‐Inhibitory Properties

Advanced Functional Materials, EarlyView.
ABSTRACT Chitosan, a polysaccharide upcycled from biowaste, has long promised sustainable, biocompatible, and antimicrobial films and devices, an appeal reinforced by its recent regulatory recognition, with several chitosan‐based antibacterial dressings gaining clearance through the Food and Drug Administration's 510(k) pathway.
Jacopo Nicoletti, Kubra Kocak, Andrea Michel, Enrico Cavarzerani, Ali Raza, Petr Rohzin, Nouha Loudhaief, Saimir Frroku, Nicolò Baldovin, Hazrat Bilal, Alvise Perosa, Maurizio Selva, Flavio Rizzolio, Luca Sbuelz, Sabrina Tamburini, Domenico De Fazio, Giovanni Antonio Salvatore   +16 more
wiley   +1 more source

Pediatric bronchial ulcers induced by ibuprofen overdose: a case report combined with network toxicology to decipher potential mechanisms

Frontiers in Pharmacology
BackgroundIbuprofen overdose is commonly associated with gastrointestinal and renal toxicity; however, severe respiratory complications such as bronchial ulceration are rarely reported, and the underlying molecular mechanisms are poorly understood ...
Yixuan Huang, Guosheng Qiu, Qiongyan Li, Bin Xiong, Yiyu Chen   +4 more
doaj   +1 more source

Advancing SafeWax, A Bio‐Inspired Superhydrophobic Coating, Toward Sustainable and Climate‐Resilient Crop Protection

Advanced Functional Materials, EarlyView.
This study advances SafeWax, a bio‐inspired, fatty‐acids‐based superhydrophobic coating, by identifying an agriculturally compliant solvent and revealing how solvent‐controlled Fatty acid crystallization governs the coating's microscopic structure and performance.
Niv Ben‐Arie, Iryna Polishchuk, Franziska Tauber, Coralie Schneider, Elena Prudnikov, Alessia Calora, Silvia Milita, Simona Fermani, Mireia Alejandra Ibanez Revert, Ilaria Filippetti, Claudio Ratti, Matthias Kellermeier, Markus Rueckel, Boaz Pokroy   +13 more
wiley   +1 more source