Results 1 to 10 of about 14,479 (218)

Noise sensitivity of 89Zr-Immuno-PET radiomics based on count-reduced clinical images [PDF]

EJNMMI Physics, 2022
Purpose Low photon count in 89Zr-Immuno-PET results in images with a low signal-to-noise ratio (SNR). Since PET radiomics are sensitive to noise, this study focuses on the impact of noise on radiomic features from 89Zr-Immuno-PET clinical images.
Ananthi Somasundaram, David Vállez García, Elisabeth Pfaehler, Yvonne W. S. Jauw, Josée M. Zijlstra, Guus A. M. S. van Dongen, Willemien C. Menke-van der Houven van Oordt, Marc C. Huisman, Elisabeth G. E. de Vries, Ronald Boellaard   +9 more
doaj   +5 more sources

Noninvasive Immuno-PET Imaging of CD8+ T Cell Behavior in Influenza A Virus-Infected Mice [PDF]

Frontiers in Immunology, 2021
Immuno-positron emission tomography (immuno-PET) is a noninvasive imaging method that enables tracking of immune cells in living animals. We used a nanobody that recognizes mouse CD8α and labeled it with 89Zr to image mouse CD8+ T cells in the course of ...
Paul W. Rothlauf, Paul W. Rothlauf, Zeyang Li, Novalia Pishesha, Novalia Pishesha, Novalia Pishesha, Novalia Pishesha, Yushu Joy Xie, Andrew W. Woodham, Andrew W. Woodham, Djenet Bousbaine, Stephen C. Kolifrath, Vincent L. Verschoor, Vincent L. Verschoor, Hidde L. Ploegh, Hidde L. Ploegh   +15 more
doaj   +5 more sources

Immuno-PET: Design options and clinical proof-of-concept [PDF]

Frontiers in Medicine, 2022
Radioimmunoconjugates have been used for over 30 years in nuclear medicine applications. In the last few years, advances in cancer biology knowledge have led to the identification of new molecular targets specific to certain patient subgroups. The use of
Alexandre Lugat, Clément Bailly, Clément Bailly, Michel Chérel, Michel Chérel, Caroline Rousseau, Caroline Rousseau, Françoise Kraeber-Bodéré, Françoise Kraeber-Bodéré, Caroline Bodet-Milin, Caroline Bodet-Milin, Mickaël Bourgeois, Mickaël Bourgeois, Mickaël Bourgeois   +13 more
doaj   +2 more sources

Clinical nuclear medicine applications of zirconium-89 immuno-PET: a comprehensive review from a radiopharmaceutical perspective [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Immuno-positron emission tomography (immuno-PET) imaging is emerging as a highly promising technique for the non-invasive diagnosis of a wide range of pathological conditions, particularly in oncology and immunology.
Julien Dubois, Emmanuel Deshayes, Florentin Kucharczak, Marine M. Cadet, Jifang Zhou, Tom Paunet, Cyril Fersing   +6 more
doaj   +2 more sources

Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study [PDF]

BMC Cardiovascular Disorders, 2022
Background In a Phase I study treatment with the serum amyloid P component (SAP) depleter miridesap followed by monoclonal antibody to SAP (dezamizumab) showed removal of amyloid from liver, spleen and kidney in patients with systemic amyloidosis.
Ashutosh Wechalekar, Gunnar Antoni, Wasfi Al Azzam, Mats Bergström, Swethajit Biswas, Chao Chen, Joseph Cheriyan, Matthew Cleveland, Louise Cookson, Paul Galette, Robert L. Janiczek, Raymond Y. Kwong, Mary Ann Lukas, Helen Millns, Duncan Richards, Ian Schneider, Scott D. Solomon, Jens Sörensen, James Storey, Douglas Thompson, Guus van Dongen, Danielle J. Vugts, Anders Wall, Gerhard Wikström, Rodney H. Falk   +24 more
doaj   +7 more sources

Optimal imaging time points considering accuracy and precision of Patlak linearization for 89Zr-immuno-PET: a simulation study [PDF]

EJNMMI Research, 2022
Purpose Zirconium-89-immuno-positron emission tomography (89Zr-immuno-PET) has enabled visualization of zirconium-89 labelled monoclonal antibody (89Zr-mAb) uptake in organs and tumors in vivo.
Jessica E. Wijngaarden, Marc C. Huisman, Johanna E. E. Pouw, C. Willemien Menke-van der Houven van Oordt, Yvonne W. S. Jauw, Ronald Boellaard   +5 more
doaj   +2 more sources

Cysteine-specific 89Zr-labeled anti-CD25 IgG allows immuno-PET imaging of interleukin-2 receptor-α on T cell lymphomas [PDF]

Frontiers in Immunology, 2022
IntroductionPositron emission tomography (PET) using radiolabeled Abs as imaging tracer is called immuno-PET. Immuno-PET can verify therapeutic Ab delivery and can noninvasively quantify global levels of target expression in tumors of living subjects ...
Jin Hee Lee, Jin Hee Lee, Kyung-Ho Jung, Kyung-Ho Jung, Mina Kim, Mina Kim, Kyung-Han Lee, Kyung-Han Lee   +7 more
doaj   +2 more sources

Current and potential roles of immuno-PET/-SPECT in CAR T-cell therapy [PDF]

Frontiers in Medicine, 2023
Chimeric antigen receptor (CAR) T-cell therapies have evolved as breakthrough treatment options for the management of hematological malignancies and are also being developed as therapeutics for solid tumors.
Aditi Mulgaonkar, Durga Udayakumar, Durga Udayakumar, Yaxing Yang, Shelby Harris, Orhan K. Öz, Praveen Ramakrishnan Geethakumari, Xiankai Sun, Xiankai Sun   +8 more
doaj   +2 more sources

How to obtain the image-derived blood concentration from 89Zr-immuno-PET scans [PDF]

EJNMMI Physics
Background PET scans using zirconium-89 labelled monoclonal antibodies (89Zr-mAbs), known as 89Zr-immuno-PET, are made to measure uptake in tumour and organ tissue. Uptake is related to the supply of 89Zr-mAbs in the blood.
Jessica E. Wijngaarden, Amina Ahbari, Johanna E. E. Pouw, Henri N. J. M. Greuter, Idris Bahce, Gerben J. C. Zwezerijnen, Daniëlle J. Vugts, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt, Marc C. Huisman   +10 more
doaj   +2 more sources

A novel diagnosis strategy for chronic inflammatory bowel diseases using immuno-PET of [89Zr]Zr-IL-23p19 antibody [PDF]

Scientific Reports
Inflammatory bowel disease (IBD) is a chronic inflammatory condition requiring accurate and non-invasive imaging for diagnosis and monitoring. Current clinical methods, including Disease Activity Index (DAI) scoring, have limitations due to their ...
Nare Ko, Jung Won Ahn, Dong Yun Lee, Jin Hwa Chung, Seung Jun Oh, Hyori Kim, Young Pil Kim, Seog-Young Kim, Sang Ju Lee   +8 more
doaj   +2 more sources