Results 91 to 100 of about 8,420 (193)

Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein 27 (TMEM27) [PDF]

, 2018
Aims/hypothesis: Non-invasive diagnostic tools specific for pancreatic beta cells will have a profound impact on our understanding of the pathophysiology of metabolic diseases such as diabetes.
Danzer, C., Dikaiou, K., Esterhazy, D., Fischer, E., Honer, M., Keist, R., Krek, W., Matile, H., Migliorini, C., Ripoll, J., Rudin, M., Schibli, R., Stoffel, M., Stuker, F., Vats, D., Wang, H.   +15 more
core  

Leveraging PET to image folate receptor α therapy of an antibody-drug conjugate

EJNMMI Research, 2018
Background The folate receptor α (FRα)-targeting antibody-drug conjugate (ADC), IMGN853, shows great antitumor activity against FRα-expressing tumors in vivo, but patient selection and consequently therapy outcome are based on immunohistochemistry.
Christian Brand, Ahmad Sadique, Jacob L. Houghton, Kishore Gangangari, Jose F. Ponte, Jason S. Lewis, Naga Vara Kishore Pillarsetty, Jason A. Konner, Thomas Reiner   +8 more
doaj   +1 more source

Electric quadrupole and magnetic dipole moments of odd nuclei near the magic ones in a self-consistent approach

, 2015
We present a model which describes the properties of odd-even nuclei with one nucleon more, or less, with respect to the magic number. In addition to the effects related to the unpaired nucleon, we consider those produced by the excitation of the closed ...
Anguiano, M., Bernard, R. N., Co', G., De Donno, V., Lallena, A. M.   +4 more
core   +1 more source

Preclinical evaluation and automated synthesis of [89Zr]ZrDFOSquaramide-girentuximab for diagnostic imaging of carbonic anhydrase IX positive tumours

EJNMMI Radiopharmacy and Chemistry
Background Carbonic Anhydrase IX (CAIX) is a zinc metalloenzyme that is over-expressed in many cancers making it a valid target for targeted diagnostic imaging with Positron Emission Tomography (PET).
Asif Noor, Emily R. McGowan, Jessica K. Van Zuylekom, Carleen Cullinane, Peter D. Roselt, Rodney J. Hicks, Michael P. Wheatcroft, Paul S. Donnelly   +7 more
doaj   +1 more source

ImmunoPET imaging of TIGIT in the glioma microenvironment

Scientific Reports
Glioblastoma (GBM) is the most common primary malignant brain tumor. Currently, there are few effective treatment options for GBM beyond surgery and chemo-radiation, and even with these interventions, median patient survival remains poor.
Sarah R. Vincze, Ambika P. Jaswal, Stephen C. Frederico, Michal Nisnboym, Bo Li, Zujian Xiong, ReidAnn E. Sever, Chaim T. Sneiderman, Mikayla Rodgers, Kathryn E. Day, Joseph D. Latoche, Lesley M. Foley, T. Kevin Hitchens, Robin Frederick, Ravi B. Patel, Costas G. Hadjipanayis, Itay Raphael, Jessie R. Nedrow, W. Barry Edwards, Gary Kohanbash   +19 more
doaj   +1 more source

Human Absorbed Dose Estimation of 89Zr-Anti-HER2 Complex Based on Animal Data [PDF]

Iranian Journal of Medical Physics
Introduction: This study aimed to estimate the radiation absorbed dose of human organs after injection of a high-potential PET radioimmunoconjugate of HER2+ breast cancers using the medical internal radiation dose (MIRD) method and the radiation dose ...
Hassan Yousefnia, samaneh zolghadri, Arezou Karimian   +2 more
doaj   +1 more source

Synthesis and preclinical evaluation of a 89Zr-labelled human single chain antibody for non-invasive detection of hepatic myofibroblasts in acute liver injury

Scientific Reports
Synaptophysin is expressed on fibrogenic hepatic myofibroblasts. C1–3 is a single chain human antibody (scAb) that binds specifically to synaptophysin on hepatic myofibroblasts, providing a targeting vector for novel in vivo imaging agents of chronic ...
Toni A. Pringle, Erik Ramon-Gil, Jack Leslie, Fiona Oakley, Matthew C. Wright, James C. Knight, Saimir Luli   +6 more
doaj   +1 more source

Properties of Zirconia Nanoceramics under High-Energy Electrons Irradiation [PDF]

, 2013
Formation of radioactive isotopes is investigated under irradiation by relativistic electrons with energy up to 100 MeV. Radioactive isotopes 87,88Y, 88,89,95Zr, 95Nb, 175Hf are registered after irradiation by relativistic electrons with energy 47.2 ...
Aizatsky, N.I., Danilenko, I.A., Dikiy, N.P., Dovbnya, A.N., Fedorets, I.D., Konstantinova, T.E., Kushnir, V.A., Lyashko, Yu.V., Medvedev, D.V., Mytrochenko, V.V., Onishchenko, I.N., Perezhogin, S.A.   +11 more
core  

A radioactive CRISPR interference system using 89Zr-labeled LbCas12a

Journal of Controlled Release
Recently, CRISPR proteins have been recognized as promising candidates for drug development. However, there is still a lack of substances with the appropriate sensitivity and stability for targeted drug delivery systems. 89Zr is a radioactive isotope that emits positrons, allowing real-time in vivo tracking with proven safety.
Injoo, Hwang, Jun Young, Lee, Tae-Hyun, Kim, Eun Ju, Lee, Jeeho, Kim, Hyomin, Park, Min Goo, Hur, Sanghwa, Lee, Jeong-Hoon, Park   +8 more
openaire   +2 more sources

Biodistribution and persistence of human umbilical cord-derived mesenchymal stem cells in NCG mice: a comparative study

Future Science OA
Introduction This study aims to investigate the biodistribution and persistence of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) in NCG mice post-intravenous injection, utilizing 89Zr-PET/CT, bioluminescence imaging, multiplex ...
Guangyang Liu, Herui Wang, Xin Li, Yi Mi, Chenliang Zhang, Yaoyao Chen, Li Miao, Haomiao Long, Jun He, Qinggang Ge, Yongjun Liu   +10 more
doaj   +1 more source