Results 41 to 50 of about 216 (131)

H/D Exchange Coupled with ²H‑labeled Stable Isotope-Assisted Metabolomics Discover Transformation Products of Contaminants of Emerging Concern

, 2023
Stable isotope-assisted metabolomics (SIAM) is a powerful tool for discovering transformation products (TPs) of contaminants. Nevertheless, the high cost or lack of isotope-labeled analytes limits its application.
Jiahui Wang (746367), Man Peng, Xiaole Han (799621), Siyue Li (275761), Xiaoyu Yan (500545), Siyue Li, Ziyu Chen, Yiguang Qian, Xiaohui Ou, Yiguang Qian (647051), Shenghua Zhang, Ziyu Chen (1903933), Jie Sun, Xiaole Han, Xiaoyu Yan, Xiaohui Ou (16826131), Man Peng (16826128), Ke Chen (73307), Shenghua Zhang (1680385), Ke Chen, Jiahui Wang, Jie Sun (74648)   +21 more
core   +2 more sources

6PPD-Q exposure disrupts intestinal homeostasis and impairs skeletal muscle function in mice

Ecotoxicology and Environmental Safety
6PPD-Q is an emerging tire-derived contaminant, but its mammalian toxicological mechanisms and inter-organ effects remain poorly understood. Because oral exposure directly interfaces with the intestine, we investigated whether 6PPD-Q disrupts intestinal ...
Xudong Yi, Yaxuan Zhang, Ke Yang, Bingzhi Li, Fang Liu, Geru Tian, Jie Zhang, Tao Yan, Juan Li, Wenfeng Li, Long li, Ruoxi Jing, Zhencang Zhang, Xinxin Qiu, Jiaying Xiao, Wanrong Zhang   +15 more
doaj   +1 more source

Chemoproteomics Prioritizes Mitochondrial ADP/ATP Translocase as a Candidate Target Associated with 6PPDQ-Induced Respiratory Toxicity in Rainbow Trout Gill

6PPD quinone (6PPDQ) is an emerging contaminant that induces acute respiratory toxicity in rainbow trout (Oncorhynchus mykiss), yet its underlying molecular mechanisms remain poorly understood. In the present study, short-term in vivo exposure of rainbow
Wei Zhang, Jing You, Xiqing Zhang, Xiaojian Shao, Xiumei Xing   +4 more
core   +1 more source

6PPDQ Exposure Induces Mammary Developmental Damage through Mitochondrial Dysfunction Mediated by the p38 MAPK Signaling Pathway

N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPDQ), the primary oxidative metabolite of rubber antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), is an emerging global contaminant with multiorgan toxicity and has been ...
Caihong Wang, Yunmeng Song, Zhipeng Fu, Mingqiang Ma, Nan Zhang, Yuanxiang Jin   +5 more
core   +1 more source

Global multi-media distribution and transport of 6PPD and 6PPD-Q: a source-to-sink continuum

Environment International
The tire antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its toxic oxidation product 6PPD-quinone (6PPD-Q) are widely detected, yet their global cross-media distribution, transport patterns, and macroscopic anthropogenic ...
Yao Li, Qing Zhang, Wu Wen, Zhuangzhuang Zhang, Wenhao Xu, Yuan Xin, Jie Zhang, Xinghui Xia   +7 more
doaj   +1 more source

Multidimensional measurement of 6-PPDQ exposure aggravates myocardial injury in mice

Environmental Sciences Europe
Background The toxicity of the contaminant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6-PPDQ) is a growing concern. However, its potential myocardial toxicity remains unclear.
Huichao Pan, Jun Zhou, Lei Song, Zhongqing Xu, Min Zhang   +4 more
doaj   +1 more source

Residues of 6PPD-Q in the Aquatic Environment and Toxicity to Aquatic Organisms: A Review

Fishes
N-(1,3-dimethylbutyl)-N’-phenyl-p-benzoquinone (6PPD-Q) is an emerging environmental contaminant that is widely distributed in aquatic environments and presents significant toxicological risks to aquatic organisms.
Chaoju Li, Yuanqiang Yang, Zikun Tian, Zhiqiu Huang, Yi Huang, Yuhang Hong   +5 more
doaj   +1 more source

Role of aryl hydrocarbon receptor in toxic effects of emerging environmental pollutants

环境与职业医学
In recent years, an increasing number of emerging environmental pollutants have been identified, garnering widespread attention. Many of these pollutants are characterized by their environmental persistence and bioaccumulation, which pose significant ...
Mingxuan ZHANG, Baoqiang FU, Jinhao LI, Kang WANG, Yan JIANG, Tao CHEN   +5 more
doaj   +1 more source

Tyre-derived ecotoxicity: Differentiating the effects from particles and chemical leachates on the blue mussel Mytilus edulis

Environmental Chemistry and Ecotoxicology
Tyre particles contain complex chemical additives that can leach out into the aquatic environment, posing potential risks to marine organisms. Despite growing evidence of adverse effects, the relative importance of particle-driven versus chemically ...
M. Elisabetta Michelangeli, Steven Brooks, Sebastian Kuehr, Emelie Forsman, Elisabeth S. Rødland, Sicco H. Brandsma, Maria Margalef, Manuel Heinzelmann, Davide Spanu, Jan Thomas Rundberget, Tânia Gomes   +10 more
doaj   +1 more source

Phenylenediamines and quinone derivatives: analytical advances

Reviews in Analytical Chemistry
Phenylenediamines (PDs) and their N,N′-substituted derivatives (PPDs) are widely used antiozonants in rubber and polymer manufacturing, with significant release into the environment via tire wear particles.
Lucarini Fiorella, Staedler Davide
doaj   +1 more source