Immuno-positron emission tomography with zirconium-89-labeled monoclonal antibodies in oncology
Frontiers in Pharmacology, 2016 Selection of the right drug for the right patient is a promising approach to increase clinical benefit of targeted therapy with monoclonal antibodies (mAbs).
Yvonne W.S. Jauw +7 more
doaj +1 more source
Cerebral rituximab uptake in multiple sclerosis: A (89)Zr-immunoPET pilot study [PDF]
, 2017 Previous studies have demonstrated that the chimeric monoclonal antibody rituximab significantly reduces clinical and radiological disease activity in relapsing-remitting multiple sclerosis as early as 4 weeks after the first administration.
Barkhof, F +6 more
core +1 more source
Performance of 89Zr-Labeled-Rituximab-PET as an Imaging Biomarker to Assess CD20 Targeting: A Pilot Study in Patients with Relapsed/Refractory Diffuse Large B Cell Lymphoma. [PDF]
PLoS ONE, 2017 Treatment of patients with diffuse large B cell lymphoma (DLBCL) includes rituximab, an anti-CD20 monoclonal antibody (mAb). Insufficient tumor targeting might cause therapy failure. Tumor uptake of 89Zirconium (89Zr)-mAb is a potential imaging biomarker
Yvonne W S Jauw +7 more
doaj +1 more source
Targeting of radiolabeled J591 antibody to PSMA-expressing tumors: optimization of imaging and therapy based on non-linear compartmental modeling [PDF]
, 2016 BACKGROUND: We applied a non-linear immunokinetic model to quantitatively compare absolute antibody uptake and turnover in subcutaneous LNCaP human prostate cancer (PCa) xenografts of two radiolabeled forms of the humanized anti-prostate-specific ...
Blesida Punzalan +13 more
core +1 more source
Pretargeted PET Imaging with a TCO-Conjugated Anti-CD44v6 Chimeric mAb U36 and [Zr-89]Zr-DFO-PEG(5)-Tz [PDF]
, 2022 The recent advances in the production of engineered antibodies have facilitated the development and application of tailored, target-specific antibodies.
Airaksinen, Anu J. +12 more
core +1 more source
Nanobody constructs, targeting growth factors and their receptors, for PET imaging and cancer therapy [PDF]
, 2012 Dongen, G.A.M.S. van [Promotor]Visser, G.W.M. [Copromotor]Bergen en Henegouwen, P.M.P.
Vosjan, M.J.W.D.
core +13 more sources
89Zr-Radiolabeled Trastuzumab Imaging in Orthotopic and Metastatic Breast Tumors [PDF]
, 2012 The human epidermal growth factor receptor 2 (HER2/neu) is overexpressed in 20-30% of breast cancers and is associated with tumor growth, angiogenesis, and development of distant metastases.
Chang, Albert J. +5 more
core +3 more sources
Scientific Reports, 2021 CD44 is a cell-surface glycoprotein involved in cell–cell interaction, adhesion, and migration. CD44 is found on colon cancer cells and on immune cells.
Jin Won Park +5 more
doaj +1 more source
Noninvasive Immuno-PET Imaging of CD8+ T Cell Behavior in Influenza A Virus-Infected Mice
Frontiers in Immunology, 2021 Immuno-positron emission tomography (immuno-PET) is a noninvasive imaging method that enables tracking of immune cells in living animals. We used a nanobody that recognizes mouse CD8α and labeled it with 89Zr to image mouse CD8+ T cells in the course of ...
Paul W. Rothlauf +15 more
doaj +1 more source
Non invasive imaging assessment of the biodistribution of GSK2849330, an ADCC and CDC optimized anti HER3 mAb, and its role in tumor macrophage recruitment in human tumor-bearing mice. [PDF]
PLoS ONE, 2017 The purpose of this work was to use various molecular imaging techniques to non-invasively assess GSK2849330 (anti HER3 ADCC and CDC enhanced 'AccretaMab' monoclonal antibody) pharmacokinetics and pharmacodynamics in human xenograft tumor-bearing mice ...
Hasan Alsaid +12 more
doaj +1 more source