Transcriptomic and Proteomic Insights into 6PPD/6PPD-Q Induced Oxidative Stress in Black-Spotted Frogs [PDF]
AntioxidantsN-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPD-Q) can have lethal effects on aquatic organisms, interfering with gene expression and protein content in aquatic animals.
Wenhui Sun +5 more
doaj +5 more sources
Chronic toxicity mechanisms of 6PPD and 6PPD-Quinone in zebrafish [PDF]
Environmental Science and EcotechnologyN-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its oxidation derivative, 6PPD-quinone (6PPDQ), have been extensively detected in environmental and biological samples, raising significant concerns regarding their chronic aquatic toxicity at
Fang Jiao +7 more
doaj +5 more sources
Environment InternationalThe pervassive release of tire and road wear particles (TRWPs) introduces the tire additive 6PPD and its biologically active derivative, 6PPD-quinone (6PPD-Q), into the environment, with soil serving as the primary sink. However, at present their fate in
Nathan Sy, Jay Gan, Dahang Shen
exaly +6 more sources
Environment InternationalThe widely used rubber antioxidant N-(1,3-Dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) and its ozonated product, 6PPD-quinone (6PPD-Q), are highly toxic to aquatic life, yet understanding on their environmental behaviors is limited.
Jing Wei, Wenyi Xie, Tao Long
exaly +6 more sources
Molecular Mechanisms of 6PPD and 6PPD-Q Toxicity in Neurodegenerative Diseases: A Network Toxicology and Experimental Validation Study [PDF]
Toxics6PPD is a widely used tire antioxidant that readily transforms into its more toxic ozonation product, 6PPD-quinone (6PPD-Q). Both compounds are emerging environmental contaminants with potential neurotoxic risks, yet their molecular mechanisms in ...
Ze Li +4 more
doaj +3 more sources
Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids [PDF]
Biochemistry and Biophysics ReportsThe tire rubber antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPD-Q) were recently found in human bodies.
Daniel J. Yeisley +7 more
doaj +3 more sources
Nanoplastics amplify 6PPD ocular toxicity in zebrafish [PDF]
Environmental Science and EcotechnologyNanoplastics and tire-derived chemicals are ubiquitous co-pollutants in aquatic environments, originating from road runoff and posing potential risks to vertebrate development through enhanced bioavailability and synergistic toxicity.
Jian Lin +7 more
doaj +4 more sources
Not Just a Fish Killer: Multi-Organ Toxicity and Mechanisms of 6PPD-Quinone [PDF]
Toxics6PPD-Quinone (6PPD-Q) is a tire derivative formed by the oxidation of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), a commonly used antioxidant and ozone stabilizer in rubber products, and has emerged as a significant environmental concern ...
Pinzhi Dong +7 more
doaj +2 more sources
Potential hazard assessment of 6PPD-quinone in the context of ulcerative colitis: network toxicology, machine learning, transcriptomic analysis, and preliminary In vivo validation [PDF]
Frontiers in ImmunologyBackgroundThe ubiquitous tire-derived pollutant 6PPD-quinone (6PPD-Q) poses potential systemic health risks, yet its toxicological impact on the intestinal tract, particularly in the context of ulcerative colitis (UC), remains largely unknown. This study
Jingyi Li +5 more
doaj +2 more sources
Advances in Analytical Determination Methods and Toxicity and Health Risk Assessment of 6PPD and Its Transformation Products in Food [PDF]
ToxicsN-(1,3-Dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) is a member of the p-phenylenediamines (PPDs), recognized as a highly effective antioxidant. It has been extensively employed in the automotive tire manufacturing industry, and plays a critical ...
Bolin Liu +5 more
doaj +2 more sources