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Free Radical Research, 2022
CD36 is the key scavenger receptor driving the formation of cholesterol-loaded foam cells, the principal cellular component of atherosclerotic plaques. CD36 is down regulated by 7,8-dihydroneopterin, a potent superoxide and hypochlorite scavenging antioxidant generated by interferon-γ stimulated macrophages. 7,8-dihydroneopterin downregulates CD36 mRNA
Barry Hock, Steven Gieseg
exaly +3 more sources
CD36 is the key scavenger receptor driving the formation of cholesterol-loaded foam cells, the principal cellular component of atherosclerotic plaques. CD36 is down regulated by 7,8-dihydroneopterin, a potent superoxide and hypochlorite scavenging antioxidant generated by interferon-γ stimulated macrophages. 7,8-dihydroneopterin downregulates CD36 mRNA
Barry Hock, Steven Gieseg
exaly +3 more sources
Mechanisms of 7,8-dihydroneopterin protection of macrophages from cytotoxicity [PDF]
, 2013 Gamma-interferon stimulates human macrophages to produce of 7,8-dihydroneopterin (7,8-NP). 7,8-NP and its oxidation product neopterin are excellent inflammatory markers for a variety of chronic conditions, including atherosclerosis. The biological significance of 7,8-NP in atherosclerosis is not fully understood, but 7,8-NP has been shown to protect ...
Shchepetkina, Anastasia
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7,8-Dihydroneopterin and its effect on the formation of foam cells. [PDF]
, 2015 Atherosclerosis (Heart Disease) is an inflammatory disease caused by the formation of plaque within the arterial wall. In response to inflammation, monocytes enter the artery wall, differentiate into macrophages and take up altered low-density-lipoprotein (such as oxidised-LDL). This oxLDL is taken up into the phagocytotic macrophages via the action of
Davies, Sian Patricia Mary
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Regulation of the CD36 scavenger receptor by the antioxidant 7,8-dihydroneopterin. [PDF]
, 2017 OxLDL uptake via the CD36 scavenger receptor leads to foam cell formation and is at the core of the development of atherosclerosis. One potential protective mechanism against this process involves the human macrophage derived anti-oxidant 7,8-dihydroneopterin (7,8-NP) down regulating CD36.
Yeandle, Anthony
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Mechanism of 7,8-dihydroneopterin to downregulate CD36 scavenger receptor and foam cell formation. [PDF]
, 2019 Atherosclerosis is a disorder that involves the build-up of plaque in medium and large arteries. Atherosclerotic plaques are made from a range of cellular and extracellular components including lipid-filled immune cells, smooth muscle cells (SMC), T-cells and fibroblasts.
Ghodsian, Nooshin
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Clinical Biochemistry, 2019
Knee arthroplasty surgery is significant trauma, leading to an activated immune system causing inflammation and oxidative stress. Many current biomarkers are invasive, costly, and often slow to analyse, limiting their use for rapid inflammatory measurements.We have examined the use of urinary neopterin and total neopterin in knee arthroplasty patients ...
Gary Hooper +2 more
exaly +3 more sources
Knee arthroplasty surgery is significant trauma, leading to an activated immune system causing inflammation and oxidative stress. Many current biomarkers are invasive, costly, and often slow to analyse, limiting their use for rapid inflammatory measurements.We have examined the use of urinary neopterin and total neopterin in knee arthroplasty patients ...
Gary Hooper +2 more
exaly +3 more sources
Free Radical Research, 2002
Low density lipoprotein (LDL) oxidation within the artery wall likely represents a key event in the formation of atherosclerotic lesions. Oxidatively modified LDL particles exert chemotactic properties on macrophages, and the uncontrolled uptake of modified LDL by macrophages leads to the formation of lipid-loaded foam cells, a hallmark of early stage ...
Joachim Greilberger +2 more
exaly +3 more sources
Low density lipoprotein (LDL) oxidation within the artery wall likely represents a key event in the formation of atherosclerotic lesions. Oxidatively modified LDL particles exert chemotactic properties on macrophages, and the uncontrolled uptake of modified LDL by macrophages leads to the formation of lipid-loaded foam cells, a hallmark of early stage ...
Joachim Greilberger +2 more
exaly +3 more sources
7,8-Dihydroneopterin-mediated protection of low density lipoprotein, but not human macrophages, from oxidative stress [PDF]
, 2006 Any lipoproteins and cells present in the inflammatory environment of atherosclerotic plaques are likely to be exposed to high levels of oxidative stress. As 7,8-dihydroneopterin (7,8-NP) is synthesized by interferon-γ (IFN-γ)-activated macrophages, this pteridine is also thought to exist at sites of inflammation.
Firth, Carole Anne
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7,8-dihydroneopterin inhibition of oxidised low density lipoprotein-induced cellular death [PDF]
, 2003 The death of monocyte and macrophage cells in the atherosclerotic plaque is thought to be due principally to the toxicity of oxidised LDL (oxLDL). This makes an important contribution to the development of the lipid core of advanced plaque and also to the overall stability of the plaque.
Baird, Sarah
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Formation of Oxygen Radicals in Solutions of 7,8-Dihydroneopterin
Biochemical and Biophysical Research Communications, 1999Neopterin and 7,8-dihydroneopterin, two compounds which are secreted by activated macrophages, have been shown to interfere with radicals generated by cellular and certain chemical systems. Reduced pterins were reported to scavenge whereas aromatic pterins promoted or reduced radical mediated reactions or had no effect.
K, Oettl +5 more
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