Results 121 to 130 of about 808 (137)
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Free Radical Research, 2001
Interferon-gamma stimulation of human macrophages causes the synthesis and release of neopterin and its reduced form 7,8-dihydroneopterin (7,8-NP). The purpose of this cellular response is undetermined but in vitro experiments suggests 7,8-NP is an antioxidant. We have found 7,8-NP can protect monocyte-like U937 cells from oxidative damage.
Gieseg, S. P. +3 more
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Interferon-gamma stimulation of human macrophages causes the synthesis and release of neopterin and its reduced form 7,8-dihydroneopterin (7,8-NP). The purpose of this cellular response is undetermined but in vitro experiments suggests 7,8-NP is an antioxidant. We have found 7,8-NP can protect monocyte-like U937 cells from oxidative damage.
Gieseg, S. P. +3 more
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Mechanisms of 7,8-dihydroneopterin protection of macrophages from cytotoxicity
2013Gamma-interferon stimulates human macrophages to produce of 7,8-dihydroneopterin (7,8-NP). 7,8-NP and its oxidation product neopterin are excellent inflammatory markers for a variety of chronic conditions, including atherosclerosis. The biological significance of 7,8-NP in atherosclerosis is not fully understood, but 7,8-NP has been shown to protect ...
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Regulation of the CD36 scavenger receptor by the antioxidant 7,8-dihydroneopterin.
2017OxLDL uptake via the CD36 scavenger receptor leads to foam cell formation and is at the core of the development of atherosclerosis. One potential protective mechanism against this process involves the human macrophage derived anti-oxidant 7,8-dihydroneopterin (7,8-NP) down regulating CD36.
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7,8-Dihydroneopterin and its effect on the formation of foam cells.
2015Atherosclerosis (Heart Disease) is an inflammatory disease caused by the formation of plaque within the arterial wall. In response to inflammation, monocytes enter the artery wall, differentiate into macrophages and take up altered low-density-lipoprotein (such as oxidised-LDL). This oxLDL is taken up into the phagocytotic macrophages via the action of
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Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 1996
Human immunodeficiency virus (HIV) infection is associated with increased concentrations of neopterin derivatives, released in large quantities by human macrophages on stimulation with interferon-gamma (INF-gamma). Neopterin concentrations thus inversely correlate with absolute CD4+ T-cell numbers and strongly predict progression of disease from ...
G, Baier-Bitterlich +2 more
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Human immunodeficiency virus (HIV) infection is associated with increased concentrations of neopterin derivatives, released in large quantities by human macrophages on stimulation with interferon-gamma (INF-gamma). Neopterin concentrations thus inversely correlate with absolute CD4+ T-cell numbers and strongly predict progression of disease from ...
G, Baier-Bitterlich +2 more
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Mechanism of 7,8-dihydroneopterin to downregulate CD36 scavenger receptor and foam cell formation.
2019Atherosclerosis is a disorder that involves the build-up of plaque in medium and large arteries. Atherosclerotic plaques are made from a range of cellular and extracellular components including lipid-filled immune cells, smooth muscle cells (SMC), T-cells and fibroblasts.
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7,8-dihydroneopterin inhibition of oxidised low density lipoprotein-induced cellular death
2003The death of monocyte and macrophage cells in the atherosclerotic plaque is thought to be due principally to the toxicity of oxidised LDL (oxLDL). This makes an important contribution to the development of the lipid core of advanced plaque and also to the overall stability of the plaque.
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Role of 7,8-dihydroneopterin in T-cell apoptosis and HTLV-1 transcription in vitro.
Oncogene, 1997Adult T-cell leukemia is associated with high levels of neopterin, released in large amounts from human macrophages upon stimulation with interferon-gamma. Recent data suggested a potential role of neopterin-derivatives in oxygen radical-mediated processes, and evidence accumulates that oxidative stress is involved in the pathogenesis of viral diseases.
G, Baier-Bitterlich +7 more
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2006
Any lipoproteins and cells present in the inflammatory environment of atherosclerotic plaques are likely to be exposed to high levels of oxidative stress. As 7,8-dihydroneopterin (7,8-NP) is synthesized by interferon-γ (IFN-γ)-activated macrophages, this pteridine is also thought to exist at sites of inflammation.
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Any lipoproteins and cells present in the inflammatory environment of atherosclerotic plaques are likely to be exposed to high levels of oxidative stress. As 7,8-dihydroneopterin (7,8-NP) is synthesized by interferon-γ (IFN-γ)-activated macrophages, this pteridine is also thought to exist at sites of inflammation.
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