Results 11 to 20 of about 1,760 (172)

Serotonin Receptors in Areas of the Emotion Regulation Network in Human and Rat Brains-A Comparative Autoradiographic Study. [PDF]

J Comp Neurol
Serotonin receptors in areas of the emotion regulation network in human and rat brains a comparative autoradiographic study. Our systematic comparative analysis revealed significant differences of 5‐HT1A and 5‐HT2 receptor distributions and of their balance within and across components of the human emotion regulation network and homolog areas in rats ...
Kuckertz A, Zhao L, Kedo O, Amunts K, PalomeroGallagher N.   +4 more
europepmc   +2 more sources

Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat. [PDF]

J Neurosci, 1996
In vivo microdialysis was used to analyze the role of dorsal raphe nucleus (DRN) neurons in regulating the sleep-waking cycle. Measurements of extracellular serotonin (5-HT) were made in the DRN of freely moving adult cats before and during microdialysis
Portas CM, Thakkar M, Rainnie D, McCarley RW.   +3 more
europepmc   +2 more sources

Research progress on intranasal treatment for Parkinson's disease. [PDF]

Neuroprotection
Intranasal treatment: A promising choice for Parkinson's disease (PD). Abstract Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder globally, significantly affecting the quality of life of affected individuals. Systemic drug delivery to the brain is inefficient because of first‐pass metabolism, the blood‐brain barrier (BBB),
Wen P, Ren C.
europepmc   +2 more sources

HTR1A Inhibits the Progression of Triple‐Negative Breast Cancer via TGF‐β Canonical and Noncanonical Pathways

Advanced Science, Volume 9, Issue 12, April 25, 2022., 2022
This study confirms that 5‐hydroxytryptamine receptor 1A significantly inhibits the development of triple‐negative breast cancer (TNBC) cells in vivo and in vitro via downregulating the TGF‐β canonical and noncanonical pathways, which is an independent prognostic factor for TNBC patients.
Qiqi Liu, Hefen Sun, Yang Liu, Xuan Li, Baojin Xu, Liangdong Li, Wei Jin   +6 more
wiley   +1 more source

The effect of 5‐HT1A receptor agonists on the entopeduncular nucleus is modified in 6‐hydroxydopamine‐lesioned rats

British Journal of Pharmacology, Volume 178, Issue 12, Page 2516-2532, June 2021., 2021
Background and Purpose l‐DOPA prolonged treatment leads to disabling motor complications as dyskinesia that could be decreased by drugs acting on 5‐HT1A receptors. Since the internal segment of the globus pallidus, homologous to the entopeduncular nucleus in rodents, seems to be involved in the etiopathology of l‐DOPA‐induced dyskinesia, we ...
Sergio Vegas‐Suárez, Asier Aristieta, Catalina Requejo, Harkaitz Bengoetxea, José Vicente Lafuente, Cristina Miguelez, Luisa Ugedo   +6 more
wiley   +1 more source

Microdosing ketamine in Drosophila does not block serotonin reuptake, but causes complex behavioral changes mediated by glutamate and serotonin receptors. [PDF]

J Neurochem
Microdosing ketamine is a novel depression treatment, but it is not clear how it changes serotonin. Drosophila melanogaster (fruit fly) is a good model to study depressive behaviors. We used fast‐scan cyclic voltammetry, video tracking, and feeding assays to measure serotonin and behavior after feeding ketamine and SSRIs to larvae.
Dunham KE, Khaled KH, Weizman L, Venton BJ.   +3 more
europepmc   +2 more sources

6‐Hydroxydopamine lesion and levodopa treatment modify the effect of buspirone in the substantia nigra pars reticulata

British Journal of Pharmacology, Volume 177, Issue 17, Page 3957-3974, September 2020., 2020
Background and Purpose l‐DOPA‐induced dyskinesia (LID) is considered a major complication in the treatment of Parkinson's disease (PD). Buspirone (5‐HT1A partial agonist) have shown promising results in the treatment of PD and LID, however no 5‐HT‐based treatment has been approved in PD.
Sergio Vegas‐Suárez, Clarissa Anna Pisanò, Catalina Requejo, Harkaitz Bengoetxea, Jose Vicente Lafuente, Michele Morari, Cristina Miguelez, Luisa Ugedo   +7 more
wiley   +1 more source

Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression [PDF]

, 2001
Individual differences in aggressive behaviour have been linked to variability in central serotonergic activity, both in humans and animals. A previous experiment in mice, selectively bred for high or low levels of aggression, showed an up-regulation of ...
Buwalda, Bauke, Vegt, Bea J. van der,, van der Vegt, BJ, Ruiter, Anne J.H. de,, Jong, Jelly G. de,, Koolhaas, J.M., de Ruiter, Anne J.H., Bauke Buwalda, Sietse F de Boer, Koolhaas, Jaap M.,, van der Vegt, Bea J., de Jong, Jelly G., Koolhaas, JM, de Boer, SF, de Jong, JG, Buwalda, Bauke,, Buwalda, B, Bea J van der Vegt, Boer, Sietse F. de,, Anne J.H de Ruiter, Jelly G de Jong, de Boer, Sietse F., Jaap M Koolhaas, de Ruiter, AJH   +23 more
core   +1 more source

The generation of immune‐induced fever and emotional stress‐induced hyperthermia in mice does not involve brown adipose tissue thermogenesis

The FASEB Journal, Volume 34, Issue 4, Page 5863-5876, April 2020., 2020
Abstract We examined the role of brown adipose tissue (BAT) for fever and emotional stress‐induced hyperthermia. Wild‐type and uncoupling protein‐1 (UCP‐1) knockout mice were injected with lipopolysaccharide intraperitoneally or intravenously, or subjected to cage exchange, and body temperature monitored by telemetry.
Anna Eskilsson, Kiseko Shionoya, Sven Enerbäck, David Engblom, Anders Blomqvist   +4 more
wiley   +1 more source

Allosteric modulation of G protein‐coupled receptors by amiloride and its derivatives. Perspectives for drug discovery?

Medicinal Research Reviews, Volume 40, Issue 2, Page 683-708, March 2020., 2020
Abstract The function of G protein‐coupled receptors (GPCRs) can be modulated by compounds that bind to other sites than the endogenous orthosteric binding site, so‐called allosteric sites. Structure elucidation of a number of GPCRs has revealed the presence of a sodium ion bound in a conserved allosteric site.
Arnault Massink, Tasia Amelia, Alex Karamychev, Adriaan P. IJzerman   +3 more
wiley   +1 more source