Results 61 to 70 of about 216 (131)

Competing aqueous transformation pathways of 6PPD: Kinetic and DFT insights into the negligible formation of 6PPDQ and dominance of 4-HDPA

Environmental Engineering Research
The tire antioxidant 6PPD transforms into the toxic 6PPD-quinone (6PPDQ, e.g., LC50 < 1 μg/L for sensitive aquatic species) via ozonation. However, its fate in ozone-free aqueous systems remains poorly understood. This study systematically deconvolutes the kinetics of 6PPD transformation into 6PPDQ and 4-hydroxydiphenylamine (4-HDPA) under various ...
Jungmin Kim, Yeong-Jin Kim, Sujin Bae, Dong-Hee Lim, Thillai Govindaraja Senthamaraikannan, Yu Sik Hwang   +5 more
openaire   +1 more source

Integrated Experimental and Software Methods for Non-Targeted Analyses Investigation of Vehicle-Derived Chemicals and Their Transformation Products

, 2023
Thesis (Ph.D.)--University of Washington, 2023Water pollution is a significant environmental issue that can yield detrimental impacts on human health and ecosystem. Compounding the basic environmental pollution problem is the fact that many chemicals can
Hu, Ximin
core  

Investigation of Key Molecular Mechanisms of 6PPDQ in Breast Cancer Development and Progression through Network Toxicology and Computational Simulation

Abstract Background The rapid expansion of tire manufacturing has led to widespread environmental contamination by 6PPD-quinone (6PPDQ). Although 6PPDQ exhibits well-documented toxicological properties, its mechanistic links to breast cancer pathogenesis remain unexplored.
Haili Lu, Xi Li, Jing Han, Hong Quan
openaire   +1 more source

Urine Excretion, Organ Distribution, and Placental Transfer of 6PPD and 6PPD-Quinone in Mice and Potential Developmental Toxicity through Nuclear Receptor Pathways. [PDF]

Environ Sci Technol, 2023
Zhao HN, Thomas SP, Zylka MJ, Dorrestein PC, Hu W.   +4 more
europepmc   +1 more source

EVALUATION OF THE RELATIVE ACUTE TOXICITY OF PPD ANTIOZONANT CHEMICALS AND THEIR TRANSFORMATION PRODUCTS ON COHO SALMON (ONCORHYNCHUS KISUTCH) [PDF]

6PPD, a critical component of automobile tires, reacts with ozone in the environment to prevent rubber from cracking. The identification of 6PPD-quinone (6PPDQ), a transformation product of 6PPD, as the probable causal toxicant of pre-spawn mortality ...
Lawrence, Caitlin
core   +1 more source

Evaluating the Carcinogenic Potential and Molecular Mechanisms of 6PPDQ in the Human Stomach Using Organoids and Bulk Sequencing Data: A Multi-Machine Learning Approach Combined with Computational Simulation

Abstract Background: The environmental contaminant 6PPD-quinone (6PPDQ), a tire rubber antioxidant derivative, has emerged as a potential health hazard, yet its association with gastric cancer (GC) remains unexplored.
Ke Yan, Cheng Li, Jia Ma, Yujie Liu, Xulong Zhu, Youfu Tian, Jianfei Zhang   +6 more
openaire   +1 more source

Dataset to accompany the manuscript titled 'First assessment of the ecotoxicological effects of the tire antioxidant 6PPD on early life stages of the popular sport fish species, the largemouth bass (Micropterus nigricans)'

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) is a widely used rubber antioxidant, entering aquatic ecosystems through roadway runoff of tire wear particles.
Winn, Louise M., Orihel, Diane M., Brinkmann, Markus, Seabrook, Katryna J., Canete, Ashley, Adams, Julie E., Xie, Linna, Peng, Hui, Robinson, Stacey A.   +8 more
core   +1 more source

Is recycling sustainable: The promise and risks of scrap tire valorization. [PDF]

iScience
Vahdatbin M, Hajikarimi P, Rashid S, Fini EH.   +3 more
europepmc   +1 more source

Rubber Dams: An Overlooked Source of Leachable Organic Contaminants within Water Infrastructure Systems

Inflatable rubber dams are used globally within water infrastructure, yet their potential as chemical contaminant sources remains overlooked. We investigated the occurrence of rubber additives and their transformation products within rubber dam materials
Yafen Ge, Melissa Gonzalez, Jeffrey Perala-Dewey, Emily K. Everton, Wei Wang, Edward P. Kolodziej   +5 more
core   +1 more source

Roadway Runoff Induced Acute Mortality in Juvenile Coho Salmon During Spring Storm Events. [PDF]

Environ Sci Technol
Brown ML, Ivy N, Gonzalez M, Greer JB, Hansen JD, Kolodziej E, McIntyre JK.   +6 more
europepmc   +1 more source