Results 31 to 40 of about 4,546,897 (298)

Network Toxicology and Molecular Docking Reveal the Toxicological Mechanisms of DEHP in Bone Diseases

International Journal of Molecular Sciences
Di(2-ethylhexyl) phthalate (DEHP), a widely employed exogenous plasticizer, has become pervasive in the environment and living organisms due to its extensive use in food packaging, medical devices, and daily consumer products, and is established as a typical endocrine-disrupting chemical.
Zhonghao Fan, Haitao Du, Xinyi Zhou, Cheng Wang, Mengru Zhang, Tiefeng Sun, Yi Wang, Ping Wang   +7 more
openaire   +2 more sources

Rare‐Earth–Functionalized Carbon Dot Hydrogels as Mechanically Robust Antibacterial Wound Dressings

Advanced Healthcare Materials, EarlyView.
The schematic depicts a dynamically cross‐linked PVA hydrogel network in which reversible borate ester bonds and hydrogen‐bonding interactions integrate lanthanum‐doped carbon dots (La‐CDs) and dipotassium glycyrrhizinate (DPG) to form a mechanically robust, multifunctional matrix.
Shih‐Han Tsai, Ramadhass Keerthika Devi, Muthusankar Ganesan, Guo‐Ping Chang Chien, Chun Che Lin   +4 more
wiley   +1 more source

Network toxicology and machine learning reveal the toxicological impact of Bisphenol A exposure on osteoarthritis

Medicine
Osteoarthritis (OA) is the most common chronic degenerative joint disease, and increasing evidence suggests that environmental exposures play a crucial role in its onset and progression. Bisphenol A (BPA), a widespread environmental endocrine disruptor, has been associated with inflammation, oxidative stress, and abnormal bone metabolism; however, its ...
Jing Tan, Daobin Han
openaire   +3 more sources

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

Analyzing the potential targets and mechanisms of liver damage induced by acetyl tributyl citrate plasticizer using network toxicology, molecular docking and in vitro experiments

Frontiers in Pharmacology
BackgroundAcetyl tributyl citrate (ATBC) may have adverse effects on liver health; however, the underlying mechanisms and pathophysiology remain unclear.
Dong-qun Guo, Yu-ming Fang, Zhen-dong Sun, Ya-fen Zeng, Gui-dan Wang, Jin-wei Liang   +5 more
doaj   +1 more source

Polyphenol‐Inspired Materials for Agricultural Applications

Advanced Materials, EarlyView.
This review outlines the use of polyphenol‐inspired materials for sustainable agriculture, highlighting their molecular design, interfacial assembly, structure–property relationships, and prospects toward precision agriculture, climate resilience, ecosystem protection, and circular bioeconomy strategies.
Haofu Liu, Omid Mazaheri, Zhixing Lin, Tianzheng Wang, Jingqu Chen, Yuang Gu, Xia Liang, Deli Chen, Frank Caruso   +8 more
wiley   +1 more source

The impact of phthalates on asthma and chronic obstructive pulmonary disease: a comprehensive analysis based on network toxicology and molecular docking

Frontiers in Pharmacology
IntroductionPhthalates (PAEs) are widely used plasticizers in polyvinyl chloride (PVC) products since the 1930s, and recent research indicates a significant association between exposure to these substances and the development and progression of asthma ...
Ren Li, Ren Li, Ren Li, Bingqing Zheng, Bingqing Zheng, Bingqing Zheng, Yuqiong Zhang, Yuqiong Zhang, Yuqiong Zhang, Lu He, Chaomin Ren, Chaomin Ren, Chaomin Ren, Linlin Guan, Linlin Guan, Linlin Guan, Huan Yang, Huan Yang, Huan Yang, Jiayu Tian, Jiayu Tian, Jiayu Tian, Xingyi Chen, Xingyi Chen, Xingyi Chen, Dongxing Shi, Dongxing Shi, Dongxing Shi, Lifang Zhao, Lifang Zhao, Lifang Zhao, Zhihong Zhang, Zhihong Zhang, Zhihong Zhang   +33 more
doaj   +1 more source

S‐Nitrosothiols as Thiol‐Protecting Groups for Controlled Thiol‐Maleimide Crosslinking of Homogeneous Soft Hydrogels

Advanced Materials, EarlyView.
Rapid thiol‐maleimide addition frequently outpaces mixing, resulting in heterogeneous hydrogels. S‐nitrosothiols act as thiol‐protecting groups, allowing uniform mixing with maleimide‐functionalized polymers before gelation. Sodium thiosulfate or sodium ascorbate then regenerates thiols on demand, triggering controlled thiol‐maleimide crosslinking ...
Julian A. Serna, Michelle J. Iwohn, Maximilian Seifermann, Stefan Heißler, Maike Schliephake, Franziska Dopp, Claudia Muhle‐Goll, Pavel A. Levkin   +7 more
wiley   +1 more source

Air pollution-related immune gene prognostic signature for hepatocellular carcinoma: network toxicology, machine learning and multi-omics analysis

Frontiers in Immunology
BackgroundAir pollution may crosstalk with immune system to promote hepatocellular carcinoma (HCC) development, but its precise mechanisms and prognostic significance remain unclear.ObjectiveThis study aims to construct a prognostic signature for HCC ...
Lei Pu, Xiaoyan Zhang, Cheng Pu, Peng Sun   +3 more
doaj   +1 more source