Results 21 to 30 of about 1,760 (172)

D2-Like Receptors Mediate the Expulsion Phase of Ejaculation Elicited by 8-Hydroxy-2-(di-N-propylamino)tetralin in Rats [PDF]

, 2020
The mechanism of action by which 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT) facilitates ejaculation in conscious rats is not clearly established.
Pierre Clé, Franç Ois Giuliano, Jacques Bernabé, Laurent Alexandre, Hosein Kami Kia   +4 more
core  

Intraspinal Grafting of Serotonergic Neurons Modifies Expression of Genes Important for Functional Recovery in Paraplegic Rats

Neural Plasticity, Volume 2018, Issue 1, 2018., 2018
Serotonin (5‐hydroxytryptamine; 5‐HT) plays an important role in control of locomotion, partly through direct effects on motoneurons. Spinal cord complete transection (SCI) results in changes in 5‐HT receptors on motoneurons that influence functional recovery.
Krzysztof Miazga, Hanna Fabczak, Ewa Joachimiak, Małgorzata Zawadzka, Łucja Krzemień-Ojak, Marek Bekisz, Anna Bejrowska, Larry M. Jordan, Urszula Sławińska, Junichi Ushiba   +9 more
wiley   +1 more source

CORRELATION BETWEEN THE SITES LABELED BY [H-3]-8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN AND [H-3]-IMIPRAMINE IN HUMAN PLATELETS

, 1995
The authors investigated the possible correlations between the binding parameters, maximum binding capacity (B-max) and dissociation constant (K-d), of [H-3]-8 hydroxy-2-(di-N-propylamino)tetralin and [H-3]-imipramine in platelets of 13 healthy subjects.
GIANNACCINI, GINO, MARTINI, CLAUDIA, CASTROGIOVANNI S, MARAZZITI D, ROSSI, ALESSANDRA, MICALI MG, CASSANO GB, LUCACCHINI, ANTONIO   +7 more
core   +1 more source

Age‐Dependent Switch of the Role of Serotonergic 5‐HT1A Receptors in Gating Long‐Term Potentiation in Rat Visual Cortex In Vivo

Neural Plasticity, Volume 2016, Issue 1, 2016., 2016
The rodent primary visual cortex (V1) is densely innervated by serotonergic axons and previous in vitro work has shown that serotonin (5‐HT) can modulate plasticity (e.g., long‐term potentiation (LTP)) at V1 synapses. However, little work has examined the effects of 5‐HT on LTP under in vivo conditions.
Peter J. Gagolewicz, Hans C. Dringenberg, Preston E. Garraghty   +2 more
wiley   +1 more source

The Effect of Long‐Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High‐Fat Diet/Low‐Dose Streptozotocin‐Induced Type 2 Diabetes

International Journal of Endocrinology, Volume 2015, Issue 1, 2015., 2015
In the last years the treatment of type 2 diabetes mellitus (DM2) was carried out using regulators of the brain signaling systems. In DM2 the level of the brain serotonin is reduced. So far, the effect of the increase of the brain serotonin level on DM2‐induced metabolic and hormonal abnormalities has been studied scarcely.
Kira V. Derkach, Vera M. Bondareva, Oxana V. Chistyakova, Lev M. Berstein, Alexander O. Shpakov, Ichiro Sakata   +5 more
wiley   +1 more source

Yokukansan Increases 5‐HT1A Receptors in the Prefrontal Cortex and Enhances 5‐HT1A Receptor Agonist‐Induced Behavioral Responses in Socially Isolated Mice

Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015
The traditional Japanese medicine yokukansan has an anxiolytic effect, which occurs after repeated administration. In this study, to investigate the underlying mechanisms, we examined the effects of repeated yokukansan administration on serotonin 1A (5‐HT1A) receptor density and affinity and its expression at both mRNA and protein levels in the ...
Toshiyuki Ueki, Kazushige Mizoguchi, Takuji Yamaguchi, Akinori Nishi, Yasushi Ikarashi, Tomohisa Hattori, Yoshio Kase, Helmut Hugel   +7 more
wiley   +1 more source

Oral Cavity Absorption of (R)−8−Hydroxy−2−(di-n-propylamino)tetralin and (S)−8−Acetyl−2−(di-n-propylamino)tetralin in the Rat

, 1996
The present communication reports on the efficacy of (R)−8−OH-DPAT ((R)−8−hydroxy−2−(di-n-propylamino)tetralin) and (S)-LY−41 ((S)−8−acetyl−2−(di-n-propylamino)tetralin) in displaying the 5−HT1A syndrome and decreasing body temperature after ...
Hong Yu, Ye Liu, Uli Hacksell, Tommy Lewander   +3 more
core   +1 more source

Updates on Antiobesity Effect of Garcinia Origin (−)‐HCA

Evidence-Based Complementary and Alternative Medicine, Volume 2013, Issue 1, 2013., 2013
Garcinia is a plant under the family of Clusiaceae that is commonly used as a flavouring agent. Various phytochemicals including flavonoids and organic acid have been identified in this plant. Among all types of organic acids, hydroxycitric acid or more specifically (−)‐hydroxycitric acid has been identified as a potential supplement for weight ...
Li Oon Chuah, Wan Yong Ho, Boon Kee Beh, Swee Keong Yeap, Vincenzo De Feo   +4 more
wiley   +1 more source

Efeitos ingestivos de injeções de 8-OH-DPATem distritos pontomesencefálicos que contêm pericários imunoreativos à serotonina em pombos (Columba livia) [PDF]

, 2001
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em NeurociênciasO presente trabalho descreve os efeitos de injeções locais de 8-OH-DPAT em vários distritos do tegmento ...
Häckl, Luciane Pereira Nascimento
core  

Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning‐Based Advanced Perspectives

Advanced Science, Volume 12, Issue 15, April 17, 2025.
Graphic illustration showing the strategic approaches based on the currently investigated evidence of psychedelics that suggests the challenges and how to address the prescription of mental disorders. These applicable avenues may provide substantial insight into distinguishing between brain networks and psychedelics.
Sung‐Hyun Kim, Sumin Yang, Jeehye Jung, Jeonghyeon Choi, Mingon Kang, Jae‐Yeol Joo   +5 more
wiley   +1 more source