Study of the early metabolic characteristics in patients undergoing sleeve gastrectomy for the treatment of obesity and type 2 diabetes mellitus (T2DM) using high-performance liquid chromatography combined with high-resolution mass spectrometry via metabolomics technology. [PDF]
Arch Endocrinol MetabLu J +8 more
europepmc +1 more source
Nature Counts to Three: Universal Mg-Pinch Motif Polarizes the Cleaved Bond in NTP-Processing Enzymes. [PDF]
J Am Chem SocDudas B +9 more
europepmc +1 more source
A Systematic Review of Folate and the Human Enteric Microbiome: Biological Mechanisms and Clinical Implications. [PDF]
Int J Mol SciKhanduja R, Frye RE.
europepmc +1 more source
The Radical SAM Enzyme BlsE Can Operate as a Dehydratase, Dehydrogenase, or Epimerase upon Mutation of a Single Active Site Serine Residue. [PDF]
J Am Chem SocLee YH +6 more
europepmc +1 more source
Free Radical Biology and Medicine, 2020 Clinical measurement of neopterin has been extensively used as a marker of inflammation but the in vivo mechanism generating neopterin is poorly understood. Neopterin is described as the oxidation product of 7,8-dihydroneopterin, a potent antioxidant generated by monocyte/macrophages in response to interferon-γ.
Barry Hock, Steven Gieseg
exaly +5 more sources
Generation of carbon monoxide and iron from hemeproteins in the presence of 7,8-dihydroneopterin
Biochimica Et Biophysica Acta - General Subjects, 2002 7,8-Dihydroneopterin and neopterin are secreted by human and primate macrophages after activation by interferon-gamma in a ratio of 2:1. 7,8-Dihydroneopterin is known to suppress radical-mediated processes, but it is also able in the presence of iron ions to generate superoxide radical anion and hydroxyl radicals from molecular oxygen.
Gilbert Reibnegger, Christiane Jung
exaly +4 more sources
Synthesis of enzymatically active D-7,8-dihydroneopterin-3′-triphosphate
Biochemical and Biophysical Research Communications, 1988 The first chemical synthesis of D-neopterin-3'-triphosphate and D-7,8-dihydroneopterin-3'-triphosphate is described. D-neopterin-3'-monophosphate was first 1'-2'-0-formylated with anhydrous formic acid, then activated with 1,1'-carbonyldiimidazole and phosphorylated with n-tributyl-ammonium pyrophosphate. The yield of 3'-NTP was 24%.
Zagalak B +4 more
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Formation, Transport and Detection of 7,8-Dihydroneopterin [PDF]
, 2013 Atherosclerosis is a chronic inflammatory disease leading to plaque buildup in the major arteries. The plaques consist of cholesterol, calcium, inflammatory cells, extracellular matrix and fibrous material. Under inflammatory conditions IFN-• stimulation of human monocytes and macrophages generates reduced pteridine, 7,8-dihydroneopterin (78NP) which ...
Janmale, Tejraj Vijaykumar
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Modulation of LDL Oxidation by 7,8-Dihydroneopterin
Free Radical Research, 2004Human macrophages stimulated with interferon-gamma generate neopterin and 7,8-dihydroneopterin which interfere with reactive species involved in LDL oxidation. While neopterin was found to have pro-oxidative effects on copper-mediated LDL oxidation, the influence of 7,8-dihydroneopterin is more complex. This study provides detailed information that 7,8-
Joachim Greilberger +2 more
exaly +3 more sources
Free Radical Research, 2020 7,8-Dihydroneopterin protects cells intracellularly from oxidative stress-induced death, but its mode of transport across the cell membrane is unknown. Nucleosides, such as guanosine, are transported via nucleoside transporters of the equilibrative and concentrative forms.
Tejraj V. Janmale +2 more
openaire +3 more sources