Results 101 to 110 of about 808 (137)
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Free Radical Research, 2022
CD36 is the key scavenger receptor driving the formation of cholesterol-loaded foam cells, the principal cellular component of atherosclerotic plaques. CD36 is down regulated by 7,8-dihydroneopterin, a potent superoxide and hypochlorite scavenging antioxidant generated by interferon-γ stimulated macrophages. 7,8-dihydroneopterin downregulates CD36 mRNA
Barry Hock, Steven Gieseg
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CD36 is the key scavenger receptor driving the formation of cholesterol-loaded foam cells, the principal cellular component of atherosclerotic plaques. CD36 is down regulated by 7,8-dihydroneopterin, a potent superoxide and hypochlorite scavenging antioxidant generated by interferon-γ stimulated macrophages. 7,8-dihydroneopterin downregulates CD36 mRNA
Barry Hock, Steven Gieseg
exaly +3 more sources
Protection of erythrocytes by the macrophage synthesized antioxidant 7,8 dihydroneopterin
Free Radical Research, 2001Neopterin and the reduced form, 7,8-dihydroneopterin (78NP) are pteridines released from macrophages when stimulated with gamma-interferon in vivo. The role of 78NP in inflammatory response is unknown though neopterin has been used clinically as a marker of immune cell activation, due to its very fluorescent nature.
Gieseg, S. P., Maghzal, G., Glubb, D.
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Generation of Carbon Monoxide and Iron From Hemeproteins in the Presence of 7,8-Dihydroneopterin
Biochimica Et Biophysica Acta - General Subjects, 20027,8-Dihydroneopterin and neopterin are secreted by human and primate macrophages after activation by interferon-gamma in a ratio of 2:1. 7,8-Dihydroneopterin is known to suppress radical-mediated processes, but it is also able in the presence of iron ions to generate superoxide radical anion and hydroxyl radicals from molecular oxygen.
Gilbert Reibnegger +2 more
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Oxidation of 7,8-Dihydroneopterin by Hypochlorous Acid Yields Neopterin
Biochemical and Biophysical Research Communications, 2000In vitro, interferon-gamma stimulates primate monocytes/macrophages to produce the pteridines neopterin and 7,8-dihydroneopterin. These pteridines are capable of modulating the oxidative potential of reactive species. Neopterin is pro-oxidative whereas 7, 8-dihydroneopterin is an effective antioxidant. In the presence of oxygen, 7,8-dihydroneopterin is
B, Widner +3 more
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Synthesis of enzymatically active D-7,8-dihydroneopterin-3′-triphosphate
Biochemical and Biophysical Research Communications, 1988The first chemical synthesis of D-neopterin-3'-triphosphate and D-7,8-dihydroneopterin-3'-triphosphate is described. D-neopterin-3'-monophosphate was first 1'-2'-0-formylated with anhydrous formic acid, then activated with 1,1'-carbonyldiimidazole and phosphorylated with n-tributyl-ammonium pyrophosphate. The yield of 3'-NTP was 24%.
Zagalak B +4 more
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Photodimerization of 7,8‐Dihydroneopterin in Aqueous Solution Under UV‐A Irradiation
Photochemistry and Photobiology, 2010Abstract7,8‐Dihydroneopterin (H2Nep) is secreted during the oxidative burst of stimulated macrophages. The photochemistry of H2Nep was investigated in neutral aqueous solutions exposed to UV‐A radiation (320–400 nm) at room temperature. The kinetics were followed by UV/Vis spectrophotometry and HPLC, whereas the photoproducts were analyzed by ...
Mariana, Vignoni +3 more
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Free Radical Research, 2020
7,8-Dihydroneopterin protects cells intracellularly from oxidative stress-induced death, but its mode of transport across the cell membrane is unknown. Nucleosides, such as guanosine, are transported via nucleoside transporters of the equilibrative and concentrative forms.
Tejraj V. Janmale +2 more
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7,8-Dihydroneopterin protects cells intracellularly from oxidative stress-induced death, but its mode of transport across the cell membrane is unknown. Nucleosides, such as guanosine, are transported via nucleoside transporters of the equilibrative and concentrative forms.
Tejraj V. Janmale +2 more
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Spin Trapping Study of Antioxidant Properties of Neopterin and 7,8-Dihydroneopterin
Biochemical and Biophysical Research Communications, 1997Previously, it has been shown that pteridine derivatives are capable of modulating the action of free radicals and both prooxidant and antioxidant properties have been described. However, the mechanism of manifestation of these properties is still unclear. We studied the radical scavenging properties of 7,8-dihydroneopterin and neopterin using the spin
K, Oettl +4 more
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7,8-Dihydroneopterin Induces Apoptosis of Jurkat T-Lymphocytes via a Bcl-2-Sensitive Pathway
European Journal of Cell Biology, 2002 Activated cell-mediated immunity is known to be accompanied by elevated concentrations of 7,8-dihydroneopterin which in high concentrations was found to interfere with the oxidant-antioxidant balance. In this study we investigated whether 7,8-dihydroneopterin mediates apoptosis of Jurkat T-lymphocytes via a CrmA- or Bcl-2-sensitive pathway.
Gottfried Baier +2 more
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Free Radical Research, 2002
Low density lipoprotein (LDL) oxidation within the artery wall likely represents a key event in the formation of atherosclerotic lesions. Oxidatively modified LDL particles exert chemotactic properties on macrophages, and the uncontrolled uptake of modified LDL by macrophages leads to the formation of lipid-loaded foam cells, a hallmark of early stage ...
Joachim Greilberger +2 more
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Low density lipoprotein (LDL) oxidation within the artery wall likely represents a key event in the formation of atherosclerotic lesions. Oxidatively modified LDL particles exert chemotactic properties on macrophages, and the uncontrolled uptake of modified LDL by macrophages leads to the formation of lipid-loaded foam cells, a hallmark of early stage ...
Joachim Greilberger +2 more
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