Results 61 to 70 of about 8,420 (193)

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source

First-in-human infection imaging with 89Zr-labelled leukocytes and comparison of scan quality with [99mTc]Tc-HMPAO-labelled leukocytes

Frontiers in Nuclear Medicine
IntroductionNuclear medicine infection imaging is routinely performed with the use of leukocytes radiolabelled with technetium-99m hexamethylpropyleneamine oxime ([99mTc]Tc-HMPAO) and single-photon emission computed tomography (SPECT).
Maryke Kahts, Beverley Summers, Akhona Nkokheli Ndlela, Aadil Gutta, Aadil Gutta, Phumudzo Nemutaduni, Andrew More, Aman Parsoo, Thomas Ebenhan, Thomas Ebenhan, Jan Rijn Zeevaart, Jan Rijn Zeevaart, Jan Rijn Zeevaart, Omer Aras, Omer Aras, Mike Machaba Sathekge   +15 more
doaj   +1 more source

89Zr-pembrolizumab biodistribution is influenced by PD-1-mediated uptake in lymphoid organs

Journal for ImmunoTherapy of Cancer, 2020
Background To better predict response to immune checkpoint therapy and toxicity in healthy tissues, insight in the in vivo behavior of immune checkpoint targeting monoclonal antibodies is essential.
Annelies Jorritsma-Smit, Elisabeth G E de Vries, Danique Giesen, Marjolijn N Lub-de Hooge, Elly L van der Veen, Linda Pot-de Jong   +5 more
doaj   +1 more source

A novel method to quantify IRDye800CW fluorescent antibody probes ex vivo in tissue distribution studies [PDF]

, 2012
BACKGROUND: We describe a new method for biodistribution studies with IRDye800CW fluorescent antibody probes. This method allows the quantification of the IRDye800CW fluorescent tracer in percentage of injected dose per gram of tissue (% ID/g), and it is
Bergen en Henegouwen, P.M. van, Cohen, R., Diest, P.J. van, Dongen, G.A.M.S. van, Elias, S.G., Mali, W., Oliveira, S., Walsum, M.S.   +7 more
core   +1 more source

Preparation of 89Zr by Cyclotron and its Purification and Labeling Methods

Journal of Isotopes
In order to obtain high quality 89Zr nuclide for nuclear medicine imaging, 89Zr was produced by irradiating 89Y with HM-20S cyclotron. The nuclear reaction excitation function was calculated.
XU Zhiyu1, 2, YANG Dacan3, WANG Guixiang1, 2, CHENG Wanting3, WANG Fengqing3, MA Fuqiu1, 2
doaj   +1 more source

Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis [PDF]

, 2014
The need for post-synthetic modifications and reactive prosthetic groups has long been a limiting factor in the synthesis and study of peptidic and peptidomimetic imaging agents.
Emmetiere, Fabien, Lewis, Jason S, Pillarsetty, Nagavarakishore, Reiner, Thomas, Weissleder, Ralph, Zeglis, Brian M   +5 more
core   +1 more source

Oligoprogressive renal cell carcinoma: What is the role of surgery?

BJU International, EarlyView.
Objective To provide an overview of the biological mechanism and pattern of oligoprogression in renal cell carcinoma (RCC) and the most updated role of surgery in this setting, highlighting scientific gaps and informing future implications. Methods A non‐systematic search of PubMed/MEDLINE was performed in August 2025 including guidelines, reviews, and
Chiara Re, William H.J. Ince, Leo Bickley, James P. Blackmur, Mouhamad H. Ismail, Justicia Kyeremeh, Teele Kuusk, Eva Mendes Serrao, James O. Jones, Grant D. Stewart   +9 more
wiley   +1 more source

Good practices for 89Zr radiopharmaceutical production and quality control

EJNMMI Radiopharmacy and Chemistry
Background During the previous two decades, PET imaging of biopharmaceuticals radiolabeled with zirconium-89 has become a consistent tool in preclinical and clinical drug development and patient selection, primarily due to its advantageous physical ...
Thomas Erik Wuensche, Serge Lyashchenko, Guus A. M. S. van Dongen, Danielle Vugts   +3 more
doaj   +1 more source

Production Process of 89Zr Based on C30 Cyclotron

Yuanzineng kexue jishu
Due to the good decay modes and suitable half-life, 89Zr is widely used in the field of immune-PET imaging. The objective is to develop a new target system suitable for cyclotron nuclide production and to obtain a new method for batch production of 89Zr.
WEN Kai1,2,3,  DUAN Fei1,2,3,  LI Guang1,2,3,  MA Chengwei1,2,3,  WANG Xiaoming1,2,3,  ZHAO Ziyu1,2,3,  CHU Haomiao1,2,3,  LI Chao1,2,3,  WANG Chengzhi1,2,3,  WANG Chunlin1,2,3
doaj   +1 more source

Comparative Study with 89Y-foil and 89Y-pressed Targets for the Production of 89Zr †

Applied Sciences, 2018
Zirconium-89 (89Zr, t1/2 = 3.27 days) owns great potential in nuclear medicine, being extensively used in the labelling of antibodies and nanoparticules. 89Zr can be produced by cyclotron via an 89Y(p,n)89Zr reaction while using an 89Y-foil target.
Aiman H. Alnahwi, Sébastien Tremblay, Brigitte Guérin   +2 more
doaj   +1 more source