Investigating the Potential Effects of 6PPDQ on Prostate Cancer Through Network Toxicology and Molecular Docking [PDF]
Toxics(1) Background: N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPDQ), as a newly discovered environmental toxin, has been found more frequently in our living conditions.
Shengde Wu
exaly +7 more sources
Environmental and Human Health Risks of 6PPD and 6PPDQ: Assessment and Implications [PDF]
ToxicsThis review aims to synthesize current knowledge on the environmental contaminants N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its quinone derivative (6PPDQ) derived from tire wear particles (TWPs), focusing on their environmental ...
Sainan Zhang +5 more
doaj +5 more sources
Emerging ContaminantsN-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is a widely used antioxidant and antiozonant in vehicle tires, commonly used to enhance rubber durability and performance. However, its environmental transformation, particularly into 6PPD-Quinone
Gangadhar Andaluri
exaly +5 more sources
Chronic toxicity mechanisms of 6PPD and 6PPD-Quinone in zebrafish [PDF]
Environmental Science and EcotechnologyN-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its oxidation derivative, 6PPD-quinone (6PPDQ), have been extensively detected in environmental and biological samples, raising significant concerns regarding their chronic aquatic toxicity at
Fang Jiao +7 more
doaj +3 more sources
6PPDQ Exposure Exacerbates Seizure-Induced Neuronal Damage via the TP53/Nrf2 Axis: An Integrated Strategy Combining Network Toxicology and Experimental Validation [PDF]
ToxicsAs an emerging tire wear-derived environmental contaminant, 6PPD-quinone (6PPDQ) has raised significant concerns regarding its neurotoxic potential, particularly for children exposed to recycled tire crumb rubber in playgrounds.
Ruijin Xie +9 more
doaj +3 more sources
6PPD and 6PPDQ embryonic exposure induced distinct developmental neurotoxicity in zebrafish
Ecotoxicology and Environmental SafetyThe ecological risks of tire antioxidant 6PPD and its transformed metabolite 6PPD-quinone (6PPDQ) have received high attention. The present study evaluated the developmental neurotoxicity and potential mechanisms under 6PPD or 6PPDQ embryonic exposures ...
Da Sun, Jiangfei Chen
exaly +5 more sources
Spatiotemporal distribution and environmental risk assessment of 6PPDQ in the Schuylkill River
Emerging ContaminantsTire wear particles (TWPs) and associated contaminants, including microplastics, benzothiazoles, polycyclic aromatic hydrocarbons (PAHs), N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), its byproduct 6PPD-Quinone (6PPDQ), and heavy metals, are
Gangadhar Andaluri
exaly +4 more sources
Environment InternationalPrevious research has demonstrated acute toxicity of 6PPD-quinone (6PPDQ), the ozonation product of tire-manufacturing additive 6PPD; however, chronic effects on aquatic organisms under real-world conditions remain unclear.
Yao Dang, Chuan Yi, Mingdeng Xiang
exaly +5 more sources
What evidence exists on the environmental occurrence and toxic effects of the tire additive 6PPD: a systematic map protocol [PDF]
Environmental EvidenceBackground The tire additive N-(1,3-dimethylbutyl)-Nʹ-phenyl-p-phenylenediamine (6PPD) is widely produced in large volumes as a rubber antidegradant. This chemical can be released into the environment throughout the lifecycle of rubber products. Recently,
Katryna J. Seabrook +10 more
doaj +2 more sources
Acute Toxicity Testing of the Tire Rubber-Derived Chemical 6PPD-quinone on Atlantic Salmon (Salmo salar) and Brown Trout (Salmo trutta). [PDF]
Environ Toxicol Chem, 2022 Abstract Recent identification of 6PPD‐quinone as the chemical causing acute toxicity in coho salmon has led to substantial concern regarding the toxicity of this contaminant for other aquatic species. Environmental occurrence of 6PPD‐quinone is probably high, because it is an oxidation product of a common tire rubber additive. Research on 6PPD‐quinone
Foldvik A +3 more
europepmc +2 more sources