Results 11 to 20 of about 4,546,897 (298)

An integrative pharmacovigilance, network toxicology and molecular docking study on drug-induced cheilitis [PDF]

Frontiers in Pharmacology
ObjectiveDrug-induced cheilitis represents an inadequately comprehended adverse reaction, with limited understanding of its underlying mechanisms. This study employs an integrative approach, combining pharmacovigilance, network toxicology, and molecular ...
Xuefeng Wang, Shangzhi Han, Yingxue Huang, Lei Zhang, Xue Li, Liqin Yang, Yanbo Zhang   +6 more
doaj   +2 more sources

Combined Analysis of Network Toxicology and Metabolomics Uncovers the Potential Mechanisms Underlying Neodymium Oxide-Induced Pulmonary Fibrosis [PDF]

Toxics
Rare earth element-related occupational and environmental health risks have received increasing attention, but the molecular mechanisms underlying neodymium oxide (Nd2O3)-induced pulmonary fibrosis remain unclear.
Kai Wu, Yi Zhang, Xi Chen, Yanhong Dong, Suhua Wang, Yanrong Gao   +5 more
doaj   +2 more sources

Efficient analysis of adverse drug events and toxicological mechanisms of newly marketed drugs by integrating pharmacovigilance and network toxicology: selumetinib as an example

Frontiers in Pharmacology
ObjectiveTo integrate pharmacovigilance and network toxicology methods to explore the potential adverse drug events (ADEs) and toxic mechanisms of selumetinib, and to provide a reference for quickly understanding the safety and toxicological mechanisms ...
Rui Xiong, Jing Lei, Lu Wang, Shipeng Zhang, Hengxu Liu, Hongping Wang, Tao Liu, Xiaodan Lai   +7 more
doaj   +3 more sources

Arecoline-Induced Hepatotoxicity in Rats: Screening of Abnormal Metabolic Markers and Potential Mechanisms

Toxics, 2023
Arecoline is a pyridine alkaloid derived from areca nut in the Arecaceae family. It has extensive medicinal activity, such as analgesic, anti-inflammatory, and anti-allergic. However, the toxicity of Arecoline limits its application. Most current studies
Jing Sun, Kai Zhang, Yihui Yin, Yunpeng Qi, Siyuan Li, Haonan Sun, Min Luo, Yixuan Sun, Zhiying Yu, Jie Yang, Jingjing Wu, Lijuan Chen, Wenjuan Xu, Ling Dong   +13 more
doaj   +1 more source

Diagnostic Test Criteria for HLA Genotyping to Prevent Drug Hypersensitivity Reactions: A Systematic Review of Actionable HLA Recommendations in CPIC and DPWG Guidelines

Frontiers in Pharmacology, 2020
IntroductionCertain HLA variants are associated with an increased risk of hypersensitivity reactions to specific drugs. Both the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Dutch Pharmacogenetics Working Group (DPWG) have issued ...
Lisanne E. N. Manson, Lisanne E. N. Manson, Jesse J. Swen, Jesse J. Swen, Henk-Jan Guchelaar, Henk-Jan Guchelaar   +5 more
doaj   +1 more source

Predictive toxicology and ecotoxicology within the ANTIOPES network [PDF]

Environmental Science and Pollution Research, 2013
The ANTIOPES network has organized on March 19th and 20th 2012 a Symposium in Avignon which has been attended by 150 participants. The scientific meeting was focused on one of its main project, the predictive ecotoxicology and toxicology, in order to produce a comprehensive update on technical and scientific innovations required for main challenges of ...
Emmanuel, Lemazurier, Francelyne, Marano
openaire   +2 more sources

Collaborative development of predictive toxicology applications [PDF]

, 2010
OpenTox provides an interoperable, standards-based Framework for the support of predictive toxicology data management, algorithms, modelling, validation and reporting.
Melagraki, G, Ghosh, I., Tcheremenskaia, O., Alexey Zakharov, Gütlein, M., Afantitis, A, Karwath, A., Helma, C, Wicker Joerg, Lagunin Alexey, Ivelina Nikolova, Poroikov, V., Hardy, B, Douglas, N., Patel, Hitesh, Buchwald, Fabian, Wicker, J., Escher, Sylvia, Hardy, B., Lagunin, A., Helma Christoph, Buchwald, F, Maunz, Andreas, Poroikov Vladimir, Martin Gutlein, Gutlein, Martin, Jeliazkov Vedrin, Girschick, T., Douglas, N, Georgia Melagraki, Jeliazkov, V., Druzhilovsky, Dmitry, Sylvia Escher, Kramer, S, Tcheremenskaia Olga, Melagraki, G., Poroikov, Vladimir, Romualdo Benigni, Benigni, R., Fabian Buchwald, Gallagher, D., Nikolova Ivelina, Filimonov, D, Karwath Andreas, Rautenberg, M., Dmitry Filimonov, Natalia Skvortsova, Tobias Girschick, Jeliazkova, N., Gütlein Martin, Ghosh Indira, Karwath, A, Micha Rautenberg, Nikolova, Ivelina, Filimonov, D., Chawla, Sunil, Filimonov Dmitry, Gallagher, D, Zakharov, A., Rautenberg, Micha, Gloriozova Tatyana, Alexey Lagunin, Indira Ghosh, Surajit Ray, Filimonov, Dmitry, Hardy, Barry J., Girschick Tobias, Lagunin, A, Skvortsova, N, Gloriozova, T., Escher, S, Kramer Stefan, Jeliazkova, N, Girschick, T, Tcheremenskaia, Olga, Vladimir Poroikov, Ray, Surajit, Buchwald Fabian, Sopasakis, P, Antreas Afantitis, Melagraki Georgia, Ray, S, Nina Jeliazkova, Novikov, Sergey, Maunz, A., Joerg Wicker, Skvortsova Natalia, Nicki Douglas, Helma, Christoph, Gutlein, M, Zakharov, A, Girschick, Tobias, Hardy Barry, Karwath, Andreas; id_orcid, Ray Surajit, Andreas Karwath, Hardy, Barry, Druzhilovsky Dmitry, Nikolova, I., Maunz, A, Kramer, S., Tcheremenskaia, O, Sopasakis, P., Nikolova, I, Sopasakis, Pantelis, Jeliazkova Nina, Rautenberg Micha, Patel Hitesh, Druzhilovsky, D., Afantitis, A., Zakharov, Alexey V., Zakharov Alexey, Escher, S., Druzhilovsky, D, Melagraki, Georgia, Douglas, Nicki, Sopasakis, Pantelis; id_orcid, Gloriozova, T, Jeliazkova, Nina, Haralambos Sarimveis, Helma, C., Tatyana Gloriozova, Benigni Romualdo, Patel, H., Sopasakis Pantelis, Skvortsova, Natalia, Rautenberg, M, Afantitis Antreas, Barry Hardy, Pantelis Sopasakis, Gallagher, David, Sarimveis, Haralambos, Karwath, Andreas, Jeliazkov, V, Afantitis, Antreas, Buchwald, F., Benigni, R, Wicker, Joerg, Ray, S., Lagunin, Alexey, Sarimveis, H., Benigni, Romualdo, Kramer, Stefan, Sergey Novikov, Novikov, S., Zakharov, Alexey, Chawla, S., Sarimveis Haralambos, Novikov, S, Stefan Kramer, Ghosh, Indira, Olga Tcheremenskaia, Wicker, Jörg, Novikov Sergey, Escher Sylvia, Vedrin Jeliazkov, Hitesh Patel, Poroikov, V, Chawla, S, Andreas Maunz, Sunil Chawla, Jeliazkov, Vedrin, Patel, H, Gallagher David, Sarimveis, H, Dmitry Druzhilovsky, Wicker, J, Christoph Helma, Chawla Sunil, Maunz Andreas, Ghosh, I, Gloriozova, Tatyana, Douglas Nicki, David Gallagher, Skvortsova, N.   +174 more
core   +1 more source

Information Sources and Support Networks in Toxicology [PDF]

Journal of the American College of Toxicology, 1989
This paper compiles sources of information dealing with environmental toxicology. Special emphasis has been put on information available from various computer databases and support networks. The information compiled will be useful for professionals entering the regulatory agencies as toxicologists or environmental health scientists.
K. S. Sidhu, T. M. Stewart, E. W. Nelton
openaire   +1 more source

Nicotine-induced immune escape mechanisms in lung adenocarcinoma: ceRNA network toxicology, and molecular dynamics simulations [PDF]

PeerJ
Lung adenocarcinoma (LUAD), the most common subtype of lung cancer and a leading cause of cancer-related deaths, is strongly associated with cigarette smoking and nicotine exposure.
Yijing Zhong, Quhuan Li, Hailin Li, Xingyu Liu, Xiaomeng Chen, Jiao Li, Yu Zhang, Ruiquan Xu   +7 more
doaj   +2 more sources

A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity

iScience, 2018
Summary: Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent off-target toxicity in these chemicals has often required extensive chemical testing in ...
Joseph Leedale, Kieran J. Sharkey, Helen E. Colley, Áine M. Norton, David Peeney, Chantelle L. Mason, Jean G. Sathish, Craig Murdoch, Parveen Sharma, Steven D. Webb   +9 more
doaj   +1 more source