Results 81 to 90 of about 920 (179)

Acute Toxicity Testing of Pink Salmon (Oncorhynchus gorbuscha) with the Tire Rubber–Derived Chemical 6PPD-Quinone [PDF]

N‐(1,3‐dimethylbutyl)‐N′‐phenyl‐p‐phenylenediamine‐quinone (6PPD‐quinone) is a widespread contaminant of emerging concern resulting from oxidation of 6PPD, which is an antidegradant substance added to tires.
Sandodden, Roar, Ulvan, Eva Marita, Foldvik, Anders, Kryuchkov, Fedor, Kvingedal, Eli   +4 more
core   +1 more source

Phytotoxic effects of 6PPD on wheat: Insights into germination inhibition, oxidative stress, and metabolic disruptions

Environmental Chemistry and Ecotoxicology
N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), a widely used antioxidant in the rubber industry, has been identified as a pervasive environmental contaminant with significant ecological risks. However, its effects on terrestrial plants remain
Abdul Mateen Baig, Weitao Liu, Aurang Zeb, Hifza Iqbal, Sheharyar Khan, Ruiying Shi, Hamra Tariq, Jinzheng Liu, Yuexing Zhao, Xiang Li, Yichen Ge   +10 more
doaj   +1 more source

Exploring the mechanism of 6PPD/6PPD-Q-induced allergic rhinitis based on network toxicology, molecular docking, and molecular dynamic simulation

N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its ozonated derivative, 6PPD-quinone (6PPD-Q), are tire-derived contaminants with established aquatic toxicity, yet their role in respiratory allergies like Allergic Rhinitis (AR) remains ...
Wei Xia, Nan Shi, Anzhou Tang, Xuesong Wang, Jingyu Li, Xia Zhu   +5 more
core   +1 more source

Association between 6PPD-quinone exposure and BMI, influenza, and diarrhea in children [PDF]

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPD-quinone) has received extensive attention due to its ubiquitous distribution and potential toxicity. However, the distribution characteristics of 6PPD-quinone in dust from e-waste recycling
Zhang, Zhuxia, Wang, Qihua, Snieder, Harold; id_orcid, Zhong, Qi, Hylkema, Machteld N, Qian, Ziyi, Huo, Xia, Xu, Xijin   +7 more
core   +1 more source

Uptake of tire-wear derived compounds by lettuce grown in three soils

Environment International
Tire-wear derived compounds have recently been detected in commercially grown leafy vegetables, raising concern about their uptake and accumulation in crops under realistic agricultural conditions.
Anya Sherman, Luzian Elijah Hämmerle, Evyatar Ben Mordechay, Benny Chefetz, Thilo Hofmann   +4 more
doaj   +1 more source

N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q) induces osteoporosis by a mechanism involving CX43-mediated mitochondrial autophagy dysfunction in bone marrow mesenchymal stem cells

Ecotoxicology and Environmental Safety
As an emerging environmental contaminant, N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q) poses a potential threat to public health. However, the potential link between 6PPD-Q exposure and bone health remains largely unexplored.
Haitao Zhang, Chaofeng Chen, Dayu Wang, Yiwei Huang, Yang Liu, Zhiyuan Wang, Furui Fu, Hongyu Wang, Senjie Shi, Yijin Li, Jianchun Zeng, Caiping Shen, Chudan Zhong, Xiaozhou Liu, Jinlun Chen, Jie Li, Shufen Liu, Jin Huang, Yirong Zeng, Wenjun Feng   +19 more
doaj   +1 more source

Urine Excretion, Organ Distribution, and Placental Transfer of 6PPD and 6PPD-Quinone in Mice and Potential Developmental Toxicity through Nuclear Receptor Pathways

The rubber antioxidant 6PPD has gained significant attention due to its highly toxic transformation product, 6PPD-quinone (6PPDQ). Despite their detection in urines of pregnant women, the placental transfer and developmental toxicity of 6PPD and 6PPDQ ...
Wenxin Hu (1633882), Mark J. Zylka (168894), Sydney P. Thomas (10836245), Pieter C. Dorrestein (224907), Haoqi Nina Zhao (10163619)   +4 more
core   +1 more source

Integrated machine learning and experimental validation reveal S6K2 as a key target of 6PPD-quinone in bladder cancer

Ecotoxicology and Environmental Safety
Tire and Road Wear Particles (TRWP) are pervasive environmental contaminants, yet the molecular mechanisms linking their toxic derivative, 6PPD-quinone (6PPD-Q), to bladder cancer (BLCA) progression remain obscure.
Jirong Wang, Meng Lu, Nienie Qi, Meng Zhang, Zixiang Li, Hailong Li, Junqi Wang   +6 more
doaj   +1 more source

Environmental behavior and the degradation of tire-rubber-related pollutant 6PPD-quinone in soils

Applied Biological Chemistry
N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q), a transformation product of the tire rubber antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine, has recently been identified as a contaminant of emerging concern due to its ...
Min-Young Kim, Ji-Young An, Deuk-Yeong Lee, Seong-Hoon Jeong, Jong-Hwan Kim   +4 more
doaj   +1 more source

Development of a quantitative analytical method for 6PPD, a harmful tire antioxidant, in biological samples for toxicity assessment

Ecotoxicology and Environmental Safety
This study developed and validated a high-sensitivity analytical method for the quantification of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), a hazardous antioxidant used in tires, to support the effective management of its environmental ...
Min-Seok Choi, Sung-Hwan Kim, Moonjung Hyun, Sung Min Han, Yong-Hyun Kim   +4 more
doaj   +1 more source