Residues of 6PPD-Q in the Aquatic Environment and Toxicity to Aquatic Organisms: A Review
FishesN-(1,3-dimethylbutyl)-N’-phenyl-p-benzoquinone (6PPD-Q) is an emerging environmental contaminant that is widely distributed in aquatic environments and presents significant toxicological risks to aquatic organisms.
Chaoju Li +5 more
doaj +3 more sources
Environment InternationalThe pervassive release of tire and road wear particles (TRWPs) introduces the tire additive 6PPD and its biologically active derivative, 6PPD-quinone (6PPD-Q), into the environment, with soil serving as the primary sink. However, at present their fate in
Nathan Sy, Jay Gan, Dahang Shen
exaly +4 more sources
Environment InternationalOutdoor workers who are exposed to traffic-derived pollutants often suffer from a range of diseases, with liver disease being particularly notable. Recently, a rubber stabilizing additive antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine ...
Zhihao Qin +8 more
doaj +5 more sources
Adverse effects of 6PPD-quinone bioaccumulation at environmentally relevant concentrations on Cyprinus carpio growth and development [PDF]
Scientific ReportsWith industrial advancements, the development and use of various additive substances have increased, leading to their potential release into the environment during use and disposal. As a primary tyre additive, the rubber additive, N1-(4-methylpentan-2-yl)
Yooeun Chae +7 more
doaj +3 more sources
ToxicsN-(1,3-Dimethyl butyl)-N′-phenyl-phenylenediamine-quinone (6PPD-Q) is a derivative of the widely used rubber tire antioxidant 6PPD, which was first found to be acutely toxic to coho salmon. Subsequent studies showed that 6PPD-Q had species-specific acute
Yunqing Qi +5 more
doaj +2 more sources
Associations of Serum Substituted p-Phenylenediamine-Derived Quinone Levels with Oxidative Stress and Immune Function Biomarkers in a General Adult Population [PDF]
ToxicsSubstituted p-phenylenediamine-quinones (PPD-Qs) are commonly employed as antioxidants in varying rubbers with potential biotoxicological implications in humans.
Dandan Zhou +8 more
doaj +2 more sources
Associations Between Human Exposure to Substituted p-Phenylenediamine-Derived Quinones and Colorectal Cancer Risk [PDF]
ToxicsSubstituted p-phenylenediamine-derived quinones (PPD-Qs) have become ubiquitous contaminants in various environmental matrices. However, the understanding of the potential health risks posed by human exposure to these emerging compounds remains limited ...
Zhenling Fu +3 more
doaj +2 more sources
Environment InternationalN-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) is commonly used in rubber compounds as antioxidants to protect against degradation from heat, oxygen, and ozone exposure.
Yang Jiang +4 more
doaj +2 more sources
6PPD-Q exposure disrupts intestinal homeostasis and impairs skeletal muscle function in mice
Ecotoxicology and Environmental Safety6PPD-Q is an emerging tire-derived contaminant, but its mammalian toxicological mechanisms and inter-organ effects remain poorly understood. Because oral exposure directly interfaces with the intestine, we investigated whether 6PPD-Q disrupts intestinal ...
Xudong Yi +15 more
doaj +2 more sources
6PPD-quinone exposure and Alzheimer’s disease: insights from integrative network pharmacology, transcriptomics, machine learning, and molecular docking [PDF]
Open MedicineTo systematically investigate the molecular associations between 6PPD-quinone (6PPD-Q), an environmental transformation product of the tire antioxidant 6PPD, and Alzheimer’s disease (AD) pathogenesis.
Zhang Chun, Zhang Jingqi
doaj +2 more sources