Results 41 to 50 of about 14,479 (218)

Immuno-PET for Glioma Imaging: An Update

Applied Sciences
Despite significant advances in glioma diagnosis and treatment, overall outcomes remain suboptimal. Exploring novel therapeutic avenues show promise in advancing the field.
Maria Silvia De Feo, Giorgia Maria Granese, Miriam Conte, Barbara Palumbo, Stefano Panareo, Viviana Frantellizzi, Giuseppe De Vincentis, Luca Filippi   +7 more
doaj   +1 more source

Evaluation of 124I-JS001 for hPD1 immuno-PET imaging using sarcoma cell homografts in humanized mice

Acta Pharmaceutica Sinica B, 2020
JS001 (toripalimab) is a humanized IgG monoclonal antibody which strongly inhibits programmed cell death protein 1 (PD1). In this study, we used a different iodine isotype (nat/124/125I) to label JS001 probes to target the human PD1 (hPD1) antigen.
Haifeng Huang, Hua Zhu, Quan Xie, Xiaobin Tian, Xianteng Yang, Fan Feng, Qiyu Jiang, Xinan Sheng, Zhi Yang   +8 more
doaj   +1 more source

Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications. [PDF]

, 2014
Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival.
Bonavida, Benjamin, Shvartsur, Anna
core   +2 more sources

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

-Tyrosine Confers Residualizing Properties to a -Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies

Molecular Imaging, 2016
Purpose: The aims of the study were to develop and evaluate a novel residualizing peptide for labeling internalizing antibodies with 124 I to support clinical development using immuno-positron emission tomography (PET). Methods: The anti-epidermal growth
Fook T. Lee PhD, Ingrid J. G. Burvenich PhD, Nancy Guo MBBS, MSc, Pece Kocovski BSc (Honors), Henri Tochon-Danguy PhD, Uwe Ackermann PhD, Graeme J. O’Keefe PhD, Sylvia Gong PhD, Angela Rigopoulos BSc, MSc, Zhanqi Liu MBBS, PhD, Hui K. Gan MBBS, FRACP, PhD, Andrew M. Scott MBBS, FRACP, MD   +11 more
doaj   +1 more source

Why are we failing to implement imaging studies with radiolabelled new molecular entities in early oncology drug development? [PDF]

, 2014
In early drug development advanced imaging techniques can help with progressing new molecular entities (NME) to subsequent phases of drug development and thus reduce attrition.
Lahn, M, Murphy, P, Plisson, C, Saleem, A   +3 more
core   +3 more sources

Pretargeted PET Imaging with a TCO-Conjugated Anti-CD44v6 Chimeric mAb U36 and [Zr-89]Zr-DFO-PEG(5)-Tz [PDF]

, 2022
The recent advances in the production of engineered antibodies have facilitated the development and application of tailored, target-specific antibodies.
Airaksinen, Anu J., Beaino, Wissam, Chomet, Marion, Hippeläinen, Eero, Imlimthan, Surachet, Lang, Pauline A., Lumen, Dave, Sarparanta, Mirkka, Schreurs, Maxime, Verlaan, Mariska, Vos, Ricardo, Vugts, Danielle, Windhorst, Albert D.   +12 more
core   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Targeting Stereotactic Body Radiotherapy on Metabolic PET- and Immuno-PET-Positive Vertebral Metastases

Biomedicines, 2020
(1) Background: Stereotactic body radiotherapy (SBRT) for vertebral metastases (VM) allows the delivery of high radiation doses to tumors while sparing the spinal cord.
Baptiste Pichon, Caroline Rousseau, Audrey Blanc-Lapierre, Gregory Delpon, Ludovic Ferrer, Vincent Libois, Matthieu Le Turnier, Cédric Lenoble, Caroline Bodet-Milin, David M. Goldenberg, Françoise Kraeber-Bodere, Stéphane Supiot   +11 more
doaj   +1 more source

ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical Neuroscience

Biomolecules, 2023
Immuno-positron emission tomography (immunoPET) is a non-invasive in vivo imaging method based on tracking and quantifying radiolabeled monoclonal antibodies (mAbs) and other related molecules, such as antibody fragments, nanobodies, or affibodies ...
Ángel García de Lucas, Urpo Lamminmäki, Francisco R. López-Picón   +2 more
doaj   +1 more source