Results 51 to 60 of about 82,073 (245)

Linear Multiselenium Interactions in Dicationic Oligomers of 1,5‐(Diselena)canes: Behavior of Semc σ(mcc‐nee) (6≤mc≤16) Elucidated with QTAIM Dual Functional Analysis

ChemistryOpen, 2021
Invited for this month's cover picture is the group of Dr. Satoko Hayashi at Faculty of Systems Engineering and Chemistry at Wakayama University. The cover picture shows the linear Se16 σ(16c–30e) interactions, illustrated by the molecular graph type on ...
Dr. Satoko Hayashi, Taro Nishide, Kengo Nagata, Prof. Waro Nakanishi   +3 more
doaj   +1 more source

Lewis Pair‐Engineered CuMnOx as Cold‐Adapted Multinanozyme for Cooperative Hydrolytic and Oxidative Degradation of Raw Corn Stalk

Advanced Science, EarlyView.
A Lewis pair site design strategy was established to construct Cu‐doped Mn‐based amorphous nanozymes, where Mn and oxygen vacancies generate cooperative acid‐base pairs. The resulting multinanozyme integrates glycosidase‐, oxidase‐, and cold‐adapted enzyme‐mimicking activities, enabling cooperative depolymerization of cellulose and hemicellulose ...
Huile Liu, Ziyi Di, Qing Tian, Yue Zhou, Rong Yang, Zhiyi Bai, Haoyu Wang, Yao Chen, Lianbing Zhang   +8 more
wiley   +1 more source

Climate Action Impacts on Steelmaking Emissions of Persistent Organic Pollutants Highlight a Gap Between the Paris Agreement and the Stockholm Convention

Advanced Science, EarlyView.
Emissions of unintentionally produced persistent organic pollutants (UPOPs) and global warming are two major environmental challenges. But their governance has largely evolved in parallel, leaving the toxicity implications of climate‐driven industrial transitions poorly understood.
Yuxiang Sun, Qiuting Yang, Jianghui Yun, Yujue Yang, Junhao Tang, Qian Liu, Minghui Zheng, Guorui Liu   +7 more
wiley   +1 more source

Interplay of Oxidative Stress, Autophagy, and Rubicon in Ovarian Follicle Dynamics: Orchestrating Ovarian Aging

Antioxidants
Organ functions generally decline with age, but the ovary is a prototypical organ that undergoes functional loss over time. Autophagy plays a crucial role in maintaining organ homeostasis, and age-related upregulation of the autophagy inhibitor protein ...
Kiyotaka Yamada, Masami Ito, Haruka Nunomura, Takashi Nishigori, Atsushi Furuta, Mihoko Yoshida, Akemi Yamaki, Kanto Shozu, Ippei Yasuda, Sayaka Tsuda, Tomoko Shima, Akitoshi Nakashima   +11 more
doaj   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Revised Two-Stage Model of Preeclampsia Based on Autophagic Dysfunction: A Comprehensive Review

Biomolecules
A revised two-stage model of preeclampsia is proposed, centering on an autophagy-dependent requirement for extravillous trophoblast entry into the proximal one-third of the myometrium.
Atsushi Furuta, Tomoko Shima, Takashi Nishigori, Kiyotaka Yamada, Haruka Nunomura, Mihoko Yoshida, Shina Sakaguchi, Takuya Majima, Akemi Yamaki-Ushijima, Kanto Shozu, Sayaka Tsuda, Shibin Cheng, Surendra Sharma, Akitoshi Nakashima   +13 more
doaj   +1 more source

Chotosan, a Kampo Formula, Ameliorates Chronic Cerebral Hypoperfusion-Induced Deficits in Object Recognition Behaviors and Central Cholinergic Systems in Mice

Journal of Pharmacological Sciences, 2007
We previously demonstrated that the Kampo formula chotosan (CTS) ameliorated spatial cognitive impairment via central cholinergic systems in a chronic cerebral hypoperfusion (P2VO) mouse model.
Qi Zhao, Yukihisa Murakami, Michihisa Tohda, Ryosuke Obi, Yutaka Shimada, Kinzo Matsumoto   +5 more
doaj   +1 more source

Annual Report of the 2022 National Clinical Database: Decade‐Long Trends and Current Status of Gastroenterological Surgery in Japan

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim The National Clinical Database (NCD) of Japan is the largest nationwide registry, covering over 95% of surgeries in the country. This 2022 annual report summarizes the short‐term outcomes of gastroenterological surgeries and discusses trends and insights over the past decade.
Koshi Kumagai, Arata Takahashi, Hideki Ueno, Naoki Hiki, Yoshiki Kajiwara, Tomoki Ebata, Takao Otsuka, Taro Oshikiri, Yoshihiro Kakeji, Takanori Goi, Akio Saiura, Hiroshi Saeki, Chie Tanaka, Masanori Tokunaga, Tsutomu Fujii, Satoru Matsuda, Tsunekazu Mizushima, Hiroyuki Yamamoto, Yuko Kitagawa, Ken Shirabe   +19 more
wiley   +1 more source

Diabetes-Induced Central Cholinergic Neuronal Loss and Cognitive Deficit Are Attenuated by Tacrine and a Chinese Herbal Prescription, Kangen-Karyu: Elucidation in Type 2 Diabetes db/db Mice

Journal of Pharmacological Sciences, 2011
.: We investigated the effect of kangen-karyu (KK), a Chinese herbal prescription, on cognitive deficits and central cholinergic systems of type 2 diabetic db/db mice. Seven-week-old db/db (Y-db/db) mice received daily administration of test drugs during
Qi Zhao, Kinzo Matsumoto, Koichi Tsuneyama, Ken Tanaka, Feng Li, Naotoshi Shibahara, Takeshi Miyata, Takako Yokozawa   +7 more
doaj   +1 more source

Primary Tumor Resection in Patients With Unresectable Metastatic Colorectal Cancer: A Systematic Review and Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
This systematic review and meta‐analysis evaluated the role of primary tumor resection (PTR) in asymptomatic patients with unresectable metastatic colorectal cancer. Across 17 eligible studies including 9317 patients, PTR did not improve overall or progression‐free survival compared with chemotherapy alone.
Junpei Takashima, Hirotoshi Kobayashi, Daisuke Fujimoto, Fumihiko Miura   +3 more
wiley   +1 more source