Results 21 to 30 of about 14,479 (218)
Diagnostics, 2023 Among humanized monoclonal antibodies, bevacizumab specifically binds to vascular endothelial growth factor A (VEGF-A). VEGF-A is an overexpressed biomarker in cervix carcinoma and is involved in the development and maintenance of tumor-associated neo ...
Csaba Csikos +10 more
doaj +1 more source
Frontiers in Medicine, 2019 Monoclonal antibody (mAb)-based therapies have experienced considerable growth in cancer management. When labeled with radionuclides, mAbs also represent promising probes for imaging or theranostic approaches.
Caroline Bodet-Milin +24 more
doaj +1 more source
First-in-man evaluation of 124I-PGN650: A PET tracer for detecting phosphatidylserine as a biomarker of the solid tumor microenvironment [PDF]
, 2017 Purpose: PGN650 is a F(ab′) 2 antibody fragment that targets phosphatidylserine (PS), a marker normally absent that becomes exposed on tumor cells and tumor vasculature in response to oxidative stress and increases in response to therapy.
Dehdashti, Farrokh +9 more
core +2 more sources
Journal for ImmunoTherapy of Cancer, 2022 Purpose CD103, an integrin specifically expressed on the surface of cancer-reactive T cells, is significantly increased during successful immunotherapy across human malignancies.
Danique Giesen +9 more
doaj +1 more source
Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics [PDF]
, 2015 Antibodies are currently the fastest-growing class of therapeutics. Although naked antibodies have proven valuable as pharmaceutical agents, they have some limitations, such as low tissue penetration and a long circulatory half-life.
Boellaard +14 more
core +1 more source
Radiolabeling human peripheral blood stem cells for positron emission tomography (PET) imaging in young rhesus monkeys. [PDF]
, 2013 These studies focused on a new radiolabeling technique with copper ((64)Cu) and zirconium ((89)Zr) for positron emission tomography (PET) imaging using a CD45 antibody.
Cherry, Simon R +3 more
core +2 more sources
Cerebral rituximab uptake in multiple sclerosis: A (89)Zr-immunoPET pilot study [PDF]
, 2017 Previous studies have demonstrated that the chimeric monoclonal antibody rituximab significantly reduces clinical and radiological disease activity in relapsing-remitting multiple sclerosis as early as 4 weeks after the first administration.
Barkhof, F +6 more
core +1 more source
Quantitative imaging for targeted radionuclide therapy dosimetry : technical review [PDF]
, 2017 Targeted radionuclide therapy (TRT) is a promising technique for cancer therapy. However, in order to deliver the required dose to the tumor, minimize potential toxicity in normal organs, as well as monitor therapeutic effects, it is important to assess ...
Ao, Edwin CI +5 more
core +2 more sources
Molecules, 2021 Immunotherapy is an effective therapeutic option for several cancers. In the last years, the introduction of checkpoint inhibitors (ICIs) has shifted the therapeutic landscape in oncology and improved patient prognosis in a variety of neoplastic diseases.
Virginia Liberini +7 more
doaj +1 more source
Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells [PDF]
, 2018 Immunotherapy using checkpoint-blocking antibodies against targets such as CTLA-4 and PD-1 can cure melanoma and non-small cell lung cancer in a subset of patients. The presence of CD8 T cells in the tumor correlates with improved survival.
Anushka Dongre +55 more
core +1 more source