Results 51 to 60 of about 216 (131)

Correlation between 6PPD-Q and immune along with metabolic dysregulation induced liver lesions in outdoor workers

Environment International
Outdoor workers who are exposed to traffic-derived pollutants often suffer from a range of diseases, with liver disease being particularly notable. Recently, a rubber stabilizing additive antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine ...
Zhihao Qin, Yan Li, Yanlan Qin, Zhongli Chen, Jinsong Guo, Fang Fang, Andreas Schäffer, Henner Hollert, Ying Shao   +8 more
doaj   +1 more source

Urine Excretion, Organ Distribution, and Placental Transfer of 6PPD and 6PPD-Quinone in Mice and Potential Developmental Toxicity through Nuclear Receptor Pathways

The rubber antioxidant 6PPD has gained significant attention due to its highly toxic transformation product, 6PPD-quinone (6PPDQ). Despite their detection in urines of pregnant women, the placental transfer and developmental toxicity of 6PPD and 6PPDQ ...
Wenxin Hu (1633882), Mark J. Zylka (168894), Sydney P. Thomas (10836245), Pieter C. Dorrestein (224907), Haoqi Nina Zhao (10163619)   +4 more
core   +1 more source

Computational Studies of Rubber Ozonation Explain the Effectiveness of 6PPD as an Antidegradant and the Mechanism of Its Quinone Formation

The discovery that the commercial rubber antidegradant 6PPD reacts with ozone (O3) to produce a highly toxic quinone (6PPDQ) spurred a significant research effort into nontoxic alternatives. This work has been hampered by lack of a detailed understanding
Martin Head-Gordon (588951), Elliot Rossomme (11173282), William J. Orts (3874051), Colleen M. McMahan (2487325), William M. Hart-Cooper (1868785)   +4 more
core   +3 more sources

Abiotic transformation of radiolabelled 6-PPD and 6-PPDQ in water and in presence of nitrogen/air/ozone and light

Ecotoxicology and Environmental Safety
N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylendiamine (6-PPD) and one of its oxidation products, 6-PPD quinone (6-PPDQ) are environmental contaminants released from tire and road wear particles (TRWP).
Thorsten Reemtsma, Bettina Seiwert, Pete Yeomans, Rory Mumford, Sara Bennett   +4 more
doaj   +1 more source

Unraveling the fate of 6PPD-Q in aquatic environment: Insights into formation, dissipation, and transformation under natural conditions

Environment International
The widespread occurrence of N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q) in aquatic environments and its hazards to aquatic species underscore the necessity of comprehending its environmental fate.
Xiaopeng Yan, Jin Xiao, Claude Kiki, Yuanyuan Zhang, Habasi Patrick Manzi, Guangpu Zhao, ShengDa Wang, Qian Sun   +7 more
doaj   +1 more source

Molecular Mechanisms of 6PPD and 6PPD-Q Toxicity in Neurodegenerative Diseases: A Network Toxicology and Experimental Validation Study

Toxics
6PPD is a widely used tire antioxidant that readily transforms into its more toxic ozonation product, 6PPD-quinone (6PPD-Q). Both compounds are emerging environmental contaminants with potential neurotoxic risks, yet their molecular mechanisms in ...
Ze Li, Yuyang Luo, Siyi Wang, Dingming Xue, Yixuan Zhang   +4 more
doaj   +1 more source

Pilotstudie av analys av 6PPD och 6PPD-quinone i avloppsvatten [Elektronisk resurs]

, 2023
Pilotstudie av analys av däckadditivet 6PPD och dess omvandlingsprodukt 6PPD-quinone (6PPDQ) i utgående vatten från de nio reningsverk som ingår i den årliga miljöövervakningen i avloppsreningsverk samt dagvattenprover före/efter rening vid två ...
Haglund, Peter,
core  

N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q) induces osteoporosis by a mechanism involving CX43-mediated mitochondrial autophagy dysfunction in bone marrow mesenchymal stem cells

Ecotoxicology and Environmental Safety
As an emerging environmental contaminant, N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q) poses a potential threat to public health. However, the potential link between 6PPD-Q exposure and bone health remains largely unexplored.
Haitao Zhang, Chaofeng Chen, Dayu Wang, Yiwei Huang, Yang Liu, Zhiyuan Wang, Furui Fu, Hongyu Wang, Senjie Shi, Yijin Li, Jianchun Zeng, Caiping Shen, Chudan Zhong, Xiaozhou Liu, Jinlun Chen, Jie Li, Shufen Liu, Jin Huang, Yirong Zeng, Wenjun Feng   +19 more
doaj   +1 more source

Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids

Biochemistry and Biophysics Reports
The tire rubber antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPD-Q) were recently found in human bodies.
Daniel J. Yeisley, Lijun Ren, Katy S. Papineau, Laura K. Schnackenberg, Gonçalo Gamboa da Costa, Tucker A. Patterson, Suzanne C. Fitzpatrick, Qiang Shi   +7 more
doaj   +1 more source

2H-SIAM Reveals Transformation Products of 6PPD-Quinone in Water-Level Fluctuation Zone Soils

The aims of this data is to identify potential TPs of 6PPDQ in the water-level fluctuation zones (WLFZs) by 2H-labeled 6PPDQ and 2H-SIAM pipeline. The bulk soil from WLFZ was collected after removal of surface debris from a depth of 0-20 cm on a campus ...
Chen, Ke
core   +1 more source