Transcriptomic and Proteomic Insights into 6PPD/6PPD-Q Induced Oxidative Stress in Black-Spotted Frogs [PDF]
AntioxidantsN-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPD-Q) can have lethal effects on aquatic organisms, interfering with gene expression and protein content in aquatic animals.
Wenhui Sun +5 more
doaj +5 more sources
Environmental Occurrence, Influencing Factors, and Toxic Effects of 6PPD-Q [PDF]
ToxicsThe antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is widely incorporated into tires to extend their service life. However, in the presence of ozone, it is readily transformed into N-(1,3-dimethylbutyl)-N′-phenyl-p-benzoquinone ...
Tengwen Yin +4 more
doaj +5 more sources
Environment InternationalThe widely used rubber antioxidant N-(1,3-Dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) and its ozonated product, 6PPD-quinone (6PPD-Q), are highly toxic to aquatic life, yet understanding on their environmental behaviors is limited.
Jing Wei, Wenyi Xie, Tao Long
exaly +6 more sources
Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids [PDF]
Biochemistry and Biophysics ReportsThe tire rubber antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPD-Q) were recently found in human bodies.
Daniel J. Yeisley +7 more
doaj +3 more sources
Molecular Mechanisms of 6PPD and 6PPD-Q Toxicity in Neurodegenerative Diseases: A Network Toxicology and Experimental Validation Study [PDF]
Toxics6PPD is a widely used tire antioxidant that readily transforms into its more toxic ozonation product, 6PPD-quinone (6PPD-Q). Both compounds are emerging environmental contaminants with potential neurotoxic risks, yet their molecular mechanisms in ...
Ze Li +4 more
doaj +3 more sources
What research exists on the presence of 6PPD-Q in different environmental media? A systematic map protocol [PDF]
Environmental EvidenceBackground Automobiles are ubiquitous in the modern world, and chemicals leaching from car tires and from the tire wear particles produced during driving can be toxic to the environment, particularly in aquatic ecosystems.
Sultan Aljohani +2 more
doaj +6 more sources
Advances in Analytical Determination Methods and Toxicity and Health Risk Assessment of 6PPD and Its Transformation Products in Food [PDF]
ToxicsN-(1,3-Dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) is a member of the p-phenylenediamines (PPDs), recognized as a highly effective antioxidant. It has been extensively employed in the automotive tire manufacturing industry, and plays a critical ...
Bolin Liu +5 more
doaj +3 more sources
Environment InternationalThe widespread occurrence of N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q) in aquatic environments and its hazards to aquatic species underscore the necessity of comprehending its environmental fate.
Xiaopeng Yan +7 more
exaly +5 more sources
Potential hazard assessment of 6PPD-quinone in the context of ulcerative colitis: network toxicology, machine learning, transcriptomic analysis, and preliminary In vivo validation [PDF]
Frontiers in ImmunologyBackgroundThe ubiquitous tire-derived pollutant 6PPD-quinone (6PPD-Q) poses potential systemic health risks, yet its toxicological impact on the intestinal tract, particularly in the context of ulcerative colitis (UC), remains largely unknown. This study
Jingyi Li +5 more
doaj +2 more sources
Not Just a Fish Killer: Multi-Organ Toxicity and Mechanisms of 6PPD-Quinone [PDF]
Toxics6PPD-Quinone (6PPD-Q) is a tire derivative formed by the oxidation of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), a commonly used antioxidant and ozone stabilizer in rubber products, and has emerged as a significant environmental concern ...
Pinzhi Dong +7 more
doaj +2 more sources