Results 1 to 10 of about 1,352 (137)

Noise sensitivity of 89Zr-Immuno-PET radiomics based on count-reduced clinical images [PDF]

EJNMMI Physics, 2022
Purpose Low photon count in 89Zr-Immuno-PET results in images with a low signal-to-noise ratio (SNR). Since PET radiomics are sensitive to noise, this study focuses on the impact of noise on radiomic features from 89Zr-Immuno-PET clinical images.
Ananthi Somasundaram, David Vállez García, Elisabeth Pfaehler, Yvonne W. S. Jauw, Josée M. Zijlstra, Guus A. M. S. van Dongen, Willemien C. Menke-van der Houven van Oordt, Marc C. Huisman, Elisabeth G. E. de Vries, Ronald Boellaard   +9 more
doaj   +5 more sources

Optimal imaging time points considering accuracy and precision of Patlak linearization for 89Zr-immuno-PET: a simulation study [PDF]

EJNMMI Research, 2022
Purpose Zirconium-89-immuno-positron emission tomography (89Zr-immuno-PET) has enabled visualization of zirconium-89 labelled monoclonal antibody (89Zr-mAb) uptake in organs and tumors in vivo.
Jessica E. Wijngaarden, Marc C. Huisman, Johanna E. E. Pouw, C. Willemien Menke-van der Houven van Oordt, Yvonne W. S. Jauw, Ronald Boellaard   +5 more
doaj   +2 more sources

Potential and pitfalls of 89Zr-immuno-PET to assess target status: 89Zr-trastuzumab as an example [PDF]

EJNMMI Research, 2021
Background 89Zirconium-immuno-positron emission tomography (89Zr-immuno-PET) is used for assessment of target status to guide antibody-based therapy.
Marc C. Huisman, C. Willemien Menke-van der Houven van Oordt, Josée M. Zijlstra, Otto S. Hoekstra, Ronald Boellaard, Guus A. M. S. van Dongen, Dhaval K. Shah, Yvonne W. S. Jauw   +7 more
doaj   +2 more sources

[89Zr]-immuno-PET prediction of response to rituximab treatment in patients with therapy refractory interstitial pneumonitis: a phase 2 trial. [PDF]

Eur J Nucl Med Mol Imaging, 2023
Introduction: Immune-mediated interstitial pneumonitis may be treated with anti-CD20 therapy after failure of conventional therapies. However, clinical response is variable.
Adams H, van de Garde EMW, Vugts DJ, Grutters JC, Oyen WJG, Keijsers RG.   +5 more
europepmc   +6 more sources

Celecoxib-Induced Modulation of Colon Cancer CD133 Expression Occurs through AKT Inhibition and Is Monitored by 89Zr Immuno-PET [PDF]

Molecular Imaging, 2022
We developed an immuno-PET technique that monitors modulation of tumor CD133 expression, which is required for the success of CD133-targeted therapies. Methods. Anti-CD133 antibodies were subjected to sulfhydryl moiety-specific 89Zr conjugation.
Kyung-Ho Jung, Jin Hee Lee, Mina Kim, Eun Ji Lee, Young Seok Cho, Kyung-Han Lee   +5 more
doaj   +2 more sources

How to obtain the image-derived blood concentration from 89Zr-immuno-PET scans [PDF]

EJNMMI Physics
Background PET scans using zirconium-89 labelled monoclonal antibodies (89Zr-mAbs), known as 89Zr-immuno-PET, are made to measure uptake in tumour and organ tissue. Uptake is related to the supply of 89Zr-mAbs in the blood.
Jessica E. Wijngaarden, Amina Ahbari, Johanna E. E. Pouw, Henri N. J. M. Greuter, Idris Bahce, Gerben J. C. Zwezerijnen, Daniëlle J. Vugts, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt, Marc C. Huisman   +10 more
doaj   +2 more sources

89Zr Immuno-PET Imaging of Tumor PD-1 Reveals That PMA Upregulates Lymphoma PD-1 through NFκB and JNK Signaling [PDF]

Molecular Imaging, 2022
Immune therapy of T-cell lymphoma requires assessment of tumor-expressed programmed cell death protein-1 (PD-1). Herein, we developed an immuno-PET technique that quantitatively images and monitors regulation of PD-1 expression on T-cell lymphomas ...
Kyung-Ho Jung, Jin Hee Lee, Mina Kim, Young Seok Cho, Kyung-Han Lee   +4 more
doaj   +2 more sources

Non-specific irreversible 89Zr-mAb uptake in tumours: evidence from biopsy-proven target-negative tumours using 89Zr-immuno-PET [PDF]

EJNMMI Research
Background Distribution of mAbs into tumour tissue may occur via different processes contributing differently to the 89Zr-mAb uptake on PET. Target-specific binding in tumours is of main interest; however, non-specific irreversible uptake may also be ...
Jessica E. Wijngaarden, Yvonne W. S. Jauw, Gerben J. C. Zwezerijnen, Berlinda J. de Wit-van der Veen, Daniëlle J. Vugts, Josée M. Zijlstra, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt, Marc C. Huisman   +9 more
doaj   +2 more sources

A novel diagnosis strategy for chronic inflammatory bowel diseases using immuno-PET of [89Zr]Zr-IL-23p19 antibody [PDF]

Scientific Reports
Inflammatory bowel disease (IBD) is a chronic inflammatory condition requiring accurate and non-invasive imaging for diagnosis and monitoring. Current clinical methods, including Disease Activity Index (DAI) scoring, have limitations due to their ...
Nare Ko, Jung Won Ahn, Dong Yun Lee, Jin Hwa Chung, Seung Jun Oh, Hyori Kim, Young Pil Kim, Seog-Young Kim, Sang Ju Lee   +8 more
doaj   +2 more sources

Clinical nuclear medicine applications of zirconium-89 immuno-PET: a comprehensive review from a radiopharmaceutical perspective [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Immuno-positron emission tomography (immuno-PET) imaging is emerging as a highly promising technique for the non-invasive diagnosis of a wide range of pathological conditions, particularly in oncology and immunology.
Julien Dubois, Emmanuel Deshayes, Florentin Kucharczak, Marine M. Cadet, Jifang Zhou, Tom Paunet, Cyril Fersing   +6 more
doaj   +2 more sources