Results 11 to 20 of about 8,420 (193)

Automated synthesis of [89Zr]ZrCl4, [89Zr]ZrDFOSquaramide-bisPh(PSMA) and [89Zr]ZrDFOSquaramide-TATE

EJNMMI Radiopharmacy and Chemistry
Background Automated [89Zr]Zr-radiolabeling processes have the potential to streamline the production of [89Zr]Zr-labelled PET imaging agents. Most radiolabeling protocols use [89Zr][Zr(ox)4]4− as the starting material and oxalate is removed after ...
Asif Noor, Peter D. Roselt, Emily R. McGowan, Stan Poniger, Michael P. Wheatcroft, Paul S. Donnelly   +5 more
doaj   +4 more sources

Development of 89Zr Labelled Radiopharmaceuticals

Journal of Isotopes, 2016
Positron emission tomography (PET) is the most advanced molecular imaging technology with the advantage of high sensitivity and quantity analysis. Molecule probe is the key factor for PET.
WANG Li-zhen;YANG Min
doaj   +2 more sources

Routine Production of 89Zr Using an Automated Module [PDF]

Applied Sciences, 2013
89Zr has emerged as a useful radioisotope for targeted molecular imaging via positron emission tomography (PET) in both animal models and humans. This isotope is particularly attractive for cancer research because its half-life (t1/2 = 3.27 days) is well-
Benjamin C. Lewis, Suzanne E. Lapi, Efrem Mebrahtu, Gordon D. Schweitzer, A. Lake Wooten, Luke A. Lawrence, Evelyn Madrid   +6 more
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Annotating MYC status with 89Zr-transferrin imaging [PDF]

Nature Medicine, 2012
A noninvasive technology that quantitatively measures the activity of oncogenic signaling pathways could have a broad impact on cancer diagnosis and treatment with targeted therapies. Here we describe the development of (89)Zr-desferrioxamine-labeled transferrin ((89)Zr-transferrin), a new positron emission tomography (PET) radiotracer that binds the ...
Jason P, Holland, Michael J, Evans, Samuel L, Rice, John, Wongvipat, Charles L, Sawyers, Jason S, Lewis   +5 more
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89Zr Radiochemistry for Positron Emission Tomography [PDF]

Medicinal Chemistry, 2011
The positron emitting isotope (89)Zr is an ideal radionuclide for use in positron emission tomography (PET) imaging with monoclonal antibodies (mAbs). This article reviews the cyclotron physics of (89)Zr production, and the chemical separation methods for isolating it from yttrium target material.
Gregory W, Severin, Jonathan W, Engle, Todd E, Barnhart, R Jerry, Nickles   +3 more
openaire   +2 more sources

Preclinical PET imaging with the novel human antibody 89Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues

Journal for ImmunoTherapy of Cancer, 2021
Background Programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) blocking antibodies including cemiplimab have generated profound clinical activity across diverse cancer types.
Gavin Thurston, Richard Tavare, Marcus P Kelly, Sosina Makonnen, Carlos Hickey, T Cody Arnold, Jason T Giurleo, Makenzie Danton, Christian Granados, Ishita Chatterjee, Drew Dudgeon, Marc W Retter, Dangshe Ma, William C Olson, Jessica R Kirshner   +14 more
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Level structure of 89Zr via the reaction 90Zr(p, d)89Zr

Physics Letters B, 1968
Abstract Levels in 89Zr up to about 13 MeV have been excited via the reaction 90Zr(p,d)89Zr. The over-all level structure obtained is qualititively consistent with the concept that most of the levels are due to 9 2 , 2 p 1 2 , 2 p 3 2 , 1 f 5 2 , and possibly 1 7 2 neutron hole states fragmented by isospin ...
H. Taketani, M. Adachi, Y. Yoshida, M. Ogawa, K. Ashibe   +4 more
openaire   +2 more sources

Preclinical PET imaging of bispecific antibody ERY974 targeting CD3 and glypican 3 reveals that tumor uptake correlates to T cell infiltrate

Journal for ImmunoTherapy of Cancer, 2020
Background Bispecific antibodies redirecting T cells to the tumor obtain increasing interest as potential cancer immunotherapy. ERY974, a full-length bispecific antibody targeting CD3ε on T cells and glypican 3 (GPC3) on tumors, has been in clinical ...
Stijn JH Waaijer, Danique Giesen, Takahiro Ishiguro, Yuji Sano, Naofumi Sugaya, Carolina P Schröder, Elisabeth GE de Vries, Marjolijn N Lub-de Hooge   +7 more
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A peristaltic pump driven 89Zr separation module [PDF]

, 2012
To facilitate the separation of 89Zr produced in yttrium foils, an automated separation module was designed and assembled. The module separates more than 85% of produced 89Zr - activity in 3 g foils in less than 90 min. About 10 % remains in the dissolving vial.
Ohlsson, T., Peterson, M., Roos, Per, Sandell, A., Siikanen, J., Tran, T.   +5 more
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Performance of 89Zr-Labeled-Rituximab-PET as an Imaging Biomarker to Assess CD20 Targeting: A Pilot Study in Patients with Relapsed/Refractory Diffuse Large B Cell Lymphoma. [PDF]

PLoS ONE, 2017
Treatment of patients with diffuse large B cell lymphoma (DLBCL) includes rituximab, an anti-CD20 monoclonal antibody (mAb). Insufficient tumor targeting might cause therapy failure. Tumor uptake of 89Zirconium (89Zr)-mAb is a potential imaging biomarker
Yvonne W S Jauw, Josée M Zijlstra, Daphne de Jong, Danielle J Vugts, Sonja Zweegman, Otto S Hoekstra, Guus A M S van Dongen, Marc C Huisman   +7 more
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