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Formation and structure determination of 5,6-epoxy-8,11,14-eicosatrienoic acid and 5-oxo-8,11,14-z-eicosatrienoic acid

Tetrahedron Letters, 1983
Abstract The formation of 5,6-epoxy-8,11,14-z-eicosatrienoic acid and 5-oxo-8,11,14-z-eicosatrienoic acid as by-products in the synthesis of 5-hydroxy-6-E-8,11,14-z-eicosatetraenoic acid is described.
Bernd W Spur
exaly   +2 more sources

Novel Biological Transformations of 8,11,14-Eicosatrienoic Acid

Journal of the American Chemical Society, 1966
Mats Hamberg
exaly   +2 more sources

Utilization of dihomo-γ-linolenic acid (8,11,14-eicosatrienoic acid) by murine peritoneal macrophages

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988
This study examined the metabolism of dihomo-gamma-linolenic acid (20:3(n-6] in casein-elicited murine peritoneal macrophages. Cells were incubated with [14C]20:3(n-6) in the presence of 1% fetal bovine serum (FBS) or 0.025% bovine serum albumin (BSA), and the distribution and identity of membrane-bound and soluble products were determined. Approx.
R S, Chapkin   +3 more
openaire   +2 more sources

The total synthesis and characterization of six methyl branched isomers of 8,11,14-eicosatrienoic acid

Chemistry and Physics of Lipids, 1976
Abstract Six methyl branched isomers of 8,11,14-eicosatrienoic acid were prepared in which a methyl branch was located on carbons 5, 10, 13, 17, 18 and 19 ...
U H, Do, H, Sprecher
openaire   +2 more sources

Conversion of 8,11,14-eicosatrienoic acid to 11,12-epoxy-10-hydroxy-8-heptadecenoic acid by aorta

Prostaglandins, 1983
Particulate fractions from fetal calf aorta convert 8,11,14-eicosatrienoic acid to a number of products derived from 12-hydroperoxy-8,10-heptadecadienoic acid, including 2 stereoisomers of 11,12-epoxy-10-hydroxy-8-heptadecenoic acid (11,12e-10h-17:1), which were identified by mass spectrometry.
C D, Funk, W S, Powell
openaire   +2 more sources

The enzymic conversion of allcis 8,11,14‐eicosatrienoic acid into prostaglandin E1

Recueil des Travaux Chimiques des Pays-Bas, 1966
AbstractIn the biosynthesis of prostaglandin E1 (PGE1) with an enzyme fraction of sheep vesicular glands glutathione and a moderate amount of antioxidant are required to obtain maximum yield; two oxygen molecules are consumed per mole PGE1 formed. By altering the incubation conditions, besides PGE1 various other products can be obtained.A scheme for ...
D. H. Nugteren   +2 more
openaire   +1 more source

ChemInform Abstract: SYNTHESIS OF PROSTAGLANDIN SYNTHETASE SUBSTRATE ANALOGS. 2. (8Z,11Z,14Z)‐15‐METHYL‐8,11,14‐EICOSATRIENOIC ACID

Chemischer Informationsdienst, 1978
AbstractAus dem Alkin‐carbonsäureester (I) erhält man durch Addition von Lithiumdimethylkupfer das Olefin (II), das zum Carbinol (IIIa) reduziert und über das Bromid (IIIb) mit dem aus (IV) erhaltenen Alkadiinyl‐ chlorid (V) zu (VI) kondensiert wird.
M. I. DAWSON   +3 more
openaire   +1 more source

The effect of ticlopidine on the aggregation of rat blood platelets and on the formation of metabolites from arachidonic acid and 8,11,14-eicosatrienoic acid in rat platelets during aggregation, and in the rat kidney

Agents and Actions, 1982
The effect of ticlopidine after oral administration was determined on the aggregation of rat blood platelets and on the formation of cyclo-oxygenase, and lipoxygenase metabolites from arachidonic acid (AA) and 8,11,14-eicosatrienoic acid in rat platelets and in the kidney. 1. Platelet aggregation is inhibited by ticlopidine.
J E, Vincent   +3 more
openaire   +2 more sources

Correlations between surface area and the rate of enzymatic desaturation with methyl branched 8,11,14‐eicosatrienoic acid

Lipids, 1979
AbstractMethyl‐branched derivatives of methyl 8,11,14‐eicosatrienoate form stable liquid‐expanded monolayers. Surface areas are expanded by the methyl branch. The expansion effect is a function of surface pressure. At high surface pressure, the greatest expansion occurs with a mid‐point methyl branch.
G S, Patil, H, Sprecher, D G, Cornwell
openaire   +2 more sources

On the Incorporation of Oxygen in the Conversion of 8,11,14-Eicosatrienoic Acid to Prostaglandin E1

Journal of the American Chemical Society, 1965
Prostaglandin E1 was synthesized by incubating 81114-eicosatrienoic acid with a proportion of vesicular gland for 10 minutes in an atmosphere of labeled oxygen. To determine the origin of the oxygens of the ring a derivative was oxidized by permanganate-periodate and analyzed by mass spectrometry.
openaire   +2 more sources

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