Results 1 to 10 of about 8,420 (193)

A generic 89Zr labeling method to quantify the in vivo pharmacokinetics of liposomal nanoparticles with positron emission tomography [PDF]

International Journal of Nanomedicine, 2017
Nan Li,1,2,* Zilin Yu,1,* Truc Thuy Pham,1,* Philip J Blower,1 Ran Yan1 1Division of Imaging Sciences and Biomedical Engineering, St Thomas’ Hospital, King’s College London, London, UK; 2Tianjin Key Laboratory for Modern Drug Delivery & ...
Li N, Yu Z, Pham TT, Blower PJ, Yan R
doaj   +3 more sources

A novel diagnosis strategy for chronic inflammatory bowel diseases using immuno-PET of [89Zr]Zr-IL-23p19 antibody [PDF]

Scientific Reports
Inflammatory bowel disease (IBD) is a chronic inflammatory condition requiring accurate and non-invasive imaging for diagnosis and monitoring. Current clinical methods, including Disease Activity Index (DAI) scoring, have limitations due to their ...
Nare Ko, Jung Won Ahn, Dong Yun Lee, Jin Hwa Chung, Seung Jun Oh, Hyori Kim, Young Pil Kim, Seog-Young Kim, Sang Ju Lee   +8 more
doaj   +2 more sources

Evaluation of [89Zr]Zr-girentuximab PET imaging of clear cell renal cell carcinoma in Chinese patients: a Phase 1 clinical study (ZIRDOSE-CP) [PDF]

EJNMMI Research
Background Results from a multinational Phase 3 study demonstrated high accuracy and a favorable safety and tolerability profile of [89Zr]Zr-girentuximab PET for detection and characterization of clear cell renal cell carcinoma (ccRCC). However, [89Zr]Zr-
Chen Liu, Yongpeng Ji, Xiaoyan Wu, Brenda Cerqueira, David Cade, Peng Du, Zhi Yang   +6 more
doaj   +2 more sources

89Zr-mAb uptake interpretation requires the use of tissue to plasma ratios corrected for antibody catabolism [PDF]

EJNMMI Research
Background Typically, tissue uptake, expressed in tissue over plasma ratio (TPR), is reported from a 89Zr-mAb PET study. Nonspecific antibody catabolism and the residualizing property of 89Zr hamper the use of tissue uptake as a measure for target ...
Marc C. Huisman, Johanna E. E. Pouw, Sandeep S. V. Golla, Damien Huglo, Franck Morschhauser, Josée M. Zijlstra, Jessica E. Wijngaarden, Mirte Stavenga, Hylke J. Sebus, Maarten Slebe, Andrea Thiele, Danielle Vugts, Iris H. C. Miedema, Gerben J.C. Zwezerijnen, Idris Bahce, C. Willemien Menke-van der Houven van Oordt, Dhaval K. Shah, Yvonne W. S. Jauw, Ronald Boellaard   +18 more
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Development and evaluation of 89Zr-trastuzumab for clinical applications [PDF]

Asia Oceania Journal of Nuclear Medicine and Biology, 2023
Objective(s): Due to the suitable physical characteristics of 89Zr as a PET radionuclide and affinity of Trastuzumab monoclonal antibody against HER2, [89Zr]Zr-Trastuzumab was prepared and went through preclinical evaluations for ultimate human ...
Fatemeh Mohammadpour-Ghazi, Hassan Yousefnia, GhasemAli Divband, Samaneh Zolghadri, Behrouz Alirezapour, Fatemeh Shakeri   +5 more
doaj   +1 more source

Evaluation of different 89Zr-labeled synthons for direct labeling and tracking of white blood cells and stem cells in healthy athymic mice

Scientific Reports, 2022
Cell based therapies are evolving as an effective new approach to treat various diseases. To understand the safety, efficacy, and mechanism of action of cell-based therapies, it is imperative to follow their biodistribution noninvasively.
Aditya Bansal, Shalini Sharma, Benedikt Klasen, Frank Rösch, Mukesh K. Pandey   +4 more
doaj   +1 more source

Comparative in vivo biodistribution of cells labelled with [89Zr]Zr-(oxinate)4 or [89Zr]Zr-DFO-NCS using PET

EJNMMI Research, 2023
Background In vivo monitoring of cell biodistribution using positron emission tomography (PET) provides a quantitative non-invasive method to further optimize cell therapies and related new developments in the field.
Ida Friberger, Joachim N. Nilsson, Li Lu, Jonathan Siikanen, Oscar Ardenfors, Stefan Milton, Erik Samén, Jeroen A. C. M. Goos, Mattias Carlsten, Staffan Holmin, Thuy A. Tran   +10 more
doaj   +1 more source

Automated light-induced synthesis of 89Zr-radiolabeled antibodies for immuno-positron emission tomography

Scientific Reports, 2022
Clinical production of 89Zr-radiolabeled antibodies (89Zr-mAbs) for positron emission tomography imaging relies on the pre-conjugation of desferrioxamine B (DFO) to the purified protein, followed by isolation and characterization of the functionalized ...
Simon Klingler, Jason P. Holland
doaj   +1 more source

Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery [PDF]

, 2020
Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD).
Huang, Hui, Huang, Jiansheng, Huang, Li-Hao, Wang, Dongdong   +3 more
core   +2 more sources

89Zr-PET imaging to predict tumor uptake of 177Lu-NNV003 anti-CD37 radioimmunotherapy in mouse models of B cell lymphoma

Scientific Reports, 2022
[177Lu]Lu-DOTA-NNV003, a radioimmunoconjugate targeting CD37, is developed as novel radioimmunotherapy (RIT) treatment for patients with B cell non-Hodgkin’s lymphoma (NHL).
Danique Giesen, Marjolijn N. Lub-de Hooge, Marcel Nijland, Helen Heyerdahl, Jostein Dahle, Elisabeth G. E. de Vries, Martin Pool   +6 more
doaj   +1 more source