Results 111 to 120 of about 808 (137)
Some of the next articles are maybe not open access.
Effects of neopterin and 7,8‐dihydroneopterin on hypoxia‐induced renal erythropoietin production
European Journal of Haematology, 1999Abstract: Activation of the human cellular immune system is associated with greatly increased formation of the pteridines neopterin and 7,8‐dihydroneopterin. It has been postulated that pteridines play a role in the pathogenesis of the anaemia of inflammation.
H, Pagel +4 more
openaire +2 more sources
Dissociation of neopterin and 7,8-dihydroneopterin from plasma components before HPLC analysis
Journal of Chromatography B, 2008Measurement of plasma neopterin by HPLC with fluorescence detection is used clinically as a marker of immune cell activation in the management of a number of disease pathologies. HPLC analysis of neopterin requires the acidic removal of plasma proteins but we have found that 7,8-dihydroneopterin is oxidised to neopterin with varying yield.
Elizabeth A, Flavall +3 more
openaire +2 more sources
The International Journal of Biochemistry & Cell Biology, 2021
Cluster of differentiation 36 (CD36) is a key scavenger receptor in the control of macrophage uptake of oxidised low-density lipoproteins (oxLDL). CD36 expression levels are not down regulated by intracellular cholesterol but are upregulated by oxidised low density lipoprotein (oxLDL) leading to the formation of lipid loaded foam cells, a major ...
Nooshin Ghodsian +2 more
openaire +2 more sources
Cluster of differentiation 36 (CD36) is a key scavenger receptor in the control of macrophage uptake of oxidised low-density lipoproteins (oxLDL). CD36 expression levels are not down regulated by intracellular cholesterol but are upregulated by oxidised low density lipoprotein (oxLDL) leading to the formation of lipid loaded foam cells, a major ...
Nooshin Ghodsian +2 more
openaire +2 more sources
Clinical Biochemistry, 2019
Knee arthroplasty surgery is significant trauma, leading to an activated immune system causing inflammation and oxidative stress. Many current biomarkers are invasive, costly, and often slow to analyse, limiting their use for rapid inflammatory measurements.We have examined the use of urinary neopterin and total neopterin in knee arthroplasty patients ...
Gary Hooper +2 more
exaly +3 more sources
Knee arthroplasty surgery is significant trauma, leading to an activated immune system causing inflammation and oxidative stress. Many current biomarkers are invasive, costly, and often slow to analyse, limiting their use for rapid inflammatory measurements.We have examined the use of urinary neopterin and total neopterin in knee arthroplasty patients ...
Gary Hooper +2 more
exaly +3 more sources
Medical Microbiology and Immunology, 2006
Pteridine derivatives neopterin and 7,8-dihydroneopterin are produced by human macrophages and dendritic cells upon stimulation with interferon-gamma (IFN-gamma) and therefore become detectable in increased amounts in humans during cell-mediated (Th1-type) immune response.
Olga, Bratslavska +4 more
openaire +2 more sources
Pteridine derivatives neopterin and 7,8-dihydroneopterin are produced by human macrophages and dendritic cells upon stimulation with interferon-gamma (IFN-gamma) and therefore become detectable in increased amounts in humans during cell-mediated (Th1-type) immune response.
Olga, Bratslavska +4 more
openaire +2 more sources
Formation, Transport and Detection of 7,8-Dihydroneopterin
2013Atherosclerosis is a chronic inflammatory disease leading to plaque buildup in the major arteries. The plaques consist of cholesterol, calcium, inflammatory cells, extracellular matrix and fibrous material. Under inflammatory conditions IFN-• stimulation of human monocytes and macrophages generates reduced pteridine, 7,8-dihydroneopterin (78NP) which ...
openaire +2 more sources
trans -Activation of the HIV Type 1 Promoter by 7,8-Dihydroneopterin in Vitro
AIDS Research and Human Retroviruses, 1997Infection with human immunodeficiency virus type 1 and 2 is associated with elevated concentrations of neopterin, released in large quantities by human macrophages on stimulation with interferon gamma. Evidence has suggested a potential role of neopterin derivatives in oxygen radical-mediated processes.
G, Baier-Bitterlich +8 more
openaire +2 more sources
Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from staphylococcus aureus
Nature Structural Biology, 1998Dihydroneopterin aldolase catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin during the de novo synthesis of folk acid from guanosine triphosphate. The gene encoding the dihydroneopterin aldolase from S. aureus has been cloned, sequenced and expressed in Escherichia coli.
Michael Hennig +5 more
openaire +1 more source
Neopterin and 7,8-Dihydroneopterin-Induced Signal Transduction Cascades in Cell Lines
2002Stimulation of monocytes/macrophages with IFN-g, derived from activated T cells, results in the release of elevated concentrations of neopterin and 7,8-dihydroneopterin by activation of GTP cyclohydrolase I (1,2). In patients, he production of neopterin hereby closely correlates with IFN-g concentrations and the activation of cell mediated immunity (3).
Christiane Enzinger +6 more
openaire +1 more source
Oral Diseases
AbstractObjectiveDetermine the saliva and serum levels of neopterin (NP) and 7,8‐dihydroneopterin (7,8NP) in periodontitis patients and to reveal the relationship of these data with clinical periodontal parameters.Materials and MethodsTwenty‐three patients with stage III/grade B periodontitis and 23 periodontally healthy individuals were included ...
Emrah Turkmen +8 more
openaire +2 more sources
AbstractObjectiveDetermine the saliva and serum levels of neopterin (NP) and 7,8‐dihydroneopterin (7,8NP) in periodontitis patients and to reveal the relationship of these data with clinical periodontal parameters.Materials and MethodsTwenty‐three patients with stage III/grade B periodontitis and 23 periodontally healthy individuals were included ...
Emrah Turkmen +8 more
openaire +2 more sources